It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the

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Our aim was to evaluate if there is a benefit in diagnostic accuracy and efficiency of viewing breast tomosynthesis (BT) image volumes presented horizontally oriented, but also to evaluate the use of a systematic search strategy where the breast is divided, and analyzed consecutively, into two sections. These image presentations were compared to regular vertical image presentation. All methods wer

Popular Abstract in Swedish En ny metod för att syntetisera avancerade kolhydrater har utvecklats. I en utvärdering har två kolhydratstrukturer, viktiga intermediat i ett nytt cancervaccin, syntetiserats.A novel promoter system IX/AgOTf (X=Cl or Br) for thioglycoside activation has been developed (paper I-II). The promoter system has been evaluated in the synthesis of two GD3 bis-lactam fragments (paper III).

The focus of the presentation is on the individual’s comprehension of “citizenship”. Study and analysis of citizenship concerns a person’s co-operative interaction with various physical and social surroundings as well as the cognitive integration of these surroundings. A person can achieve this integration through development of his abilities of judgement. Thus the aim is to make apparent the kind

It is likely that the increased popularity of wireless local area networks (WLANs) together with the continuous technological advances in wireless communication, also increase the interest for ad hoc networks. An ad hoc network is a wireless, autonomous, infrastructure-less network composed of stations that communicate with each other directly in a peer-to-peer fashion. When discussing mobile ad h

In this paper, a feature extraction method based on principal component analysis was developed for classification of the vascular access’s condition in hemodialysis patients. The assessment of the method was carried out by discriminating between before and after angioplasty sound recordings as well as before angioplasty and reference recordings. The results showed that when before and after angiop

Under natural or sexual selection, individuals with advantageous traits or combinations of traits will be more successful than their peers at surviving and/or reproducing. Provided these traits are heritable, meaning that they have a genetic basis, the traits combinations which are selected for, will increase in frequency in the population. When selection is intense and persistent, adaptive traits