Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would

A platform for rapid on-line protein digestion of protein mixtures for direct infusion to a mass spectrometer is presented. A mixture of protein A, staphylococcal enterotoxin B and cytochrome c was used as a model mixture injected on a gel filtration column and a trypsin reactor which were connected in series to a micro liquid chromatography (mu LC) system. The peptides in the column eluate were a

We study the ground-state properties of a quasi-two-dimensional Bose Einstein condensate of indirect excitons, which are confined in an anisotropic harmonic potential. Incorporating the interactions, we calculate the order parameter variationally. The difficulties in the detection of a Bose-Einstein condensate are also discussed, along with possible ways which would overcome them.

A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were prepared by mixing a pharmaceutical carrier grade of lactose with different fractions of intermediate sized and fine (i.e., micronized) lactose. A modified Hausner Ratio was obtained by measurement of the poured

Yearbook of the Swedish Linnaeus Society. Articles on Linnaues and history of biology.

A Swedish non-word repetition test for preschool children was constructed with the aim of measuring short-term phonological memory, which has been shown to correlate with language development and language proficiency. Normative data based on results for 200 children four to six years of age are presented. An item analysis of the original 30-item test resulted in a shortened 24 non-word version fou

The first ESR spectroscopic evidence of a bimolecular homolytic substitution (SH2) reaction in a 77 K solid phase was presented, where radicals were substituted for the CH3 group of methylsilane and methylgermane (CH3XD3, X = Si, Ge). The radicals were generated by in situ UV-photolysis of CD3I in the solid CH3XD3 in an ESR cavity at 77 K. Using the selectively deuterium labeled compounds, it was

We used site-directed mutagenesis to alter the specificity of human cystatin C, an inhibitor with a broad reactivity against cysteine proteinases. Nine cystatin C variants containing amino acid substitutions in the N-terminal (L9W, V10W, V10F and V10R) and/or the C-terminal (W106G) enzyme-binding regions were designed and produced in Escherichia coli. It was discovered that the inhibition profile

Man kan identifiera fem stora kundsegment på energimarknaden nämligen hushåll i småhuslägenheter, hushåll i flerbostadshusen lägenheter, fastighetsägare till flerbostadshus, unga hushåll samt medelålders och äldre hushåll. Jämfört med energiföretagens andra kundsegment inom exempelvis industri, handel, service eller myndigheter är hushållssegmenten oorganiserade. De innehåller många hushåll med be

Before 1990 environmental reporting in Sweden was a marginal and unsystematic activity undertaken by a small number of large companies in high-profile industries. The 1990's have witnessed a dramatic increase in environmental reporting practice, and today a large number of companies in almost all industries annually report considerable amounts of environmental information. Increasingly, companies

The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can

The plant enzyme sucrose synthase (SuSy; EC 2.4.1.13) catalyzes the reversible conversion of sucrose and UDP into UDP-glucose (UDP-Glc) and fructose. The enzyme exists in different isoforms and is both located in the cytosol, membrane-bound and associated to the actin cytoskeleton. We here investigate sucrose synthase from tobacco (Nicotiana tabacum L.) BY-2 heterotrophic cell suspensions. Two dif

Objective-In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently ident

This paper argues that there is a norm in the publication of quantitative management research that accepted hypotheses are conceived of as good hypotheses. This has far-reaching implications for quantitative research in that, in the worst case scenario, this norm encourages commonsensical research questions and manipulation of data in order for an article to be published. Naturally, such behavior

Temporal compressions of optical pulses and pulse trains have been performed by the photon-echo process in Tm-doped YAG at 793 nm. Single-pulse temporal compression by almost a. factor of 500 from 10 mu s to 22 ns and pulse train compression by a factor of 14 from 5 mu s to 350 ns with a high-speed frequency-tunable external-cavity diode laser are demonstrated. It is suspected that significantly h