Bicelles are tunable disk-like polymolecular assemblies formed from a large variety of lipid mixtures. Applications range from membrane protein structural studies by nuclear magnetic resonance (NMR) to nanotechnological developments including the formation of optically active and magnetically switchable gels. Such technologies require high control of the assembly size, magnetic response and therma

Att en stor mängd köpta produkter returneras är ett problem som mångai handeln finner ekonomiskt ohållbart i längden. Dessvärre är kunskapsutvecklingenkring konsumentreturer och dess hanteringsprocess mycketbegränsad. Med detta som utgångspunkt är syftet med forskningsprojektetatt utveckla ny kunskap om hur konsumentreturer och desshanteringsprocess kan bidra till värdeskapande för e-handelsföreta

We consider adaptive time discretization methods for ordinary differential equations where one aims to control the error in a quantity of interest of the form J(u) = ∫ j(u(t))dt with j : Rd -> R. In this setting we propose a new timestep controller based on local error estimates of the quantity of interest. The new method converges when the tolerance goes to zero.We experimentally compare the new

Aerosol-cloud interactions (ACI) constitute the single largest uncertainty in anthropogenic radiative forcing. To reduce the uncertainties and gain more confidence in the simulation of ACI, models need to be evaluated against observations, in particular against measurements of cloud condensation nuclei (CCN). Here we present a data set - ready to be used for model validation - of long-term observa

Brain pericytes are important to maintain vascular integrity of the neurovascular unit under both physiological and ischemic conditions. Ischemic stroke is known to induce an inflammatory and hypoxic response due to the lack of oxygen and glucose in the brain tissue. How this early response to ischemia is molecularly regulated in pericytes is largely unknown and may be of importance for future the

One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously, One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously,

Ashbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. gossAshbya gossypii is a homothallic, flavinogenic, filamentous ascomycete that starts overproduction of riboflavin and fragments its mycelium quantitatively into spore producing sporangia at the end of a growth phase. Mating is not required for sporulation and the standard homothallic laboratory strain is a MATa strain. Here we show that ectopic expression of Saccharomyces cerevisiae MATα2 in A. goss

Underavsnitt:1) Efter Sovjetunionens upplösning2) 1990-talets ekonomiska kris3) Ryska stormaktsambitioner4) Militära konflikter och utrikespolitik5) Inskränkningar i mänskliga rättigheterUnderavsnitt:1) Efter Sovjetunionens upplösning2) 1990-talets ekonomiska kris3) Ryska stormaktsambitioner4) Militära konflikter och utrikespolitik5) Inskränkningar i mänskliga rättigheter

Abdominal sepsis is associated with dysfunctional hemostasis. Thrombin generation (TG) is a rate-limiting step in systemic coagulation. Neutrophils can expell neutrophil extracellular traps (NETs) and/or microparticles (MPs) although their role in pathological coagulation remains elusive. Cecal ligation and puncture (CLP)-induced TG in vivo was reflected by a reduced capacity of plasma from septic

Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. Despite improved recognition of drug-related side effects on mitochondrial function

Hydropower is a major energy source in Sweden and proper reservoir management prior to the spring flood onset is crucial for optimal production. This requires useful forecasts of the accumulated discharge in the spring flood period (i.e. the spring-flood volume, SFV). Today's SFV forecasts are generated using a model-based climatological ensemble approach, where time series of precipitation and te

Inference of antibody gene repertoires using transcriptome data has emerged as an alternative approach to the complex process of sequencing of adaptive immune receptor germline gene loci. The diversity introduced during rearrangement of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes has however been identified as potentially affecting inference specificity. In this study,

BACKGROUND: The normal body exists in mutualistic balance with a large range of microbiota. The primary goal of this study was to establish whether there is an imbalance in the oropharyngeal flora early after hospital or ICU admittance, and whether flora differs between control, ward and critically ill patients. The secondary goal was to explore whether there are patient characteristics that can b

This paper examines a digital employee-oriented innovation program at a global IT-firm. It addresses the research question: how is the generation and promotion of employee ideas organised by the management, and what are the behavioural implications in terms of participation of such an organising? Drawing on the literature on inclusive innovation and employee-driven innovation, the authors explore