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Combined Analysis-L1 and Total Variation ADMM with Applications to MEG Brain Imaging and Signal Reconstruction

In this article, we propose an efficient method for solving analysis-l1-TV regularization problems with a multi-step alternating direction method of multipliers (ADMM) approach as the fast solver. Additionally, we apply it to a real-data magnetoen-cephalography (MEG) brain imaging problem as well as to signal reconstruction. In our approach, the inverse problem arising in MEG or signal reconstruct

Precision cancer medicine : Concepts, current practice, and future developments

Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly com

Early Initiation of Breastfeeding and Associated Factors Among Women of Reproductive age in Simiyu Region, Tanzania

BACKGROUND: Breast milk provides infants with complete nutrition for immune development and protection against childhood diseases and associated mortality. Early initiation of breastfeeding (EIBF) aids in providing colostrum to newborns, providing protection against infection, and improving newborn and infant survival. Although Simiyu reported the lowest prevalence of EIBF in Tanzania, no study ha

Directors’ duties during the Green Transition under EU law - Reform and ramifications from corporate sustainability due diligence

In response to the climate emergency, the European Union seeks to establish a new model of inclusive growth and depicts this shift as a ‘green, fair and competitive transition’. The article examines the EU sustainable corporate governance initiative commenced in 2018 that has crystalized after 4 years in a Commission’s proposal for a Directive on corporate due diligence, which is expected to be ad

Safety and convenience of once-weekly somapacitan in adult GH deficiency: a 26-week randomized, controlled trial

ObjectiveSomapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®. Local tolerability and treatment satisfaction were also assessed.Design26-week randomized, controlled phase 3 safety and tolerability trial in six countries (Nbib2382939).Methods

Anal fistulae - Three-dimensional endoanal ultrasound and outcomes of collagen plug treatment

Bakgrund: Behandling av komplicerade analfistlar försätter att vara en stor utmaning. Tidiga studier på anal fistelplugg (AFP) visade att högt andel av patienter blir bra men senare har man rapporterad väldig varierande behandlingsframgång (13-100%) för uppföljningstider på 6-24 månader. Kunskap om de morfologiska fynd som kan relateras till framgångsrik eller misslyckad operationsresultat efter ABackground: The treatment of complex anal fistulae remains a therapeutic challenge. Early anal fistula plug (AFP) studies showed high success rates, while later reports demonstrated success rate of 13-100% at usual follow-up of 6-24 months. Very little is known about morphological findings related to success and failure of the AFP, especially if three-dimensional (3D) endoanal ultrasound (EAUS) is

Electro-thermal Models of Power Modules for Stochastic Optimization of Inverters

Stochastic optimization methods are commonly used in the design process of power electronic systems. These require models of crucial parts of the system which are both scalable and computationally efficient. This paper presents thermal models for traction inverter power modules based on scalable chip area that provide high speed of execution and accuracy. The thermal model includes chip-chip inter

Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury

Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in transcriptional initiation. When redox signaling is activated in small airway epithelial cells, the DNA r

Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Background: The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity, for application using the American College of Medical Genetics and the Association for Molecular Pathology (ACMG/AMP) var