Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and chronic traumatic encephalopathy. A growing body of literature suggests that conformational characteristics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct histopathological morpho

Soil contamination is a widespread problem and action needs to be taken in order to prevent damage to the groundwater and the life around the contaminated sites. In Sweden, it is estimated that more than 80,000 sites are potentially contaminated, and therefore, there is a demand for investigations and further treatment of the soil. In this paper, we present the results from a methodology applied i

Global greenhouse gas emissions from air travel (GHG-A) are on the rise, and projections point towards a rapid growth in the coming decades. This study aims to examine how local government (cities), addresses GHG-A in their Sustainable Energy Action Plans (SEAP). To fulfil this aim, over 200 SEAPs were analysed focusing on three issues: (1) Treatment of GHG-A in local emissions inventories; (2) PoGlobal greenhouse gas emissions from air travel (GHG-A) are on the rise, and projections point towards a rapid growth in the coming decades. This study aims to examine how local government (cities), addresses GHG-A in their Sustainable Energy Action Plans (SEAP). To fulfil this aim, over 200 SEAPs were analysed focusing on three issues: (1) Treatment of GHG-A in local emissions inventories; (2) Po

Avhandlingsarbetet studerar hur turbulent flödesstruktur sammverkar med förbränning av högoktaniga bränslen i partiellt förblandade förhållanden genom numeriska tredimensionella flödessimuleringar. Förbränningsmoder och antändningsprocesser studeras för två olika typfall där ett flertal metoder testas med ändamålet att korrekt återge hur icke upplöst rörelsemängd växelverkar med de kemiska processThis work treats the modelling of PPC engine combustion through 3D computational fluid dynamics. In order to develop a cost-effective CFD model for the design and performance analysis of PPC engines it is important to first understand the multiple modes of combustion in PPC engines, e.g., the onset of the first ignition kernels, the propagation of the ignition/flame fronts, and the effect of charg

This thesis deals with the addition of upconversion detection to non-linear mid-infrared laser spectroscopy techniques. The techniques investigated here are degenerate four wave mixing (DFWM) and infrared polarization spectroscopy (IRPS). These techniques are useful for detecting many of the key species in combustion, such as CH4, C2H6, HCl, and HCN. These species can be probed using ro-vibrationa

Degrowth scholarship argues for multi-scalar transformations beyond the growth-oriented economic paradigm to achieve long-term socio-ecological sustainability. While the literature on degrowth has grown substantially, little has been said about how these transformations are understood in practice. By drawing upon practice theory and using performative methods, this paper explores the ways in which

Context. The Arcturus stream is an over-density of stars in velocity space and its origin has been much debated recently without any clear conclusion. The (classical) dissolved open cluster origin is essentially refuted; instead the discussions try to distinguish between an accretion, a resonant, or an external-perturbation origin for the stream. As kinematic structures are observational footprint

Background: The optimal criteria to diagnose gestational diabetes mellitus (GDM) remain contested. The Swedish National Board of Health introduced the 2013 WHO criteria in 2015 as a recommendation for initiation of treatment for hyperglycaemia during pregnancy. With variation in GDM screening and diagnostic practice across the country, it was agreed that the shift to new guidelines should be in a

The incidence of treatment-related neuroendocrine prostate cancer (t-NEPC) is rising as more potent drugs targeting the androgen signaling axis are clinically implemented. Neuroendocrine transdifferentiation (NEtD), an putative initial step in t-NEPC development, is induced by androgen-deprivation therapy (ADT) or anti-androgens, and by activation of the β2-adrenergic receptor (ADRB2) in prostate

Brettanomyces naardenensis is a spoilage yeast with potential for biotechnological applications for production of innovative beverages with low alcohol content and high attenuation degree. Here, we present the first annotated genome of B. naardenensis CBS 7540. The genome of B. naardenensis CBS 7540 was assembled into 76 contigs, totaling 11,283,072 nucleotides. In total, 5168 protein-coding seque

PurposeThe aim of the present study was to identify the most physically demanding work tasks for Swedish ground combat soldiers through the development and application of a questionnaire survey. This is the first in a series of studies aiming to describe the development process and validation of physical selection standards in the Swedish armed forces.MethodsBased on procedural documentation, comb

Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These sy

Introduction: Beverage consumption is a modifiable risk factor for type 2 diabetes (T2D), but there is insufficient evidence to inform the suitability of substituting 1 type of beverage for another. Objective: The aim of this study was to estimate the risk of T2D when consumption of sugar-sweetened beverages (SSBs) was replaced with consumption of fruit juice, milk, coffee, or tea. Methods: In the

This study examines the consequences of grade inflation at the upper secondary education level on enrolment in higher education and earnings for Sweden. Although grade inflation is unfair and may imply inefficient allocation of human resources, current knowledge of grade inflation effects on individual outcomes is scarce. One explanation is probably the challenge of measuring and estimating causal

In this work, we discuss a classification of (,Î)-Freudenthal-Kantor triple systems defined by bilinear forms and give all examples of such triple systems. From these results, we may see a construction of some simple Lie algebras or superalgebras associated with their Freudenthal-Kantor triple systems. We also show that we can associate a complex structure into these (,Î)-Freudenthal-Kantor triple

The content of obsessions in obsessive–compulsive disorder (OCD) often run contrary to the actual self of the individual experiencing them. The ego-dystonic nature of obsessions has led some researchers to propose that individuals with OCD form these false beliefs about themselves due to limited introspective access. The current study therefore aimed to extend on recent findings from non-clinical

The lower Cambrian Lagerstätte of Sirius Passet, Peary Land, North Greenland, is one of the oldest of the Phanerozoic exceptionally preserved biotas. The Lagerstätte evidences the escalation of numbers of new body plans and life modes that formed the basis for a modern, functionally tiered ecosystem. The fauna is dominated by predators, infaunal, benthic and pelagic, and the presence of abundant n

The flame dynamics in a novel, ultra-lean non-premixed model gas turbine (GT) burner flame was numerically studied using large eddy simulation (LES) coupled with probability density function (PDF) based on the Euler stochastic field (ESF) method. One non-reacting case and three reacting cases with global equivalence ratio ϕglob=1.0,0.6,0.3 were simulated. Comparison of mean flow fields and OH dist