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AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b

In mantle cell lymphoma, early progression of disease has been associated with short overall survival. The impact of clinical, pathological, and treatment strategies on the risk of early relapse has not been assessed in a large cohort of patients. We performed a pooled analysis of patients recruited in France from six randomized first-line MCL trials. Among 1386 treated MCL patients, 1280 were eva

Background: As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). Destructive retinal laser treatment and intravitreal injections of anti-vascular endothelial growth factor (VEGF), factor, which have potential systemic side effects, are necessary to prevent blindness in severe cases of ROP. Of

Avoiding severe global warming requires large-scale removals of atmospheric carbon dioxide. Forest regeneration offers cost-effective carbon removals, but annual rates vary substantially by location and forest age. Here we generate grid-level (~1-km2) growth curves for aboveground live carbon in naturally regrowing forests by combining 109,708 field estimates with 66 environmental covariates. Acro

One of the most challenging problems in paleoclimate research is how orbital cyclicities forced Earth’s climate variations during the late Quaternary. To address this issue, we investigated the differences in silicate weathering, a sensitive climate indicator, at different latitudes on orbital timescales by examining geochemical and clay mineral data from the mid-latitude Sea of Okhotsk and integr

Hematopoietic stem cell (HSC) transplantation offers a cure for a variety of blood disorders, predominantly affecting the elderly; however, its application, especially in this demographic, is limited by treatment toxicity. In response, we employ a murine transplantation model based on low-intensity conditioning protocols using antibody-mediated HSC depletion. While aging presents a significant bar

High levels of circulating angiotensin converting enzyme 2 (ACE2) are associated with several chronic diseases and mortality risk. Less is known about the prognostic value of ACE2 in patients with sepsis. In the present study, we aimed to investigate the association between plasma ACE2 levels on admission to the ED and 28-day mortality, organ failure, and level of care in a prospectively recruited

Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methyla

Soil quality is fundamental to nutrient-rich food production and the sustainability of terrestrial ecosystems. However, inappropriate agricultural practices often lead to persistent soil exposure to air and sunlight, which increases soil organic matter losses and erosion risks, particularly under climate extremes. Here, we provide a satellite-based mapping of daily soil exposure occurrence across

Previous findings on results of treatment of aggression in violent offenders show inconsistent results, and implementations of such treatments have demonstrated varying success with sometimes marginal gains in forensic settings. New methods, incorporating virtual reality as a tool for experiential learning, have been put forward yet require deepened investigations concerning both treatment content

Environmental communication often abstains from irony because of the perceived negative effects on audiences. However, these views are increasingly challenged, and the frivolous term “bad environmentalism” has been adopted to question the prevailing conceptions of irony as unsuitable for environmental communication. Yet, little is known about this affective genre. Additionally, existing studies of

In this snapshot of moonlight farming in Scania, the southernmost province of Sweden, we reflect on moonlighting as a preservation strategy – a particular form of rural life different from the processes of agricultural upscaling and the rhythms and values of large-scale farming. Our immersion in the lives of three moonlight farmers tells a story of resistance, preservation and sense-scapes – a sta

Air quality apps are designed to observe air quality and inform publics about it, but also to elicit actions based on anticipated scenarios. As such, they may be seen as anticipatory technologies, cultivating environmental understandings and orienting users toward a specific future. This paper explores the anticipatory assemblages of these apps as well as users’ interactions with these apps and th

Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n

Drug resistance remains a critical challenge in cancer chemotherapy, particularly in oral squamous cell carcinoma (OSCC). Recent findings have highlighted the significant roles that autophagy and extracellular vesicles (EVs) play in contributing to chemoresistance. In previous studies, we demonstrated that EVs are essential in mediating cisplatin resistance in human OSCC cells. In this study, we s

Vår relation till miljö och natur blir alltmer beroende av digitala hjälpmedel men vad är det för data som används och vem är det som mäter?

Chlorophyll-a (Chl-a) is one of the critical water quality indicators that shows the eutrophication status of aquatic ecosystems. As the largest lake and a well-known attraction in middle Europe, Lake Balaton contributes 70 % or more of local economy through tourism, while also maintaining a unique biodiversity. Therefore, long-term monitoring of water quality is essential for its effective manage

Background: The response to the COVID-19 pandemic involved various lockdown measures, including school closures, which significantly impacted young populations, particularly in low-and middle-income countries (LMICs). Given the well-known protective effect of regular school attendance on sexual and reproductive health and rights (SRHR), reports of disrupted education, compromised SRHR, and an incr

Background: Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and social challenges. The frequent co-occurrence of psychiatric conditions, substance abuse, addiction, and homelessness highlights the complexity o

Parkinson’s disease (PD) is a complex neurodegenerative disease with a largely unknown etiology. Although the loss of dopaminergic neurons in the substantia nigra pars compacta is the pathological hallmark of PD, neuroinflammation also plays a fundamental role in PD pathology. We have previously reported that PD patients have increased frequencies of T cells reactive to peptides from α-synuclein (