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SUSD4 – en bröstcancerhämmare som inducerar självkannibalism SUSD4 (sushi domain-containing protein 4) identifierades till följd av att det mänskliga genomet sekvenserades, men har sedan dess förblivit ett relativt ostuderat protein vars funktioner i celler ännu inte karaktäriserats. SUSD4 har tidigare beskrivits som en bröstcancerhämmare då dess närvaro i cancerceller har förknippats med en bätt

Norge drabbas årligen av hundratals jordskred vilket leder till betydande ekonomisk skada och fara för liv. Därför bedriver norska myndigheter och forskningsinstitutioner omfattande forskning om jordskred och vidtar åtgärder för att övervaka, modellera och slutligen mildra konsekvenserna av och förebygga dessa. Som en del av sitt arbete underhåller norska vattenresurs- och energimyndigheten en natNorway experiences hundreds of landslides annually which leads to significant economic losses and poses a threat to human life. Therefore, Norwegian authorities and scientific institutions are conducting extensive research and take measures in the fields of documenting, modelling and ultimately mitigating and preventing landslides. As part of its work, the Norwegian Water Resources and Energy Dire

Guardian proteins help or hinder clumpy proteins? Proteins are products encoded by DNA in cells. They need to be folded in a certain structure to perform their function in the cell. Because of this, the proteins need a quality control system to ensure that they are folded correctly. A large group of proteins called as chaperones are important in this regard. The main role of chaperones is to fold

Vascular plant observances were compiled for 10 well-documented parishes throughout southernmost Sweden from published floras, herbarium specimens, modern inventories, and a large citizen-science database to provide presence/absence of species from 1800-2020 at the decade level. A regionally-specific database of species-specific plant traits and ecological indicator values was used to examine flor

The #MeToo movement sparked a massive outrage amongst women in many western countries. Nevertheless, the movement did not gain as much media attention in asian regions. Japan is one of the countries that have generated international dialogue about this phenomena. The purpose of this study is to determine why #MeToo was not as successful in Japan as in many other countries and what the little outco

The main objective of this study is to find out what kind of teaching material guitar teachers in upper secondary school use when teaching the subject ”Instrument eller sång 1” (Guitar), and what the underlying factors is for this. Four guitar teachers have told about which teaching materials they use and how these teaching materials are developed through qualitative interviews. The informants are

Immunosuppressive activities of GutMagnificTM – a probiotic product designed to rebalance the gut flora and modulate the immune system – in a model for multiple sclerosis. Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease, mediated by autoreactive T cells. These T cells specifically target neurons in the central nervous system (CNS) and destroy the surrounding myelin sheath lea

Försök i växthusmiljö för att utvärdera effektiviteten av ingrepp i mindre skala mot parkslide, Reynoutria japonica. Tack vare en ökad konnektivitet i världen via turism och handel så förflyttas många arter från sina naturliga utbredningsområden, och i vissa fall leder detta till en så kallad invasiv art. Detta är arter som sprider sig okontrollerat, är svåra att utrota när de väl är introduceradJapanese knotweed, Reynoutria japonica, is a highly invasive alien species which has spread in Europe and America since it was introduced in the middle of 1800. Its ability to outcompete and suppress native plants and combined with its resilience and regenerative properties makes it difficult to control. Therefore, multiple methods have been tried to control this plant, but with varying success. T

Denna uppsats är baserad på en översättning av kapitel 1-9 i första delen av romanen Future Popes of Ireland av den irländske författaren Darragh Martin. Efter en inledande källtextanalys baserad på modellen som beskrivs av Hellspong & Ledin i Vägar genom texten – Handbok i brukstextananalys (1997) följer ett kortare medierande avsnitt om överväganden inför översättningen, där valet av översät

For a drone to be able to navigate in an indoor environment, it needs to understand its surroundings and locate itself to be able to plan a trajectory to its final destination. This thesis aims to solve the global localization problem, i.e. estimate a drone’s position and orientation in a previously mapped indoor environment by using a monocular camera and computer vision, which is an important fi

Uppdelningen i kön är en grundläggande del av vår nutid. Det är kopplat till kropp och utseende, och inte minst till barn och deras genuskodade kläder, accessoarer och frisyrer. Syftet med denna uppsats är att undersöka föräldrars syn på barn och feminint kodade genusmarkörer samt hur det kan kopplas till en större kontext av genushierarkier och relationen mellan samhället, individen och den egna

Investigating the initiation of childhood leukemia Leukemia is a cancer of the early blood-forming cells, causing a rise in the number of white blood cells in your body. These extra white blood cells can’t fight an infection the way normal white blood cells do. This also causes a reduction on red blood cells, that supply oxygen, and also a reduction on platelets that clot the blood. Due to this

Lack of oxygen delivery to the cells results in excessive production of oxygen free radicals in the cells leading to a pathological condition postulated as hypoxia. One of the most crucial transcription factors that can adapt to the fluctuating levels of hypoxia is Hypoxia Inducible Factor-1α (HIF-1α). Chronic obstructive pulmonary disease (COPD) is amongst the common lung diseases majorly caused

Kan virus skydda oss från tarminflammation? En generell uppfattning är virus gör oss sjuka, men faktum är att vår tarm alltid är fylld av biljontals mikroorganismer, allt från bakterier till virus och svamp. Hur kommer det sig då att vi inte är konstant sjuka? Anledningen är att vi lever i symbios med mikroorganismerna. En störning i denna balans kan göra oss sjuka, det kan till och med resulteraIn recent time the prevalence of inflammatory bowel diseases (IBDs) has increased, especially in developed countries. In these diseases the gut homeostasis is disturbed due to multiple factors such as the hosts own immune system, environmental factors, as well as genetic predisposition. The microbiome has previously shown to be important for the maintenance of the gut homeostasis. Despite being le

Unilateral coercive measures are a foreign policy tool that are thousands of years old and used by states in response to foreign policy concerns. Their use has become more common throughout the 21st Century, and this raises concerns from a human rights perspective. The purpose of this thesis is to demonstrate that unilateral coercive measures exacerbate suffering and add additional human rights vi

Kan fysisk träning förbättra T-cellers anti-tumörfunktion? Att träning har mängder av positiva påverkan på människans fysiska och psykiska hälsa råder inget tvivel om inom den medicinska världen. Detta har man länge kunnat påvisa genom studier på både djur, exempelvis möss, och människor som utsatts för träning. Och träning är just medicin – medicin som också påvisats ha en effekt mot den mest alDuring the last century, an increasingly sedentary lifestyle has emerged in modern societies. A lack of exercise is detrimental to global health and physical inactivity is now according to the World Health Organization the fourth leading risk factor for premature mortality. Physical inactivity is associated with increased risk of developing chronic diseases such as diabetes, cardiovascular disease

Role of SADB Kinase in DNA damage repair In the everyday life our bodies are exposed to environmental insults, such as the sunlight, which damage our genes. In addition, the cells in our body also face constant threats from within that causes damage to DNA. These damage can lead to alteration in genes and changes to the DNA molecule that can affect its ability to maintain healthiness. Luckily, ou

Amfibier i dagvattendammar — vad vet vi? Bor du i en stad men har hört grodor kväka under sommarmånaderna? Då är det inte osannolikt att de satt och ropade på varandra i en dagvattendamm. Amfibier brukar kanske inte alltid förknippas med stadsnära miljöer, men förutom att bidra med vattenrening och flödesutjämning, så kan dagvattendammar agera nattklubb och barnkammare. (För att inte tala om inseAmid an anthropogenic sixth mass extinction, amphibians are among the most threatened organism groups. This can be explained largely by the loss and fragmentation of natural wetlands due to agricultural activities and urbanisation. Stormwater retention ponds are designed both to provide flood control and to collect and purify runoff from impervious surfaces but could also serve as amphibian habita

Microcystis blooms are implicated in toxic algal blooms worldwide due to the production of toxins microcystins. Blooms have caused poisoning of humans and other animals, and annually contribute to economic loss. The biological role of microcystin synthesis by the genus Microcystis remains an unanswered question. Consequently, the factors that select for microcystin producing (toxic) phenotypes ove