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Cancer presently represents a significant global health challenge, illustrated by the high incidence and mortality rates associated with lung and breast cancer. Technological advances and concerted large-scale initiatives have yielded vast amounts of cancer data to be used for research purposes. The objective of this thesis is to capitalize on the current state of the bioinformatics field to devel
Radical right populist parties have often been treated as “pariahs,” being excluded from coalition politics in parliamentary democracies. We argue that negative rhetoric targeted at radical right populist parties in legislative debates is used by the established parties to distance themselves from such parties and that the incentives to do so depend on the political context. Using sentiment analys
Environmentally friendly InP/ZnSe core/shell quantum dots (QDs) with high absorption coefficients and tunable band gaps have demonstrated great potential for photoelectrochemical (PEC) water splitting. However, the tightly bound excitonic feature by inherent type I band alignment tends to reduce the charge separation efficiency, limiting their PEC performance. Herein, we devised heterovalent In3+
Sweden’s child welfare services are characterised by intra-organisational specialisation and collaboration with Barnahus as a standard procedure in cases of child abuse. This chapter examines what happens with social workers’ risk assessments when they are both filtered internally at different units and in relation to Barnahus and a criminal law-oriented logic. Various organisational tensions are
Treatment with the anti-angiogenic drug bevacizumab in addition to chemotherapy has shown efficacy for breast cancer in some clinical trials, but better biomarkers are needed to optimally select patients for treatment. Here, we present an omics approach where DNA methylation profiles are integrated with gene expression and results from proteomic data in breast cancer patients to predict response t
Background and Purpose: Differentiating idiopathic normal pressure hydrocephalus (iNPH) from neurodegenerative disorders such as progressive supranuclear palsy (PSP), Multiple System Atrophy—parkinsonian type (MSA-P), and vascular dementia (VaD) is challenging due to overlapping clinical and neuroimaging findings. This study assesses if quantitative brain stem and cerebellum metrics can aid in thi
Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved in a multitude of adverse health effects, such as chronic inflammatory conditions, autoimmune diseases, and cancer. Within the IL-1 family of cytokines, six—IL-1
Defining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140 items in 8 domains to foster the collection of cancer data, inform transnational cooperation and advance precision cancer medicine.
In November 2022 the European Commission launched a new regulatory framework proposal for packaging and packaging waste, EU Packaging and Packaging Waste Regulation, which includes mandatory reuse and refill targets of packed food products. With specific focus on perishable liquid food products, such as dairy, plant-based beverages, juices, and nectars, which are currently primarily available in s
Background:Rectal cancer patients commonly benefit from neoadjuvant therapy before resection surgery. For these patients, an elective ostomy diversion is frequently considered, despite the absence of conclusive evidence when a diversion is advantageous. This is a retrospective observational single-center study on a 4-year consecutive rectal cancer cohort undergoing neoadjuvant therapy, aiming at i
To reach the goals of the Paris Agreement, global emissions should be reduced to net zero by mid-century. The steel sector is an emission-intensive industrial subsector where low-carbon production routes are emerging, and recent studies have shown that rapid decarbonization of the sector is technically possible. However, several barriers block the sector-wide diffusion of low-carbon steelmaking. I
Background and objective: We investigated whether adding 4Kscore as a reflex test to prostate-specific antigen (PSA) could improve the screening algorithm for prostate cancer (PC). Methods: In the GÖTEBORG-2 PC screening trial, 38 000men (50–60 yr) were invited to PSA testing and, if elevated, followed by magnetic resonance imaging (MRI). For 571 men with PSA ≥3.0 ng/ml and evaluable outcomes, 4Ks
The article examines the formal process of ‘ethical clearance’ for social science research at a large university and illuminates how it functions to undermine its stated purpose. We find that rather than promoting ethical standards, the bureaucratic process creates negative and cynical attitudes and game playing. For almost all participants, the entire procedure is counterproductive and experience
The history of rail transport can offer valuable insights for future energy transitions due to its importance in promoting clean mobility. There is a complex interplay between the evolution of the railway network, fuel consumption, efficiency, energy service, and CO2 emissions that requires further exploration. We developed a dataset that covers energy use in all stages of rail transportation, as
In this article, I investigate how material strategies of commemoration are part of the recategorisation of public space in a series of nationalistic projects in Jerusalem and Tel Aviv. I look especially at the different ways in which these commemorative territories are made present, and the specific view of history that these presences entail. The studied cases include for example the transformat
This study constructs a Sustainable Halal Tourism Composite Performance Index (SHTCPI) to evaluate the progress of the global halal tourism industry from a sustainable tourism perspective. To create the SHTCPI, this study uses four dimensions (environment, social, economic, and halal tourism) and 24 indicators covering the 2010 to 2020 period and 116 countries. The findings suggest that halal tour
Effect of tempering temperature on the composition of the passive film of a martensitic tool alloy was studied by synchrotron-based hard/soft X-ray photoelectron spectroscopy and electrochemical analyses. The contents of Cr and Mo in the passive film are affected by precipitation of tempering carbides. Increase of tempering temperature from 200 to 525°C leads to enhanced formation of Cr/Mo-rich te
This article studies the role of shared meaning for organising Alternative Food Networks (AFNs). Extant research shows that organisational elements, such as rules, and hybridisation of conventional and alternative modes of food provisioning are important for AFN organisation. Yet, they might both enable and hinder the aims of AFNs. Complementing this body of research, the article investigates how
In order to ensure punctual and robust service, it is vital to have a good understanding of the current performance of a railway network. Several approaches to doing so exist but lack the ability to compare both service and station performance in a single dimension. The study presented here proposes the use of the Rasch analysis technique within an operational context to compare the relative dwell
Alternative fuels, such as natural and bio-gas, are attractive options for reducing greenhouse gas emissions from combustion engines. However, the naturally occurring variation in gas composition poses a challenge and may significantly impact engine performance. The gas composition affects fundamental fuel properties such as flame propagation speed and heat release rate. Deviations from the gas co
