Analyses of ESX-1 mediated inflammasome activation and cell death in mycobacterial infection
Mycobacterium tuberculosis- invades to kill Tuberculosis is a leading cause of death globally. The causative agent, Mycobacterium tuberculosis, resides primarily in so-called macrophages, a type of immune cell that normally serves to kill invading bacteria. The mycobacterial ESX-1 type VII secretion system is critical for ability of the bacterium to survive and grow in these cells. Moreover, ESX-
