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NADH- vs NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae.

Saccharomyces cerevisiae alcohol dehydrogenases responsible for NADH-, and NADPH-specific reduction of the furaldehydes 5-hydroxymethyl-furfural (HMF) and furfural have previously been identified. In the present study, strains overexpressing the corresponding genes (mut-ADH1 and ADH6), together with a control strain, were compared in defined medium for anaerobic fermentation of glucose in the pres

Trust and the Exemplary Teacher : Fundamental Conditions for Student Learning

To support learning, a sense of trust between student and teacher is required. This assumption is discussed in relation to three human conditions: the biological, the moral and the political. In the oral space of the classroom, teachers and students are dependent on these preconditions when asking: What is a we? What are we doing? What are we making? How emulation and the presence of trust play in

Modelling the ecology and evolution of communities: a review of past achievements, current efforts, and future promises

Background: The complexity and dynamical nature of community interactions make modelling a useful tool for understanding how communities develop over time and how they respond to external perturbations. Large community-evolution models (LCEMs) are particularly promising, since they can address both ecological and evolutionary questions, and can give rise to richly structured and diverse model comm

Where on earth can animals use a geomagnetic bi-coordinate map for navigation?

Many animal taxa have been shown to possess the ability of true navigation. In this study we investigated the possibilities for geomagnetic bi-coordinate map navigation in different regions of the earth by analysing angular differences between isolines of geomagnetic total intensity and inclination. In no-grid zones where isolines were running almost parallel, efficient geomagnetic bi-coordinate n

Particle trajectories in linear water waves

We prove that in linear periodic gravity water waves there are no closed orbits for the water particles in the fluid. Each particle experiences per period a backward-forward motion that leads overall to a forward drift.

Photon echo spectroscopy reveals structure-dynamics relationships in carotenoids

Based on simultaneous analysis of the frequency-resolved transient grating, peak shift, and echo width signals, we present a model for the third-order optical response of carotenoids including population dynamics and system-bath interactions. Our frequency-resolved photon echo experiments show that the model needs to incorporate the excited-state absorption from both the S-2 and the S-1 states. We

Retinal Adaptation to Changing Glycemic Levels in a Rat Model of Type 2 Diabetes

Purpose: Glucose concentrations are elevated in retinal cells in undiagnosed and in undertreated diabetes. Studies of diabetic patients suggest that retinal function adapts, to some extent, to this increased supply of glucose. The aim of the present study was to examine such adaptation in a model of type 2 diabetes and assess how the retina responds to the subsequent institution of glycemic contro

Solvent effects on the nitrogen NMR shielding and nuclear quadrupole coupling constants in 1-methyltriazoles

In this Letter, we use a discrete polarizable solvation model for a systematic analysis of the solvent effects on the nitrogen NMR shielding and nuclear quadrupole coupling constants in a series of 1-methyltriazoles. Fairly accurate predictions are found for the solvent shifts of the nitrogen NMR shielding constants. The analysis of the relative half-height widths of the resonance signal predicted

Influence of jet-jet interactions on the lift-off length in an optical heavy-duty DI diesel engine

Several investigations have reported that the lift-off length on diesel jets depends strongly on the ambient temperature. The spacing between adjacent jets is thereby expected to influence the lift-off length, as it affects the amount of hot, burned gases present between the jets. Measurements on an 8-hole nozzle in an optical diesel engine showed that the lift-off length can be transient at all t

Using vignette methodology to research the process of breach comparatively

Comparative research related to any aspect of the process of breach in either the pretrial, sentencing or release phases is relatively rare. Comparative studies of decision making in the specific context of breach process are particularly lacking. One reason for the dearth of research in this area is the many challenges presented by comparative research across different jurisdictions. This article

Fast reliable simulations of secondary settling tanks in wastewater treatment with semi-implicit time discretization

The bio-kinetic and sedimentation processes of wastewater treatment plants can be modelled by a large system of coupled nonlinear ordinary and partial differential equations (ODEs and PDEs). The subprocess of continuous sedimentation, which contains concentration discontinuities, is modelled by a degenerate parabolic conservation PDE with spatially discontinuous coefficients. A spatial discretizat

Intellectual Property Law Compliance in Europe: Illegal File Sharing and the Role of Social Norms

The current study empirically demonstrates the widely discussed gap between copyright law and social norms. Theoretically founded in the sociology of law, the study uses a well-defined concept of norms to quantitatively measure changes in the strength of social norms before and after the implementation of legislation. The ‘IPRED law’ was implemented in Sweden on 1 April 2009, as a result of the EU

Application of nitrogen fertilizer to a boreal pine forest has a negative impact on the respiration of ectomycorrhizal hyphae

Aims There is evidence that increased N inputs to boreal forests, via atmospheric deposition or intentional fertilization, may impact negatively on ectomycorrhizal (ECM) fungi leading to a reduced flux of plant-derived carbon (C) back to the atmosphere via ECM. Our aim was to investigate the impact of N fertilization of a Pinus sylvestris (L.) forest stand on the return of recently photoassimilate