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Many natural and industrial proteins are known to have properties that can result in type I hypersensitivity, however, to date, no validated test system exists that can predict the sensitizing potential of these allergens. Thus, the objective of this study was to develop a protocol based on the myeloid cell-based Genomic Allergen Rapid Detection (GARD) assay that can be used to assess and predict

Effects of oxygenated fuels on soot reduction strongly depend on the base fuel. Interesting candidates from oxygenated fuels in this respect include both n-butanol and 2,5-dimethylfuran (DMF), because they have already been used in diesel engines recently. However, information is rather limited on n-butanol and DMF added into a diesel fuel surrogate in fundamental flames to investigate the mechani

Security in organizations is no longer just a matter of having locks and alarms; it is more like a question of different dimensions of rules, perceptions and actions. The focus must return to more interpersonal relationships in security issues instead of technically advanced equipment. In facing today’s challenges, the focus must be on more interpersonal relationships in security issues than on te

Declining trust in representative institutions is considered one of the most significant political problems of our time. It is often suggested that democratic innovations—or mechanisms which aim to increase and deepen citizen participation in the political decision-making process—can help reverse this trend. However, empirical research about actual effects of participation on trust is scarce, and

Here, it is shown that when two optical frequency combs with identical mode spacing but different offset frequencies copropagate through a nonlinear optical fiber, four-wave mixing between them generates new modes. Although the spacings between the new modes depend on the difference of the offset frequencies, they appear irregular because of the large number of possible four-wave-mixing processes.

We investigate the local changes in photophysics at different microregions of a methylammonium lead bromide (MAPbBr3) perovskite crystal under illumination. Our results show that the emission from the structurally homogeneous region is blue-shifted compared to the emission from the inhomogeneous regions. The yield and spectrum of the emission from the structurally homogeneous region do not vary wi

Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The mod

Normal incidence x-ray standing wave experiments and density functional theory reveal that 3,4,9,10-perylene-tetracarboxylic-dianhydride chemisorbs on Ag(111) in a nonplanar but vertically distorted configuration. The carboxylic O atoms are 0.18±0.03 Å closer to the surface than the perylene core. The distortion is related to weak, local bonds between carboxylic O atoms and the Ag surface which ar

Boron is an attractive high-energy fuel additive. But it could not burn efficiently in practical systems due to its high ignition temperature and slow burning velocity. Finding methods to enhance the combustion of boron is desired. This work focused on the combustion characteristics of boron submicroparticles with and without plasma discharges in a hot environment supported by CH4/N2/O2 flat flame

Two photon photoluminescence (2PPL) from single crystals of methyl ammonium lead bromide (CH3NH3PbBr3, MAPbBr3) is studied. We observe two components in the 2PPL spectra, which we assign to the photoluminescence (PL) from the carrier recombination at the band edge and the recombination due to self-trapping of excitons. The PL Stokes shift of self-trapped excitons is about 100 meV from the band-ga

Pluvial flooding is a problem in many cities and for city planning purpose the mechanisms behind pluvial flooding are of interest. Previous studies seldom use insurance claim data to analyse city scale characteristics that lead to flooding. In the present study, two long time series (∼20 years) of flood claims from property owners have been collected and analysed in detail to investigate the mecha

Tendon function and homeostasis rely on external loading. This study investigates the biological mechanisms behind tendon biomechanical function and how the mechanical performance is affected by reduced daily loading. The Achilles tendons of 16 weeks old female Sprague Dawley rats (n = 40) were unloaded for 5 weeks by inducing muscle paralysis with botulinum toxin injections in the right gastrocne

OBJECTIVES: To investigate temporal trend in fall mortality among adults (aged ≥20 years) in southern Sweden using multiple cause of death data.METHODS: We examined all death certificates (DCs, n=2 01 488) in adults recorded in the Skåne region during 1998-2014. We identified all fall deaths using International Statistical Classification of Diseases (ICD)-10 codes (W00-W19) and calculated the mort

Objectives. Comparisons between remote magnetic (RMN) and manual catheter navigation for atrial fibrillation (AF) ablation have earlier been reported with controversial results. However, these reports were based on earlier generations of the RMN system. Design. To evaluate the outcomes of the most current RMN system for AF ablation in a larger patient population with longer follow-up time, 112 pat

Rhodothermus marinus, a marine aerobic thermophile, was first isolated from an intertidal hot spring in Iceland. In recent years, the R. marinus strain PRI 493 has been genetically modified, which opens up possibilities for targeted metabolic engineering of the species, such as of the carotenoid biosynthetic pathway. In this study, the carotenoids of the R. marinus type-strain DSM 4252T, strain DS

Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. The aim of this thesis was to study the role of CART in beta-cells and incretin producing L- and K-cells.Endogen