BACKGROUND: Current models of levodopa (L-dopa)-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-dopa. However, patients with LID receive combination therapies that often include dopamine agonists.OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of L

Background: Neuroinflammation may be associated with global vascular dysfunction and damage. APOE-ε4, a major genetic risk factor for late onset AD, is expressed in neuroinflammatory cells and may lead to increased pro-inflammatory cytokine and nitric oxide production in response to injury. We examined the relationship of vascular dysfunction and damage with a magnetic resonance spectroscopy (MRS)

This chapter is a commentary on Principle 1 of the Principles for Responsible Contracts (PRC). The PRC were endorsed by the United Nations Human Rights Council in 2011 alongside the United Nations Guiding Principles on Business and Human Rights. The PRC were drafted because of the potential for investment contracts to act as an instrument through which States and businesses could affect the human

Based on conversations with young trans and nonbinary people in Sweden, in this paper I will explore how assigning emotional responsibility to gender nonconforming students is a function of cisnormative structures in schools. In the conversations, participants discussed how adults in school could require emotional support in managing their ignorance regarding gender, and how students felt required

Sibling sexual abuse constitutes a substantial proportion of sexual abuse committed by young people. The consequences for victims of sibling abuse have been found as extensive as the consequences of abuse from adults. Sibling sexual abuse also affects the entire family. However, little research has investigated sibling sexual abuse and its consequences from a parents’ perspective. This study exami

α-Synuclein (α-Syn), is an intrinsically disordered protein present in the substantia nigra part of the brain. α-Syn is commonly known to associate with lipid membranes containing anionic lipids. Hence, the protein is hypothesized to be involved in the vesicle trafficking at the synapses, but there are yet many unanswered questions regarding the full physiological role of the protein. During the d

RationaleThere is no effective disease modifying treatment for peanut allergy available. A Phase I safety and tolerability study was performed with a chemically modified, Al(OH)3 adsorbed peanut extract (HAL-MPE1) for subcutaneous immunotherapy (SCIT).MethodsIn a randomized, double-blind, placebo controlled, single-centre, Phase I study, 17 Caucasian subjects with peanut allergy were randomized to

Arbetet syftar på att utreda marksamfälligheters förutsättningar att tilldelas andelstal i en gemensamhetsanläggning, samt vilka konsekvenser en sådan anslutning medför. Målet med arbetet är dels att besvara ifall ett sådant förfarande är förenligt med anläggningslagens bestämmelser men även att studera förekomsten av anläggningsförrättningar där marksamfälligheter tilldelas andelstal i praktiken.The aim of the study is to examine the conditions for joint property units to be assigned participatory shares in a joint facility, as well as the consequences of such a procedure. The goal of the study is partly to answer if such a procedure is compatible with the rules of the law, but also to examine the occurrence of joint property units as members in joint facilities in practice. The study i

INTRODUCTION: Rapid response teams (RRTs) are designed to improve the "chain of prevention" of in-hospital cardiac arrest (IHCA). We studied the 30-day survival of patients reviewed by RRTs within 24 hours prior to IHCA, as compared to patients not reviewed by RRTs.METHODS: A nationwide cohort study based on the Swedish Registry of Cardiopulmonary Resuscitation, between January 1st, 2014, and Dece

The global agri-food system accounts for about 37% of total annual greenhouse gas (GHG) emissions, and the agri-food Small and Medium Enterprises (SMEs) share is quite significant. Therefore, it has created an urgency for GHG reporting and management improvements. However, most tools available for GHG accounting are complex to utilize and expensive for SMEs to access. The methodology adopted in th

The concept of sustainable degrowth presents itself as a normative response to some of the most pressing socio-ecological challenges of our time. The energy sector plays a prominent role in the degrowth debate, however, there is limited conceptual and empirical understanding of how energy production and consumption might look like from a degrowth perspective and which actors might be compatible wi

This study aims to investigate the feasibility of using diffuse reflectance spectroscopy (DRS) to distinguish malignant breast tissue from adjacent healthy tissue, and to evaluate if an extended-wavelength range (450–1550 nm) has an advantage over the standard wavelength range (450–900 nm). Multivariate statistics and machine learning algorithms, either linear discriminant analysis (LDA) or supporThis study aims to investigate the feasibility of using diffuse reflectance spectroscopy (DRS) to distinguish malignant breast tissue from adjacent healthy tissue, and to evaluate if an extended-wavelength range (450–1550 nm) has an advantage over the standard wavelength range (450–900 nm). Multivariate statistics and machine learning algorithms, either linear discriminant analysis (LDA) or suppor

PARP14 is a mono-ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed. We show that PARP14 is a dual-function enzyme with both ADP-ribosyl transferase and hydrolase activity act

The following case study is based on a 5-year collaborative research project that explored the multifaceted interactions between feminist and lesbian, gay, bisexual, transgender, intersex, and other (LGBTI+) activists within and across national borders in contemporary Scandinavia, Russia, and Turkey. Using a multisited, multiscalar transnational feminist approach and ethnographic methods in online

An interview with artist Christian Nyampeta about his work featured in "Is it morning for you yet?" the 58th Carnegie International.