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I defend the view that circular definitions can be useful and illuminating by focusing on the fitting-attitudes analysis of value. This definition states that an item has value if and only if it is a fitting target of attitudes. Good items are the fitting targets of positive attitudes, and bad items are the fitting targets of negative ones. I shall argue that a circular version of this definition,
Hydrological modeling realism is a central research question in hydrological studies. However, it is still a common practice to calibrate hydrological models using streamflow as a single hydrological variable, which can lead to large parameter uncertainty in hydrological simulations. To address this issue, this study employed a multi-variable calibration framework to reduce parameter uncertainty i
Transfer RNAs are adaptor molecules, which decode mRNA into protein and,thereby, play a central role in gene expression. During the maturation of a primarytRNA transcript, specific subsets of the four normal nucleosides adenosine,cytidine, guanosine, and uridine are modified. The formation of a modified nucleosidecan require more than one gene product and may involve several enzymaticsteps. In the
This article uses the steady-state calculation, based on the heating degree-day method, to verify dynamicenergy simulations and estimate a building's heating energy use in early design phases. Utilizing ClimateStudio through Rhinoceros/Grasshopper, this method acts as a control, ensuring reliability of the dynamicmodel's input/output. The simulations were conducted on a single building block with
Introduction Diagnosing invasive cutaneous melanoma (CM) can be challenging due to subjectivity in distinguishing equivocal nevi, melanoma in situ and thin CMs. The underlying molecular mechanisms of progression from nevus to melanoma must be better understood. Identifying biomarkers for treatment response, diagnostics and prognostics is crucial. Using biomedical data from biobanks and population-
This study investigates patterns of innovation during two successive industrial revolutions in Sweden. “Genius engineering firms”, such as L M Ericsson, SKF and ASEA (ABB) have dominated narratives about Sweden’s industrial and innovation success. Using new long-term data series of innovation output, 1890-2016, we observe several patterns. First, we document inverted U-shaped patterns during the c
The development of newer glucose-lowering drugs for the treatment of type 2 diabetes in recent years, such as the SGLT-2 inhibitors and GLP-1 receptor agonists/analogues with well-documented clinical benefits from large trials, has influenced international guidelines. These drugs are able to reduce both macro- and microvascular events in patients with type 2 diabetes and to prevent worsening of di
Investments in rail are usually expected to improve accessibility for individuals. The value of the additional accessibility is often measured by the impact on housing prices nearby. This paper analyses the City Tunnel in Southern Sweden, a major railway investment that resulted in two new train stations in 2010: the Triangeln and Hyllie train stations. A station may affect housing prices both dir
E-scooter sharing is a potential feeder to complement public transit for alleviating the first-and-last-mile problem. This study investigates the integration between shared e-scooters and public transit by conducting a comparative analysis in 124 European cities based on vehicle availability data. Results suggest that the integration ratios of e-scooter sharing in different cities show significant
Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl
Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit
