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Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated the therapeutic potential of MCC950, a specific, small-molecule inhibitor of

Poor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination a

Background: Creativity is a multifaceted, complex, activity, and as such is an overarching function of the brain rather than being confined to a specific structure or region. Alzheimer's disease effects several cognitive domains involved in the creative process of producing art. Objective: We analyze the art of a well-known Swedish visual artist who suffered from Alzheimer's disease to determine i

Single bicycle crashes, i.e., falls and impacts not involving a collision with another road user, are a significantly underestimated road safety problem. The motions and behaviours of falling people, or fall kinematics, are often investigated in the injury biomechanics research field. Understanding the mechanics of a fall can help researchers develop better protective gear and safety measures to r

Abstract in GermanIn Die Soziallehren der christlichen Kirchen und Gruppen stellt Ernst Troeltsch ein riesiges Forschungsprogramm auf, das an der Schnittstelle von Soziologie und Theologie liegt. In Auseinandersetzung mit materialistischen und idealistischen Ansätzen erforscht er das Christentum als „Praxis“, in der theologische Ideale auf soziologische Realitäten und soziologische Realitäten auf

Abstract in GermanSecularization: An Analysis at Three Levels lässt sich als Synthese von Karel Dobbelaeres Arbeiten lesen. Er definiert Säkularisierung darin als einen Prozess, durch den Religion in Gesellschaften der Moderne mehr und mehr an Bedeutung verliert. Der Grundgedanke Dobbelaeres lautet dabei, dass Säkularisierung nach makro-, meso- und mikrosoziologischer Ebene zu differenzieren ist.

Gate-tunable Josephson junctions are interesting for quantum technology applications, such as gatemon qubits and topological Majorana-based qubits. Furthermore, high-frequency compatible geometries can be utilized for implementing electrically pumped parametric amplifiers. In this paper, we combine processing, measurements, and modeling of near-surface InGaAs Josephson field-effect transistors in

Bei Migration geht es um die Ein- und Auswanderung von Menschen. Sie ist ein Dauerphänomen der Menschheitsgeschichte. Gegenwärtig wird Migration aber als Krise gedeutet. Die Migrationsethik steht im Spannungsfeld kommunitaristischer und kosmopolitischer Gerechtigkeitsvorstellungen. Die Frage nach der Geltung von Rechten, die unter Bezug auf vielfältige Fluchtursachen ausgehandelt wird, ist für die

The far right is on the rise across Europe. In Germany, the political party Alternative für Deutschland (AfD) has had striking success in several elections, establishing itself in parliaments across the country. Although Christianity comes up in the programmes and the politics of this party, theologians in Germany have been hesitant to engage the rise of the far right. In this review, I present tw

“Tin-oxo cage” organometallic compounds are considered as photoresists for extreme ultraviolet (EUV) photolithography. To gain insight into their electronic structure and reactivity to ionizing radiation, we trapped bare gas-phase n-butyltin-oxo cage dications [(BuSn)12O14(OH)6]2+ in an ion trap and investigated their fragmentation upon soft X-ray photoabsorption by means of mass spectrometry. In

Oral biofilms, comprising hundreds of bacteria and other microorganisms on oral mucosal and dental surfaces, play a central role in oral health and disease dynamics. Streptococcus oralis, a key constituent of these biofilms, contributes significantly to the formation of which, serving as an early colonizer and microcolony scaffold. The interaction between S. oralis and the orally predominant mucin

Aims. The aim of this work is to create a complete list of sources exhibiting a long secondary period (LSP) in the ASAS-SN catalog of variable stars, and analyze the properties of this sample compared to other long period variables without an LSP. Methods. We used the period-amplitude diagram to identify the 55 572 stars showing an LSP, corresponding to 27% of the pulsating red giants in the catal

Collaborative practice among teachers, where teachers collaborate around their teaching practice, is known to optimise student learning in primary and secondary schools, where they are encouraged to create shared conceptions of vision, purpose and means. In higher education, however, studies on teachers working as teams and abandoning traditional norms of isolation and individualism around teachin

Formation of oxidized products from Δ3-carene (C10H16) ozonolysis and their gas-to-particle partitioning at three temperatures (0, 10, and 20 °C) under dry conditions (<2% RH) and also at 10 °C under humid (78% RH) conditions were studied using a time-of-flight chemical ionization mass spectrometer (ToF-CIMS) combined with a filter inlet for gases and aerosols (FIGAERO). The Δ3-carene ozonolysis p

Most epithelial ovarian cancer (EOC) patients are diagnosed with peritoneal dissemination. Cellular interactions are an important aspect of EOC cells when they detach from the primary site of the ovary. However, the mechanism remains underexplored. Our study aimed to reveal the role of chondroitin sulfate proteoglycan 4 (CSPG4) in EOC with a major focus on cell–cell interactions. We examined the e