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Improving the Developability of an Antigen Binding Fragment by Aspartate Substitutions

Aggregation can be a major challenge in the development of antibody-based pharmaceuticals as it can compromise the quality of the product during bioprocessing, formulation, and drug administration. To avoid aggregation, developability assessment is often run in parallel with functional optimization in the early screening phases to flag and deselect problematic molecules. As developability assessme

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low solubility, high viscosity and aggregation. Therefore, strategies to predict at the early phases of antibody development the risk of late-stage failure

Dietary fiber in bilberry ameliorates pre-obesity events in rats by regulating lipid depot, cecal short-chain fatty acid formation and microbiota composition

Obesity is linked to non-alcoholic fatty liver disease and risk factors associated to metabolic syndrome. Bilberry (Vaccinium myrtillus) that contains easily fermentable fiber may strengthen the intestinal barrier function, attenuate inflammation and modulate gut microbiota composition, thereby prevent obesity development. In the current study, liver lipid metabolism, fat depot, cecal and serum sh

Modeling of temperature dependence of stress-reorientation of hydrides in CWSR Zr-alloys

Hydrogen in excess of solid solubility precipitates as hydride phase of plate shaped morphology in hcp α-Zr with the broad face of the hydride plate coinciding with certain crystallographic plane of α-Zr crystal called habit plane. The objective of the present investigation is to predict the habit plane of δ-hydride precipitating in α-Zr at 298 K using strain energy minimization technique. The δ-h

Study of heavy ion beam induced damage in tungsten for high power target applications

The spallation material at ESS is pure tungsten, which is cooled by gaseous helium flow. To study the behaviour of tungsten under dynamic beam conditions at ESS, pure tungsten specimens have been irradiated at the M3-beamline of the UNILAC facility at GSI Helmholtz Centre for Heavy Ion Research. Tungsten specimens of two thicknesses, 26 μm and 3 mm, were exposed to pulsed uranium and gold ion bea

Plasma profiles of inflammatory markers associated with active tuberculosis in antiretroviral therapy-naive human immunodeficiency virus-positive individuals

Background. Diagnosis of tuberculosis (TB) in human immunodeficiency virus (HIV)-coinfected individuals is challenging. We hypothesized that combinations of inflammatory markers could facilitate identification of active TB in HIV-positive individuals. Methods. Participants were HIV-positive, treatment-naive adults systematically investigated for TB at Ethiopian health centers. Plasma samples from

Is low-level HIV-1 viraemia associated with elevated levels of markers of immune activation, coagulation and cardiovascular disease?

Objectives: The clinical significance of low-level viraemia (LLV) during antiretroviral therapy (ART) is debated. We retrospectively investigated longitudinal levels of plasma markers associated with inflammation, altered coagulation and cardiovascular disease in Swedish HIV-positive adults in relation to LLV or permanent virological suppression during long-term ART. Methods: Plasma levels of C-re