Search results

Filter

Filetype

Your search for "*" yielded 530841 hits

CKD : A Call for an Age-Adapted Definition

Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that G

Markers of renal function at admission and mortality in hip fracture patients : a single center prospective observational study

Plasma cystatin C and shrunken pore syndrome (SPS) are associated with increased mortality in older adults. The objective was to assess the association between these markers of kidney function at admission and mortality in hip fracture patients. Hip fracture patients presenting at Lund University Hospital were eligible for inclusion. Cox regression was used to assess association between plasma cys

Stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain immunoreactivity, orosomucoid and alpha 1-antitrypsin in urine stored at various conditions

Urine samples from 10 randomly selected patients with advanced renal disease were each divided into six aliquots and a preservative solution containing benzamidinium chloride, EDTA, tris(hydroxymethyl)-aminomethane and azide was then added to three of the aliquots. Aliquots with and without additive were then stored at room temperature for up to 7 days, at 4 degrees C for up to 30 days and at -20

The ‘New Urban Science’ : towards the interdisciplinary and transdisciplinary pursuit of sustainable transformations

Digitalisation is an increasingly important driver of urban development. The ‘New Urban Science’ is one particular approach to urban digitalisation that promises new ways of knowing and managing cities more effectively. Proponents of the New Urban Science emphasise urban data analytics and modelling as a means to develop novel insights on how cities function. However, there are multiple opportunit

Enhetslösningarnas tyranni

Storskalighet, centralism och likriktning. Enhetslösningarnas tyranni breder ut sig i det moderna samhället, från storföretaget till den statliga byråkratin. Men vill vi förstå – och kunna motverka – denna process måste vi söka oss bortom de vanliga uppdelningarna mellan vänster och höger och mellan stat och marknad.

Functional evolution of a bark beetle odorant receptor clade detecting monoterpenoids of different ecological origins

Insects detect odors using an array of odorant receptors (ORs), which may expand through gene duplication. How and which new functions may evolve among related ORs within a species remain poorly investigated. We addressed this question by functionally characterizing ORs from the Eurasian spruce bark beetle Ips typographus, in which physiological and behavioral responses to pheromones, volatiles fr

Predicting molecular phenotypes from histopathology images : A transcriptome-wide expression–morphology analysis in breast cancer

Molecular profiling is central in cancer precision medicine but remains costly and is based on tumor average profiles. Morphologic patterns observable in histopathology sections from tumors are determined by the underlying molecular phenotype and therefore have the potential to be exploited for prediction of molecular phenotypes. We report here the first transcriptome-wide expression–morphology (E

Is it a boy or a girl?: Who should (not) know children’s sex and why?

In this paper, we present the case of a couple who refused to disclose the sex of their child to others, and some of the responses that this case prompted in the international media. We outline the ethical issues that this case raises, and we place it into the more general context of parental preferences regarding the gender (development) of their children and of the impact on children of parental

Person centred care and shared decision making: implications for ethics, public health and research

This paper presents a systematic account of ethical issues actualised in different areas, as well as at different levels and stages of health care, by introducing organisational and other procedures that embody a shift towards person centred care and shared decision-making (PCC/SDM). The analysis builds on general ethical theory and earlier work on aspects of PCC/SDM relevant from an ethics perspe

On triparenting. Is having three committed parents better than having only two?

Although research indicates that single parenting is not by itself worse for children than their being brought up by both their parents, there are reasons why it is better for children to have more than one committed parent. If having two committed parents is better, everything else being equal, than having just one, I argue that it might be even better for children to have three committed parents

Natural versus Assisted Reproduction: In Search of Fairness

In this paper, we are concerned with the ethical implications of the distinction between natural reproduction (via sexual intercourse) and reproduction that requires assistance (either medical or social). We argue that the current practice of enforcing regulations on the latter but not on the former means of reproduction is ethically unjustified. It is not defensible to tolerate parental ignorance