The Atg2-Atg18 complex acts in parallel to Atg8 and regulates Atg9 recycling from phagophore assembly site (PAS) during autophagy in yeast. Here we show that in Drosophila, both Atg9 and Atg18 are required for Atg8a puncta formation, unlike Atg2. Selective autophagic degradation of ubiquitinated proteins is mediated by Ref(2)P/p62. The transmembrane protein Atg9 accumulates on refractory to Sigma

We theoretically discuss a phenomenon that we label “efficiencyism”. Efficiencyism describes a fixation on reified tenets of efficiency without questioning its assumptions and consequences. In organization and management theory efficiency is a foundational concept, which is assumed to be vital for economic success based on the optimization of input-output ratios. Based on the logic of the Jevons P

This chapter aims at discussing the main challenges of designing and implementing science, technology and innovation (STI) policies in developing countries. In particular, it addresses the problems of: a) aligning STI policies with the national economic development agenda, as well as coordinating STI policies among different ministries and other public organizations, and among diverse government l

Evaluation of anti-proliferative effect of BSA-1 and 32/26/2B in Y79 retinoblastoma cancer cells.

This thesis investigates the dissension and dividing force present with regard to dealing with the communist experience in Sweden andDenmark. It studies the manifestations and causes of this dissension and compares the ways it has been dealt with in historical culture. 38in-depth interviews with history teachers and historical scholars, belonging to two generations, have been conducted. They have

In this presentation we will discuss our recent progress on the integration of InAs/Si p-tunnel FETs (TFETs) and InAs/GaSb n-TFETs on SOI wafers. Local III-V growth is enabled by the development of Template-Assisted Selective Epitaxy (TASE) [1-4]. Both polarity devices have scaled geometries with cross-sections on the order of 30nm. The p-channel InAs/Si TFETs are developed based on our previously

Most of the last 20 years in Sweden have been mild and wet compared to the 1961-1990 climate reference period. After a few relatively cold years in the mid-1980s, practically all years have been warmer than the preceding 30 years average. During the indicated period, an increase of moisture-related problems (mould growth) was observed in ventilated attics, a moisture sensitive building part.This w

The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.