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Ischemia-reperfusion injury (IRI) plays a crucial role in the development of primary graft dysfunction (PGD) following lung transplantation. A promising novel approach to optimize donor organs before transplantation and reduce the incidence of PGD is mitochondrial transplantation. In this study, we explored the delivery of isolated mitochondria in 4 hour ex vivo lung perfusion (EVLP) before transp

In Denmark, the incidence of carbapenemase-producing organisms (CPO) is increasing, and a coordinated national strategy is needed. We describe a case story of a 40-year-old woman transferred to a Danish hospital with severe complications after cosmetic surgery in the Middle East. She had an intra-abdominal infection with three different CPO, one of them co-resistant to colistin, one of the few rem

How does technological interdependence affect innovation? We address this question by examining the influence of neighbors’ innovativeness and the structure of the innovators’ network on a sector's capacity to develop new technologies. We study these two dimensions of technological interdependence by applying novel methods of text mining and network analysis to the documents of 6.5 million patents

Background: Despite known benefits of physical activity in reducing breast cancer risk, its impact on mammographic characteristics remain unclear and understudied. This study aimed to investigate associations between pre-diagnostic physical activity and mammographic features at breast cancer diagnosis, specifically mammographic breast density (MBD) and mammographic tumor appearance (MA), as well a

Background and purpose: Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel orally active Gal-3 small molecule inhibitor that has high affinity for Gal-3 >1000-fold selectively over other galectins. The aim of this study was to characterise GB1107 and galectin-3 in vitro and in vivo in the contex

Book Review

Book review

Anorexia nervosa is a chronic, progressive illness that is difficult to treat. Four years after diagnosis, less than 50% of patients have recovered, and 25% of anorexic patients progress to chronicity and invalidism. Because anorexia nervosa typically begins in adolescence, teenagers should be watched closely for signs that may reflect an eating disorder. In the early stages of the disease, though

The development of selective serotonin reuptake inhibitors and atypical antidepressants has changed the treatment of depression significantly. Newer antidepressants lack many of the side effects associated with the monoamine oxidase inhibitors (isocarboxazid, for example) and the tricyclic antidepressants, thereby increasing patient compliance. They are also less dangerous in overdose and are ofte