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The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors

Native γ-trace, a small basic protein present in high concentration in cerebrospinal fluid, semen and neuroendocrine cells, but of unknown biological function, is shown to be a potent inhibitor of the cysteine proteinases papain, ficin, and human cathepsins B, H and L. It proves to be the tightest-binding protein inhibitor of cathepsin B so far discovered. The name cystatin C is proposed for γ-tra

The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate

The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely cor

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The invasion of the native wet forests of the tropical oceanic island of Tahiti (French Polynesia, South Pacific) by miconia, Miconia calvescens DC. (Melastomataceae), a tree introduced as an ornamental plant in 1937, has caused the decline of many endemic plant species following the drastic decrease of the light in the understory. Among them, the small dioiceous tree Myrsine longifolia Nadeaud (M

Beyond the Pale (Ale) : An exploration of the sustainability priorities and innovative measures in the craft beer sector

The aim of the research presented in this exploratory paper is to present the sustainability priorities and measures focused on by craft beer SMEs and to highlight a number of innovative measures pursued by brewers to promote sustainability. The materials and methods for the study included an Internet survey of craft breweries with a sustainability profile, followed by an in-depth analysis of 70 s

Surgical Education Assessment of simulators for training and selection of trainees

BackgroundApproximately 15 % of surgical patients in hospital are affected of an adverse event, which is a medical errorcaused by the health care system. Laparoscopy is the preferred surgical technique in common procedures.Societal changes with shorter working hours, patient safety and ethics demand optimisation of resources toachieve the goal of educating competent surgeons within a reasonable tiBackgroundApproximately 15 % of surgical patients in hospital are affected of an adverse event, which is a medical error caused by the health care system. Laparoscopy is the preferred surgical technique in common procedures. Societal changes with shorter working hours, patient safety and ethics demand optimisation of resources toachieve the goal of educating competent surgeons within a reasonable

Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles

The plasma metabolome is associated with multiple phenotypes and diseases. However, a systematic study investigating clinical determinants that control the metabolome has not yet been conducted. In the present study, therefore, we aimed to identify the major determinants of the plasma metabolite profile. We used ultra-high performance liquid chromatography (UHPLC) coupled to quadrupole time of fli

Efficient mm-Wave Transmitter Design in CMOS Technology

An increasing demand of higher data rates in wireless communication forces the industry to look to higher frequencies to find the required bandwidths. This thesis is about analog transmitters in CMOS for millimeter-wave communication, and it focuses on improving power amplifiers and frequency generation circuits, and increase their efficiency. This thesis starts with an introduction to millimeter-