OBJECTIVE: This study explored the association of patients' demographics, health status, symptom severity, previous osteoarthritis (OA) care, and psychological status with the change in pain severity following a first-line intervention including education and exercise for OA provided nationwide in Swedish primary care. METHODS: This register-based cohort study included 23,309 people with knee or h

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the benefits and harms of opioid analgesics in neonates (term or preterm) receiving mechanical ventilation, compared to placebo, no drug, other opioids, other analgesics or sedatives.

Human papillomavirus 16 (HPV16) 5'-splice site SD226 and 3'-splice site SA409 are required for production of the HPV16 E7 mRNAs, whereas unspliced mRNAs produce E6 mRNAs. The E6 and E7 proteins are essential in the HPV16 replication cycle but are also the major HPV16 proteins required for induction and maintenance of malignancy caused by HPV16 infection. Thus, a balanced expression of unspliced an

Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and phy

Survival data for pancreatic cancer are usually based on actuarial calculations and actual long-term survival rates are rarely reported. Here we use population-level data from the Surveillance, Epidemiology, and End Results program for patients with microscopically confirmed pancreatic ductal adenocarcinoma diagnosed from 1975 to 2011. A total of 84,275 patients with at least 5 years of follow-up

Introduction: Trypanosoma cruzi, the causative agent of Chagas disease, can infect almost any nucleated cell in the mammalian host. Although previous studies have described the transcriptomic changes that occur in host cells during parasite infection, the understanding of the role of post-transcriptional regulation in this process is limited. MicroRNAs, a class of short non-coding RNAs, are key pl

The recent open letter from the Future of Life Institute (FLI) calling for a pause on the development of AI systems has generated a significant amount of discussion. We argue that more significant action to address the potential dangers of large, generative models, requires increased efforts on AI governance, and research funding structures to build a sustainable basis for transparent research on

This thematic session addresses the theme of the conference on “Rethinking tourism for a sustainable future” by examining the paradoxes, challenges, and possibilities of sustainable tourism as modes promotion and consumption. The session invites conceptual and empirical research papers that critically intervene in ongoing discussions on tourism as a cultural and spatial phenomenon in the intersect

I rapporten ”Lärande genom temporär organisering – projekt, piloter och experiment i Malmö Stad” analyseras förutsättningarna för att främja organisatoriskt lärande genom temporära organisationer, såsom piloter, testmiljöer, och projekt, inom Malmö stad.

Space for Peace is a Special Issue that advances the spatial turn in peace and conflict studies. It brings to the fore the purchase of using space as an analytic category by advancing spatial theorization and providing empirical case studies. This introduction draws out the main tenets of spatial approaches and responds to the question: Why space? Moreover, it outlines the chapters in the Special

The global surge in plastic production, particularly single-use packaging, has triggered pressing environmental and health concerns. Addressing this crisis necessitates transformative shifts within the plastic packaging system, prioritizing the reduction, reuse, and recycling of plastic packaging. The European Union (EU) has initiated a Plastic Strategy to combat the plastic issue. This study eval

Klimatförändringar förväntas leda till längre brandperioder och ökad brandrisk. I Sverige, där homogen produktionsskog utgör största delen av landskapet, finns ett behov av bättre förståelse för skogens mottaglighet för bränder för att kunna mildra risker. I denna avhandling avser skogsbrandmottaglighet sannolikheten för att skogen brinner efter att antändning har ägt rum och inledande brandspridnClimate change is expected to result in longer fire seasons and increased fire risk. In Sweden, where homogenous production forest makes up the majority of the landscape, there is a need for better understanding of forest fire susceptibility in order to mitigate risk. In the context of this thesis forest fire susceptibility is the likelihood of forest burning after ignition and initial fire propag

Studies on annual settlement growth have mainly focused on larger cities or incorporated data rarely available in, or applicable to, sparsely populated areas in sub-Saharan Africa, such as aerial photography or night-time light data. The aim of the present study is to quantify settlement growth in rural communities in Burkina Faso affected by industrial mining, which often experience substantial i