We analyzed a cohort of 599 cases of urothelial carcinoma for EGFR, ERBB2, and ERBB3 gene expression and genomic alterations. The cohort consisted of a reference set (n = 292) comprising all stages and grades and one set (n = 307) of advanced tumors. All cases were previously classified into urothelial carcinoma molecular subtypes. Genomic amplifications were established by array-CGH or in-situ hy

Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA a

Landscape air temperature thresholds (TA) and percent misclassified precipitation (error) for 12 years of meteorological observations from 40 stations across the Scandinavian Peninsula were derived and compared using both manual and geographic information system (GIS) landscape classification methods. Dew-point, wet-bulb, and wet bulb 0.5 were also tested. Both classification methods used the foll

A timber-concrete composite structure (TCC) is economically and environmentally friendly. One of the key design points of this kind of structure is to ensure the reliability of the shear connectors. The objective of this paper is to study the mechanical property of stud-groove-type connectors and to provide shear capacity equations for stud-groove connectors in timber-concrete composite structures

Current approaches to environmental protection and development on land, along rivers and coastal zones, and in marine environments are struggling to effectively promote sustainability. This is partly due to limited understanding of how ecosystems are linked, and partly due to fragmented governance and management arrangements in the continuum from source to sea that hinders cooperation and strategi

Polyporales is strongly supported as a clade of Agaricomycetes, but the lack of a consensus higher-level classification within the group is a barrier to further taxonomic revision. We amplified nrLSU, nrITS, and rpb1 genes across the Polyporales, with a special focus on the latter. We combined the new sequences with molecular data generated during the PolyPEET project and performed Maximum Likelih

Starting from the renewed interest in the enforceability of collective agreements brought by the so-called Fiat case, this essay examines the instruments introduced by collective bargaining to this end, studying their nature in both legal and economic terms. Lastly, it proposes several interventions — to be adopted through both a legislative and a collective-bargaining process — aimed at ensuring

Purpose: To investigate associated systemic diseases, other conditions, visual outcome, ocular complications and treatment in Swedish patients younger than 50 years with central retinal vein occlusion (CRVO) and reviewing the literature. Methods: Twenty-two patients with CRVO, younger than 50 years, were examined with full-field electroretinography (ERG) within 3 months after a thrombotic event, o

Objectives: Guidelines recommend a 0-hour/1-hour high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There are, however, little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0-hour/1-hour hs-cTnT strategy together

The thesis, moving from several critical points of the Italian industrial relation system, studies in which way the rules that regulate those systems can influence the competitiveness of the enterprises. For this scope are compared several European experiences such as the Italian, Spanish and French ones, with particular attention to the changes that have been put in place after the 2008 economic

A study of the nature and magnitude of private investments in India is basic not only to an understanding of India's international economic relations, but also to an assessment of the relative position of Indian industrial sector vis-à-vis the foreign sector. 1 The following discussion is confined only to tracing of some of the trends in the growth of private foreign investments in India on the ba

I review formation channels for blue stragglers. I consider how they may be produced via collisions between two single main-sequence stars, or via collisions during encounters involving binary stars. Further, I discuss how blue stragglers may be produced via the evolution of isolated binaries. Observations of globular clusters suggest that both mechanisms are contributing.

Att lära sig uttalet i ett nytt språk är för många ett mödosamt arbete. Det gäller att kunna urskilja och producera allt ifrån ljud­segment till enskilda ord och prosodiska element, att få grepp om olika uttalsvarianter och förstå relationen mellan uttal och stavning. För att nå bästa tänkbara resultat för sina individuella uttalsmål behöver inläraren ofta professionell handledning och explicit un

Spoken testimonials on Obsessive Compulsive Disorder (OCD) constitute the data for this study, which considers contrastive construal as evoked by conditional constructions (if, unless, what if) and antonymous uses of lexical items (bad-good, guilt-innocence). Unlike conditional language use for the expression of hypothetical scenarios, doubt, and catastrophizing, antonyms have not been a focus of

Objectives: Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex with both functional and non-functional gene copies and genotyping requires assays specific for functional NCF1 genes. We aimed at investigating association and function of the missense single nucleotide pol