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This article reports on a Small-N study of Centre of Excellence (CoE) schemes that cover a wide variety of such schemes. The purpose is to map the ways in which strategic aims of CoE schemes relate to impacts and capacity development, and the role played by institutional arrangements such as selection, funding, evaluation, and governance in translating strategy into capacity development and other
Background: It remains unclear whether total or subtotal parathyroidectomy for secondary hyperparathyroidism yields the best outcomes. We investigated mortality, cardiovascular events, hip fracture, and recurrent parathyroidectomy after total versus subtotal parathyroidectomy in patients on renal replacement therapy. Methods: Using the Swedish Renal Registry, the surgical registry for thyroid and
Green packaging development (GPD) involves the process of developing packaging with minimized environmental impact. Over the last decade, the GPD perspective has evolved from a traditionally packaging material-focused one to a holistic one. A holistic perspective on GPD means that the different environmental requirements on packaging have to be combined so that the overall environmental impact of
OBJECTIVES: The aim of our study was to describe and compare models of intensive care follow-up in Denmark, Norway and Sweden to help inform clinicians regarding the establishment and continuation of ICU aftercare programmes.METHODS: Our study had a multi-centre comparative qualitative design with triangulation of sources, methods and investigators. We combined prospective data from semi-structure
This study examines the network of supply and use of significant innovations across industries in Sweden, 1970-2013. It is found that 30% of innovation patterns can be predicted by network stimulus from backward and forward linkages. The network is hierarchical, characterized by hubs that connect diverse industries in closely knitted communities. To explain the network structure, a preferential we
Bildtagning med magnetresonans (mangetic resonance imaging eller MRI) är en fascinerande teknik som använder magnetfält och radiovågor för att skapa detaljerade bilder av kroppens innanmäte. Tvärt om mot vad många tror så finns det ingen ”magnetröntgen” i MR-kameran, och därmed ingen skadlig joniserande strålning. Detta gör det möjligt att utföra upprepade undersökningar på friska och sjuka försök
The finance literature offers ambiguous predictions about the impact of lending relationships on the share retained by lead arrangers in syndicated loans. While some literature indicates that lending relationships can help to alleviate post contractual agency conflicts, others imply that relationship lead arrangers may use their information advantage to exploit syndicate participants. Using syndic
This paper explores whether refinancing risk is an important determinant of maturity decisions by investigating how firms with refinancing risk choose the maturity of new loans they obtain during the 2007-2009 financial crisis. The firms' refinancing risk is measured by the maturing portion of outstanding long-term debt. The result shows that firms with a high refinancing risk choose longer maturi
This paper studies the persistent effects of short-term peer exposure in a college setting. I exploit the random assignment of undergraduates to peer groups during a mandatory orientation week and follow the students until graduation. High levels of peer ability in a group harm the students’ test scores and lead to increases in the probability of early dropout; this result is driven by the adverse
Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. However, the development of new TB drugs has been plagued with high failure rates and
Leonard Talmy’s influential binary motion event typology has encountered four main challenges: (a) additional language types; (b) extensive “type-internal” variation; (c) the role of other relevant form classes than verbs and “satellites;” and (d) alternative definitions of key semantic concepts like Motion, Path and Manner. After reviewing these issues, we show that the theory of Holistic Spatial
Background: It has previously been reported that venous cannulation-induced pain (VCP) can be used to predict acute postoperative pain after laparoscopic cholecystectomy. Patients rating VCP at ≥2.0 VAS units had 3.4 times higher risk for moderate or severe pain. The purpose of this study was to evaluate if VCP scores of ≥2.0 VAS units are associated with higher risk for acute postoperative pain a
Extensive analyses of known monogenic causes of stroke by whole-exome/genome sequencing are technically possible today. We here aimed to compile a comprehensive panel of genes associated with monogenic causes of stroke for use in clinical and research situations. We systematically searched the publically available database Online Mendelian Inheritance in Man, and validated the entries against orig
Purpose: In the BRCAsearch study, unselected breast cancer patients were prospectively offered germline BRCA1/2 mutation testing through a simplified testing procedure. The purpose of the present study was to evaluate satisfaction with the BRCAsearch testing procedure and, furthermore, to report on uptake rates of prophylactic surgeries among mutation carriers. Methods: Pre-test information was pr
A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the risk of VTE recurrence and (b) validate a previously described genetic risk score (GRS) and compare its performance with the model developed in this study. Twenty-two SNPs, including establis
