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Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance. Versican is a chondroitin sulfate proteoglycan in the vascular extracellular matrix that accumulates following vascular injury and promotes smooth-muscle cell prolife
Aerosol particles exist in the atmosphere in large concentrations and have significant global climate effects. New particle formation is an aerosol particle source and, to date, its contribution to the total aerosol concentration in the atmosphere is not fully understood. This study focuses on the extension of new particle formation events that begin in Lille Valby, Denmark and travel over 70 km t
We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between prediagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. D
The banana pseudo-stem is a low-lignin-content lignocellulosic biomass that can be used for methane production. In recent years, anaerobic digestion (AD) of dried banana stems for methane production has attracted considerable attention. However, there is limited information regarding methane production from the fresh banana pseudo-stem. The direct usability of fresh banana stems as a resource for
Objectives: Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients receiving RTX with those receiving conventional therapy. Methods: Data on patients with SLE receiving RTX were taken from the International Registry for Biologics in
Purpose: Patients with a bipolar I disorder (BD-I) manic episode meeting the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria for "with mixed features" have a high incidence of suicide attempts and of anxiety, irritability, and agitation (AIA) symptoms. The aim of this analysis was to explore the relationship between suicidality and AIA symptoms in patients wi
Background: Practices regarding hospitalisation of children at diagnosis of type 1 diabetes vary both within countries and internationally, and high-quality evidence of best practice is scarce. The objective of this study was to close some of the gaps in evidence by comparing two alternative regimens for children diagnosed with type 1 diabetes: hospital-based care and hospital-based home care (HBH
Thylakoids reduce body weight gain and body fat accumulation in rodents. This study investigated whether an enhanced oxidation of dietary fat-derived fatty acids in the intestine contributes to the thylakoid effects. Male Sprague-Dawley rats were fed a high-fat diet with (n = 8) or without thylakoids (n = 8) for 2 wk. Body weight, food intake, and body fat were measured, and intestinal mucosa was
In order to cater for the increasingly complex society several countries have adopted a capabilities-based planning approach, including capability assessments, as part of their preparedness for disasters. Since the number of actors who are dependent on each other is increasing, capability assessments are made based on assumptions of other actors’ capabilities. It is therefore crucial to understand
Description and analysis of Swedish excise duties and Swedish tax policy in field of environmental friendly tax incentives
