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Popular Abstract in Swedish Denna avhandling är en s.k. sammanläggningsavhandling och innehåller fyra delarbeten (I-IV). Dessa delarbeten är publicerade i vetenskapliga tidskrifter, utom arbete IV som är föremål för slutlig granskning inför publikation. Syftet med mina studier har varit att undersöka hur metabolismen i kroppens fettceller (adipocyter) regleras, med fokus på ett insulinkänsligt enzInsulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. In addition, upstream components

This book is about the relation between philosophy and organization in so far as it concerns organization studies. The book, then, revolves round the interplay between philosophy, organization and organization studies. The purpose is both to ask philosophically the question ‘What is organization?’ and to question the importance of this kind of philosophical questioning for the field of organizatio

The previous round-robin (RR) study on clothing evaporative resistance (Ret) has shown that the repeatability and reproducibility of clothing Ret measurements on sweating manikins were rather low. To further examine and enhance the measurement accuracy, a new strict but feasible test protocol was proposed and thoroughly examined in a new round-robin test. Eight laboratories participated in this st

In organisms encountering predictable environments, fixed development is expected, whereas in organisms that cannot predict their future environment, phenotypic plasticity would be optimal to increase local adaptation. To test this prediction we experimentally compared phenotypic plasticity in two rockyshore snail species; Littorina saxatilis releasing miniature snails on the shore, and Littorina

The cannabinoid 1 receptor (CB1R) has a well-established role in appetite regulation. Central CB1R antagonists, notably rimonabant, induced weight loss and improved the metabolic profile in obese individuals, but were discontinued due to psychiatric side-effects. The CB1R is also expressed peripherally, where its effects include promotion of liver fat accumulation, which consumes ATP. Type 2 diabe

In order to adapt to new conditions that increasing air traffic volumes bring forward, the Swedish Air Navigation Services (ANS) is going through a process of change. In order to meet the new conditions it will be necessary to be more efficient in the work of handling the air traffic. New conditions bring forward new demands, not only on technology and methods used, but also on organizational stru

The development of new materials for use in fuel cells is of importance for the probable replacement of the combustion engine by this technology in public vehicles in the future. The proton-conducting polymer electrolyte membrane is one of the main components in the fuel cell. The need for improved performance of the proton conducting membrane is large and has led to intensive research worldwide.

Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration of the melatonin pathway has been reported in circadian disorders, diabetes and autism spectrum disorders (ASD). However, very little is known about the genetic variability of melatonin receptors in humans. Here, we sequenced the melatonin receptor MTNR1A and MTNR1B, genes coding for MT1 and MT2 rece

Popular Abstract in Swedish Avhandlingens syfte är att analysera den akademiska debatten kring positiv särbehandling i USA med speciell tonvikt på de svarta amerikanernas historiska och aktuella förhållanden.Affirmative action is a contested policy in both political and academic debates in the United States. It is a policy that has been in place for over three decades and it is now seen as well entrenched in various settings of society, especially in educational and professional areas. However, in recent years affirmative action has been the target for more negative reactions, and many people are expe