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A new model; WORLD6 was developed. WORLD6 differs from the earlier system dynamics world models in several aspects. Several modules link the economy, materials, metals, energy, population and politics in a dynamic system. The present version is a result of a dismantling of the World3 model (Meadows et al., 1972, 1992, 2004) with an extension and substitution of its resource module and economy modu

J Thromb Haemostas 2009;7(Suppl2):abstract 672. DOI: 10.1111/j.1538-7836.2009.03473_2.x

En hållbar omställning av transportsystemet kan komma att kräva olika typer av bränslen, tekniker och infrastrukturförändringar, och som ett möjligt alternativ finns biodrivmedel. En potentiell resurs för biodrivmedelsproduktion i Sverige är svartlut, en ligninrik biprodukt från pappers- och massaindustrin, som kan förgasas och omvandlas till metanol. Mängden svartlut som finns tillgänglig begräns

J Thromb Haemostas 2009;7(Suppl2):abstract 758. DOI: 10.1111/j.1538-7836.2009.03473_2.x

J Thromb Haemostas 2009;7(Suppl2):abstract 359. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Injury that breached the physical skin barrier increases the likelihood of infection. The wound healing process is divided into hemostasis, inflammation, proliferation, and tissue remodeling. Antimicrobial peptides play a major role for the antimicrobial defense at all these stages in wound healing, but the main sources of antimicrobial peptides vary with the different stages of wound healing comi

Background: Fishing communities around Lake Victoria in sub-Saharan Africa have been characterised as a population at high risk of HIV-infection. Methods: Using data from a cohort of HIV-positive individuals aged 13–49 years, enrolled from 5 fishing communities on Lake Victoria between 2009–2011, we sought to identify factors contributing to the epidemic and to understand the underlying structure

The critical rates of extraction of some metals was explored using a methodology based on the thinking behind critical loads for sulphur and nitrogen deposition developed in Europe 1990-2010. With a long term sustainability view in mind, critical rates based on 5,000 and 10,000 years were estimated and found to widely exceed the present extraction rates. Huge advances in recycling, as well as a si

Global production rates of metals vary from iron at 1.4 billion ton per year to platinum with 200 ton per year. Resource scarcity starts to manifest itself in rising prices and supply limitations, and metal substitution has been a major argument among economists when putting considerations of resource scarcity aside. Here we investigate the potential limits to metal substitution. Present consumpti

The total resources form copper, zinc and lead was estimated from a reworking of the literature. The data was used as input to the integrated systems dynamics model BRONZE, and used to estimate the global supply of these metals and the by-products antimony, indium, germanium, tellurium, cadmium, bismuth and selenium. The runs show that copper, zinc and lead go through peak production around 2050 a

The global supply of cobalt was simulated by combining 3 different system dynamics models; BRONZE, PGM and STEEL. The present use of cobalt shows a low degree of recycling and systemic losses are significant. The reserves of cobalt are not very large (20-25 million ton extractable) as compared to metals like copper, zinc or iron, and after 2170 cobalt will have run out under a business-as-usual sc

The complement system is an ancient part of the innate immune system important for both tissue homeostasis and host defense. However, bacteria like Staphylococcus aureus (SA) possess elaborative mechanisms for evading both the complement system and other parts of the immune system. One of these evasive mechanisms-important in causing chronic and therapy resistant infections-is the intracellular pe

Innovations in urban governance such as Urban Living Labs (ULL) are expected to accelerate the transition towards more sustainable and climate-resilient cities. This article reviews different ULL across Europe and explores the role and potential capacity of municipalities in the development of and/or facilitation of ULL as a form of experimental governance. It focuses on the role of the public sec

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master- switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical- generating subunit. The ATP-co

J Thromb Haemostas 2009;7(Suppl2):abstract 428. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Silicon (Si) is the second most abundant element in the Earth’s crust and is an important nutrient in the ocean. The global Si cycle plays a critical role in regulating primary productivity and carbon cycling on the continents and in the oceans. Development of the analytical tools used to study the sources, sinks, and fluxes of the global Si cycle (e.g., elemental and stable isotope ratio data for