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Beam shaping with 4n-order multipole magnets

A uniformly irradiating beam is beneficial in spallation for preventing irregular wear on the target. For octupoles (n = 4) and higher-order (n = 4N) magnets, passing charged-particle bunches undergo symmetric shaping effects along the x and y axes. Using a Lie-mapping formalism, we illustrate how well Gaussian distributions can be flattened symmetrically in 2D with single, dual-pulse, and RF magn

Application of whole-exome sequencing to direct the specific functional testing and diagnosis of rare inherited bleeding disorders in patients from the Öresund Region, Scandinavia

Rare inherited bleeding disorders (IBD) are a common cause of bleeding tendency. To ensure a correct diagnosis, specialized laboratory analyses are necessary. This study reports the results of an upfront diagnostic strategy using targeted whole exome sequencing. In total, 156 patients with a significant bleeding assessment tool score participated in the study, of which a third had thrombocytopenia

Approximating nonlinear forces with phase-space decoupling

Beam tracking software for accelerators typically falls into two categories: fast envelope simulations limited to linear beam optics, and slower multiparticle simulations that can model nonlinear effects. To find a middle ground between these approaches, we introduce virtual coordinates in position and momentum which have a cross-dependency (i.e. p∗ = f (x 0) where x 0 is an initial position and p

Pathophysiology of meningioma growth in pregnancy

Meningioma is among the most frequent brain tumours predominantly affecting elderly women. Epidemiological studies have shown that at the age of fertility the incidence is relatively low. The biological behaviour of meningioma in pregnancy is different from other meningiomas. The possible explanation is rooted in the complex physiological changes and hormonal differences during pregnancy. The incr

Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia

Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We hypothesized that renal expression of podocyte-specific proteins would be reflected in urinary extracellular vesicles (EVs) of podocyte origin and accompanied by increased urinary soluble nephrin levels (nephrinuria) in preeclampsia. We furth

Improved positioning and detectability of microparticles in droplet microfluidics using two-dimensional acoustophoresis

We have fabricated a silicon-glass two-phase droplet microfluidic system capable of generating sub 100 μm-sized, ø = (74 ± 2) μm, spherical droplets at rates of up to hundreds of hertz. By implementing a two-dimensional (2D) acoustophoresis particle-positioning method, we show a fourfold improvement in both vertical and lateral particle positioning inside the droplets compared to unactuated operat

Re-igniting the afterglow plasma column of an AC powered gliding arc discharge in atmospheric-pressure air

The stability and re-ignition characteristics of the plasma column of an alternating current (AC) powered gliding arc discharge operating in atmospheric-pressure air were investigated for better plasma-mode controlling and optimized applications. By modulating the AC power supply and the air flow field, the states of afterglow plasma column were varied. When pulsating the AC power supply sequence,

Panoramascener i Pappa Goriot och Röda Rummet

The article treats panorama scenes in the novels Father Goriot (1837–1843) by Honoré de Balzac and The Red Room (1879) by August Strindberg. My observations focus on the main characters Eugène de Rastignac and Arvid Falk, and the emotions that the capital arise in them where they stand in their high positions in front of Paris and Stockholm respectively; Rastignac on the hill of the Père Lachaise

Age and health-related quality of life, general self-efficacy, and functional level 12 months following dysvascular major lower limb amputation : a prospective longitudinal study

Aim: This study investigates the effect of time and age on health-related quality of life, general self-efficacy, and functional level 12 months following dysvascular major lower limb amputation (LLA). Methods: A prospective cohort study design with assessments at baseline and follow-up 3, 6, and 12 months post-amputation. Data were collected via in-person interviews using Short Form 36, the Gener

Psychometric Properties of the Spontaneous and Deliberate Mind Wandering Scales

Thinking about task-unrelated matters (mind wandering) is related to cognition and well-being. However, the relations between mind wandering and other psychological variables may depend on whether the former commence spontaneously or deliberately. The current two studies investigated the psychometric properties of the Spontaneous and Deliberate Mind Wandering Scales (SDMWS; Carriere, Seli, & S

Entropy generation analysis of fully-developed turbulent heat transfer flow in inward helically corrugated tubes

The entropy generation analysis of fully-developed turbulent heat transfer flow in inward helically corrugated tubes was numerically performed by using a Reynolds stress model. The simulations were conducted for a smooth tube and five cases of corrugated tubes with Reynolds number (Re) ranging from 10,020 to 40,060 at a constant wall temperature condition. The effects of corrugation pitch and heig

Conjugated heat transfer investigation with racetrack-shaped jet hole and double swirling chamber in rotating jet impingement

A numerical study is performed to investigate the effects of jet hole shape and channel geometry on impingement cooling for both stationary and rotating condition. Two hole shapes and two channel geometries are introduced to counteract the adverse effects of centrifugal force and Coriolis force which are induced by rotation. Both the fluid and solid part are considered for realizing the conjugate

Camera networks dimensioning and scheduling with quasi worst-case transmission time

This paper describes a method to compute frame size estimates to be used in quasi Worst-Case Transmission Times (qWCTT) for cameras that transmit frames over IP-based communication networks. The precise determination of qWCTT allows us to model the network access scheduling problem as a multiframe problem and to re-use theoretical results for network scheduling. The paper presents a set of experim

Distinctive diffusive properties of swimming planktonic copepods in different environmental conditions

Abstract.: Suspensions of small planktonic copepods represent a special category in the realm of active matter, as their size falls within the range of colloids, while their motion is so complex that it cannot be rationalized according to basic models of self-propelled particles. Indeed, the wide range of individual variability and swimming patterns resemble the behaviour of much larger animals. B

Cooper-pair splitting in two parallel InAs nanowires

We report on the fabrication and electrical characterization of an InAs double-nanowire (NW) device consisting of two closely placed parallel NWs coupled to a common superconducting electrode on one side and individual normal metal leads on the other. In this new type of device we detect Cooper-pair splitting (CPS) with a sizeable efficiency of correlated currents in both NWs. In contrast to earli