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Extracellular vesicles released from microglia after palmitate exposure impact brain function

Dietary patterns that include an excess of foods rich in saturated fat are associated with brain dysfunction. Although microgliosis has been proposed to play a key role in the development of brain dysfunction in diet-induced obesity (DIO), neuroinflammation with cytokine over-expression is not always observed. Thus, mechanisms by which microglia contribute to brain impairment in DIO are uncertain.

Experimental and kinetic modeling study of the laminar burning velocity of CH4/H2 mixtures under oxy-fuel conditions

The oxy-fuel combustion of coke oven gas generates CH4/H2/O2/CO2 mixtures, and this study focuses on measuring the laminar burning velocities of these mixtures which are rarely studied previously. The investigation encompasses a range of equivalence ratios from 0.6 to 1.5, O2/(O2 + CO2) ratios varying between 0.25 and 0.38, and H2/(H2 + CH4) ratios ranging from 0.25 to 0.6, under normal temperatur

Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury

Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jon

An explainable machine learning model to solid adnexal masses diagnosis based on clinical data and qualitative ultrasound indicators

Background: Accurate characterization of newly diagnosed a solid adnexal lesion is a key step in defining the most appropriate therapeutic approach. Despite guidance from the International Ovarian Tumor Analyzes Panel, the evaluation of these lesions can be challenging. Recent studies have demonstrated how machine learning techniques can be applied to clinical data to solve this diagnostic problem

Alveolar Hemorrhage in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Results of an International Randomized Controlled Trial (PEXIVAS)

Rationale: Diffuse alveolar hemorrhage (DAH) is a life-threatening manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The PEXIVAS (Plasma Exchange and Glucocorticoids in Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis) (NCT00987389) trial was the largest in AAV and the first to enroll participants with DAH requiring mechanical ventilation. Objectives

Design of Flexible Code Block Comparisons to Improve Code Review of Refactored Code

Code review occupies a significant amount of developers’ work time and is an established practice in modern software development. Despite misaligments between users’ goals and the code review tools and processes pointed out by recent research, the code review tooling has largely stayed the same since the early 90s. Improving these tools, even slightly, has the potential for a large impact spread o

Improving the representation of tropical wetlands in LPJ-GUESS

Tropical wetlands are considered to be the greatest source of wetland-associated methane emissions. Yet, their representation in bottom-up modelling approach is oversimplified in many cases, leading to low confidence in current and future attribution attempts. The LPJ-GUESS dynamic global ecosystem model (DGVM) combines a detailed representation of high-latitude peatlands with a primitive placehol

The prognostic value of programmed death-ligand 1 (PD-L1) expression in resected colorectal cancer without neoadjuvant therapy - differences between antibody clones and cell types

BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal cancer (CRC). This study aimed to evaluate PD-L1 as a prognostic biomarker in CRC by comparing three different antibody clones.METHODS: Patients surgically treated for CRC between Ja

Sanktioner på affärsrättens område : Skadestånd, sanktionsavgifter, viten m.m.

Affärsrättsligt Centrum vid Lunds universitet (ACLU) bedriver forsknings- och seminarieverksamhet på centrala förmögenhetsrättsliga områden. En viktig del av den verksamhet som bedrivs inom ACLU är att regelbundet publicera böcker som består av originalbidrag från forskare och praktiker som har anknytning till ACLU. Målsättningen för ACLU:s publikationer är att de ska belysa aktuella och praktiskt

Ciita Regulates Local and Systemic Immune Responses in a Combined rAAV-α-synuclein and Preformed Fibril-Induced Rat Model for Parkinson’s Disease

Background: Parkinson's disease (PD) is characterized by alpha-synuclein (α-Syn) pathology, neurodegeneration and neuroinflammation. Human leukocyte antigen (HLA) variants associated with PD and α-Syn specific CD4+ T lymphocytes in PD patients highlight the importance of antigen presentation in PD etiology. The class II transactivator (CIITA) regulates major histocompatibility complex class II (MH

Parameter study of railway-induced structural vibrations using numerical and semi-analytical models

As the importance of sustainability increases more weight is laid upon using both greener building materials and efficient transportation systems. As more and more buildings are being built with wood and other light weight materials, and ever more slender constructions, the need to understand the impact of vibrations in these types of structures increases. Furthermore the increasing urban density

Entrepreneurship education scholarship in the 1990s and early 2000s : a historical analysis of the internationalizing entrepreneurship education and training conference

In this study, we contribute to research on the history of entrepreneurshipeducation scholarship in the 1990s and early 2000s byfocusing on the Internationalizing Entrepreneurship Education andTraining Conference (IntEnt conference). Acknowledging the pioneeringinitiative of the IntEnt conference in a formative phase ofthe development of entrepreneurship as a teaching subject, ourstudy delves into

Navigating Orkanen - Exploring the Spatal production of Malmö University

This thesis explores the application of Henri Lefebvre’s theory of the social production of space to the analysis of Malmö University more specifically Orkanen, the name of one of the two main buildings of the university. With a particular focus on how conceived, perceived, and lived spaces interact within the university’s neoliberal context. Through a combination of Schwarze’s operationalization

Do butchers dream of post-animal beef? A discourse analysis of the protein transition in Spain

Currently, multiple environmental crises threaten to irreversibly alter the living conditions that humanity has enjoyed on Earth for millennia. One of the main activities that contribute to these worrying environmental issues is the production and consumption of meat, which also poses serious public health and ethical concerns. In order to tackle these issues, a strong case has been made for the n

Clara's Arc(h): Navigating Higher Tides and Stronger Currents in a New Climate Norm

In the Age of Climate Disaster, 2024 has already branded itself as a record-breaking year in terms of environmental impacts. Extreme temperatures, drought, wildfires, earthquakes, floods, and rising sea levels are becoming a dire reality for many communities, and climate adaptation has become a widely discussed topic both within and outside the field of architecture. Clara’s Arc(h) is a utopian d