Chimeras have been an important part of animal research for decades. Yet crossing the species barrier has always been seen as potentially morally problematic. In recent years, advances in chimeric research and the attendant possibilities—organ xenotransplantation, cognitive enhancement, and others—have given rise to further ethical concern. This contribution surveys the main ethical questions that

Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform co

Three-dimensional numerical simulations are successfully carried out on thermo-hydraulic characteristics of a new plain fin-and-elliptical tube (PFET) heat exchanger with innovative types of tube-banks, namely—a slotted elliptical tube-bank (SETB) (Case B and Case C) and a slotted annular elliptical tube-bank (SAETB) (Case D and Case E). The new PFET heat exchanger contains elliptical cross-sectio

Purpose: Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the poor prognosis of high-grade glioma patients, and is known to contribute to the development of treatment resistance. Therefore, new strategies to comprehensively profile and monitor the hypoxic status of gliomas are of high clinical relevanc

Recent research showed that exposure to the vaccine against polio in early life had no long-term economic benefits among native Swedes. However, whether this result holds for individuals from other countries remains unexplored. This study explores the relationship between exposure to the vaccine and later-life outcomes, but focuses on individuals who migrated to Sweden (birth cohorts 1946-1971), w

The synthesis of core@shell nanoparticles has predominantly been carried out by chemical methods or physical deposition of a shell material post-growth onto core particles. By combining immiscible materials that differ in surface energy, we demonstrate the spontaneous atomic rearrangement to monodisperse Cu@Ag core@shell particles directly in the aerosol phase, starting from pure Cu and Ag electro

It is not physically obvious why one can calculate with similar accuracy, as compared to the experimental data, the absolute cross section associated with two-nucleon transfer processes between members of pairing rotational bands, making use of simple BCS (constant matrix elements) or of many-body [Nambu-Gorkov (NG), nuclear field theory (NFT)] spectroscopic amplitudes. Restoration of spontaneous

Cajal-Retzius (CR) cells of the cerebral cortex express receptors for the neurotrophin brain-derived neurotrophic factor (BDNF) and downregulate expression of the extracellular matrix protein Reelin during early postnatal development, coincident with the onset of cortical BDNF expression. During this period, mice lacking BDNF have elevated levels of Reelin in CR cells. Acute BDNF stimulation of co

The aim of this article is to determine how human interventions in upstream countries coupled with drought events are affecting the flow regime of downstream countries using the Nile River basin for illustrative purposes. This has been addressed by assessing climate change in the study area through analyses of precipitation data obtained from the Global Precipitation Climatology Centre (GPCC) and

AIMS: The main aim of this study was to assess dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and airway exposure to PAHs, volatile organic compounds (VOCs; benzene and 1,3-butadiene), and particles among firefighters (FFs) and police forensic investigators (PFIs) in Sweden. METHODS: Active (pump with a filter and sorbent tube) and passive (polyurethane foam -cyl and perkin elmer carbo

Coaxial quantum wells (QWs) are ideal candidates for nanowire (NW) lasers, providing strong carrier confinement and allowing close matching of the cavity mode and gain medium. We report a detailed structural and optical study and the observation of lasing for a mixed group-V GaAsP NW with GaAs QWs. This system offers a number of potential advantages in comparison to previously studied common group

Background: Positive psychology indicators like well-being and life satisfaction may play a pivotal role in pain-related outcomes. In this study, we aimed to examine the prospective associations of positive well-being and life satisfaction with pain severity. Methods and Subjects: This longitudinal study, with a follow-up of 2 years, included 9361 participants (4266 males, 5095 females; mean age:

Objective: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash Associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. Methods: A three-step process was used. 1