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Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, we u
For a level scheme investigation of Gd-142 an experiment with the gamma -spectrometer EUROBALLIII has been carried out and lifetimes have been measured with EUROBALL IV using the Doppler-shift attenuation method. The high-spin states have been populated in these experiments by means of the(99)Ru(Ti-48, 2p3n) reaction at a beam energy of 240MeV and the Sn-114(S-32, 2p2n) reaction at 160MeV, respect
The purpose of this study is to examine the extent to which Swiss companies engage in corporate entrepreneurship. To that end, a case study was undertaken to better understand how corporate entrepreneurship is practiced in the watch-making industry. Using a stratified sampling method, 18 corporate-level managers of Swiss watch manufacturers were interviewed over a 5-month period to determine their
Background: The addition of anthracyclines to platinum-based chemotherapy may provide benefit in survival in ovarian cancer patients. We evaluated the effect on survival of adding epirubicin to standard carboplatin and paclitaxel. Patients and methods: We carried out a prospectively randomized phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) with t
Closer examination of material of Macrorrhyncha rostrata Zetterstedt, 1851 from Sweden revealed a mixture of two closely related species of which one, M. hugoi sp. n. is described based on type material from Southern Sweden and Southern England. The new species includes all known records of M. rostrata from England and the Channel Islands. Records of M. rostrata from continental Europe need to be
The purpose of this paper is to analyse the recent changes in the forms of representation of workers and citizens in a historical and comparative perspective. The issue of exclusion from representation has been important for a long time among social scientists both with reference to citizen’s rights and to trade union coverage of insiders and outsiders. This issue became more important in the rece
This report contains derivations of a rigid double-track ground vehicle model including roll and pitch dynamics, using a Newton-Euler modeling approach. Suspension is incorporated in the model. The suspension system is modeled as a rotational spring and damper system, where the spring and damper constants for each wheel have been lumped to two constants, one for each degree of freedom. The resulti
Objectives. To investigate the caries risk profiles in young adults and to compare the risk classification using the Public Dental Service (PDS) guidelines with a risk assessment program, the Cariogram. Materials and methods. All 19-year-old patients registered at eight public dental clinics were invited to participate (n = 1699). The study group who completed the baseline examination consisted of
Abstract in UndeterminedThis paper addresses the failure of activation programmes to achieve a rapid return to work when they are directed towards the long-term ill. The empirical basis for the paper is an analysis of the outcomes for 691 individuals in Sweden chosen for a re-activation policy programme to shorten their sick leave and increase their chances of returning to work. The outcome at the
We discuss and compare four fixed parameter algorithms for finding the minimum weight triangulation of a simple polygon with (n - k) vertices on the perimeter and k vertices in the interior (hole vertices), that is, for a total of n vertices. All four algorithms rely on the same abstract divide-and-conquer scheme, which is made efficient by a variant of dynamic programming. They are essentially ba
Background: Mass screening for celiac disease (CD) as a public health intervention is controversial. Prior to implementation, acceptability to the targeted population should be addressed. We aimed at exploring adolescents' and parents' experiences of having the adolescents' CD detected through mass screening, and their attitudes towards possible future mass screening. Methods: All adolescents (n =
This antology includes 24 poems by Viktor Rydberg. Each poem has an introducing essay written by a scholar, a teacher, a journalist or an author.
Budgerigars (Melopsittacus undulatus) and Bourke's parrots (Neopsephotus bourkii) are closely related birds with different activity patterns. Budgerigars are strictly diurnal while Bourke's parrots are active in dim twilight. Earlier studies show that the intensity threshold of colour vision is similar in both species while Bourke's parrots have larger eyes with a higher density of rods than budge
Popular Abstract in Swedish Vid 1990-talets början drabbades Sverige av en omfattande lågkonjunktur. De unga som då skulle etableras på arbetsmarknaden var födda kring 1970-talets mitt. De fick erfara arbetslöshet och socialbidragstagande i avsevärt högre omfattning än någon tidigare generation i den moderna svenska välfärdsstaten. Trots ett förbättrat arbetsmarknadsläge fanns en grupp unga vuxna In the early 1990s a severe economic recession struck Sweden. The generation about to establish themselves on the labour market at this time were born in the mid seventies. They experienced unemployment and welfare dependency to a considerably higher extent than any previous generation in the modern Swedish welfare state. Despite the recovery of the Swedish economy a group of young adults, now in
A small-angle X-ray scattering (SAXS) set-up has recently been developed at beamline I711 at the MAX II storage ring in Lund (Sweden). An overview of the required modifications is presented here together with a number of application examples. The accessible q range in a SAXS experiment is 0.009-0.3 A(-1) for the standard set-up but depends on the sample-to-detector distance, detector offset, beams
The complement system is activated in the vasculature during thrombotic and inflammatory conditions. Activation may be associated with chronic inflammation on the endothelial surface leading to complement deposition. Complement mutations allow uninhibited complement activation to occur on platelets, neutrophils, monocytes, and aggregates thereof, as well as on red blood cells and endothelial cells
Popular Abstract in Swedish Cancer är ett laddat ord, och för de flesta av oss är cancern inte längre bort än hos en nära släkting eller vän. Trots den gemensamma benämningen, är cancer är inte bara en sjukdom, utan ca 200 olika som alla har gemensamt att cellerna börjar dela sig okontrollerat. Cancer är väldigt vanligt och uppskattningsvis kommer var tredje person att drabbas av cancer under sin Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several
Objective. To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. Design. Register study based on prospectively collected data in relation to delivery. Setting. Swedish Health Registers. Population. All pregnant women (n = 848,468) and all infants born (n = 861,989)
