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We exhibit supercritical trade-off for monotone circuits, showing that there are functions computable by small circuits for which any small circuit must have depth superlinear or even super-polynomial in the number of variables, far exceeding the linear worst-case upper bound. We obtain similar trade-offs in proof complexity, where we establish the first size-depth trade-offs for cutting planes an

Background: Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but with few studies considering chemical mixtures. Objectives: We assessed the association between fetal exposure to a mixture of EDCs and biomarkers of male fecundity in young adulthood. Materials and methods: The study population comprised 841 young adult males enrolled in the Fe

Introduction: Snus is suggested as a risk factor for cardiometabolic disease, but little is known about health effects in young populations, particularly in women. We aimed to investigate associations between snus and cardiometabolic health markers among young men and women. Aims and Methods: This study was conducted within the BAMSE (Swedish acronym for Children, Allergy, Environment, Stockholm,

Background: Vitamin D is metabolised throughout the male reproductive system, suggesting a direct regulatory role of vitamin D in male reproduction. Objectives: To investigate the association between plasma vitamin D levels at sperm ejaculation and during spermatogenesis and biomarkers of male fecundity in young men. Materials and methods: From the Fetal Programming of Semen Quality cohort, Denmar

Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular diseases in adulthood, but studies examining childhood origins are scarce. Objective: To examine associations of childhood PAH exposure with cardiometabolic risk indicators in childhood and adolescence along with differences by sex. Methods: Urinary PAH metabolites [Σ1,2,3-hydroxyphenanthrene (Σ

Pancreatic ductal adenocarcinoma (PDAC) emerges from mutant KRAS-harboring but dormant low-grade pancreatic intraepithelial neoplasia (PanIN). To examine the role of oxidative stress, a putative PDAC risk factor, we established an organoid-based transformation system. Although the prototypic oxidant H2O2 induced organoid transformation, its effect was nonmutational and was mediated by the oxidant-

Irradiation and 5-fluorouracil (5-FU) are widely utilized tools in hematopoietic research to generate myeloablation and assess blood recovery dynamics. A comprehensive understanding of their effects on the hematopoietic system is essential for optimizing therapeutic strategies, refining experimental models to modulate hematotoxicity, and interpreting research outcomes. Despite their widespread app

Birds regularly moult their feathers when they are worn from use such as mechanical wear damage due to UV exposure or accidents. Moulting generates temporary, generally symmetric, wing gaps, which can reduce flight performance by altering aerodynamic forces, lift and drag. Birds can compensate for some of these effects through mass loss, enlarged flight muscles, and adaptive wing morphing. To circ

The Swedish Research Council is a Swedish government agency and one of the major research financiers in Sweden. As such, its operations are governed by legislation and governmental instructions and policies, which prohibit discrimination and include equal treatment. Consequently, the Swedish Research Council has for a large number of years been working actively against gender bias in their reviews

Gaseous ammonia, while influential in atmospheric processes, is critically underrepresented in atmospheric measurements. This limits our understanding of key climate-relevant processes, such as new particle formation, particularly in remote regions. Here, we present highly sensitive, online observations of gaseous ammonia from a coastal site in Antarctica, which allows us to constrain the mechanis

Quantum information science has leaped forward with the exploration of high-dimensional quantum systems, offering greater potential than traditional qubits in quantum communication and quantum computing. To advance the field of high-dimensional quantum technology, a significant effort is underway to progressively enhance the entanglement dimension between two particles. An alternative effective st

To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel specimens of 23 children operated on for rectosigmo

Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor

Introduction: The PI*Mmalton variant is a rare form of alpha-1-antitrypsin (AAT) deficiency, caused by a mutation in the SERPINA1 gene and associated with reduced AAT levels. Its clinical significance remains uncertain due to the limited number of reported cases. Methods: This study characterizes PI*Mmalton carriers within the EARCO (European Alpha-1 Antitrypsin Research Collaboration) registry an

BACKGROUND: A limited subset of patients undergoing Roux-en-Y gastric bypass (RYGB) may develop intractable symptoms that ultimately require reversal to normal anatomy. Existing literature on this subject is characterized by small cohort sizes, substantial variation in surgical techniques, and limited follow-up durations. However, this study presents the largest single-center series to date, compr

BACKGROUND: Shared decision-making (SDM) between clinicians and patients is one of the pillars of the modern patient-centric philosophy of care. This study aims to explore SDM in the discipline of trauma and emergency surgery, investigating its interpretation as well as the barriers and facilitators for its implementation among surgeons.METHODS: Grounding on the literature on the topics of the und

The metrology of attosecond pulse trains is based on a cross-correlation technique between a comb of extreme ultraviolet harmonics generated by the high-order harmonic generation process and a synchronised infrared field. The approach, usually referred to as reconstruction of attosecond beating by interference of two-photon transitions (RABBIT), allows one to recover the relative phase between the

BACKGROUND: Artificial intelligence (AI) is gaining traction in medicine and surgery. AI-based applications can offer tools to examine high-volume data to inform predictive analytics that supports complex decision-making processes. Time-sensitive trauma and emergency contexts are often challenging. The study aims to investigate trauma and emergency surgeons' knowledge and perception of using AI-ba