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The polygenic background of selectively bred diabetes models mimics the etiology of type 2 diabetes. So far, three different rodent models (Goto-Kakizaki rats, Nagoya-Shibata-Yasuda mice, and Oikawa-Nagao mice) have been established in the diabetes research field by continuous selective breeding for glucose tolerance from outbred rodent stocks. The origin of hyperglycemia in these rodents is mainl
A process-oriented, performance-based cost-model for manufactured parts has been assessed in its ability to capture sustainability. Literature has been reviewed and found 108 sustainability indicators, which have been compared with the input parameters in the cost-model. Based on a gap analysis, a framework for sustainable production evaluation has been developed. The framework considers performan
Stable HCCI combustion requires a proper level of fuel reactivity. This study shows that adding ethanol as a renewable fraction to low octane gasoline decreases the reactivity of the gasoline, while adding 2-ethyl hexyl nitrate (2-EHN) can enhance the reactivity of the blend and counter the effect of ethanol.The experimental apparatus consisted of a modified CFR engine for HCCI combustion equipped
The aim of this study is to analyse how the study group method aids student entrepreneurs when developing entrepreneurial knowledge through the experiential learning process, and why it is important to stimulate peer learning in an experiential entrepreneurship education context. Due to a more experiential perspective on learning, the environment in which students learn, what students learn and whThe aim of this study is to analyse how the study group method aids student entrepreneurs when developing entrepreneurial knowledge through the experiential learning process, and why it is important to stimulate peer learning in an experiential entrepreneurship education context. Due to a more experiential perspective on learning, the environment in which students learn, what students learn and wh
In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a case-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumor. A further case-referent study of soft-tissue s
A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chloro
By focusing only on the composition of representative bodies, the traditional ‘politics of presence’ approach has inadvertently diminished the value of participation for representation. It overlooks that there exist ‘elite voters’ who reinforce discrimination against abstainers at the policy level and create obstacles for improving the lives of the marginalized. We offer a remedy to persisting pat
OBJECTIVES: Educating healthcare professionals in patient safety is essential to achieving sustainable improvements in care. This study aimed to identify the key constituents of patient safety education alongside its facilitators and barriers from a frontline perspective.METHODS: An electronic survey was sent to 592 healthcare professionals and educators in patient safety education in the United K
Most students of politics are familiar with Carl Schmitt’s definition of politics as a friend-enemy distinction. Yet, only few know of alternative conceptions of politics in interwar Germany that emphasize cooperation and legality over confrontation and decisionism. To unlock such views, this article examines the work of Hermann Heller, a social-democratic constitutional theorist, and takes a clos
In their efforts to prevent democratic backsliding, militant democrats have traditionally been sympathetic to technocratic arrangements. Does this sympathy imply a logical congruence? Comparing theories of militant democracy and epistemic technocracy (aka epistocracy), I discover a common approach to basic aspects of representative democracy. Both theories see voters as fallible or ignorant instea
This chapter examines how the practice of compulsory voting was debated in Belgium and France at the turn of the twentieth century. Two principal arguments in favour of compulsory voting stand out. One builds on the concept of ‘true’, ‘exact’ and ‘mirror’ representation. Abstention, it is argued, creates a ‘false’ and ‘corrupt’ image of majority will; by summoning all voters, parliaments will be m
The debate on militant democracy is very much consumed by the question of whether legal restrictions against antidemocratic parties are justified. By contrast, this paper gestures towards a social conception of democratic self-defence. It does so by examining Hermann Heller’s ideas on the origins and solutions to antidemocratic threats. Arguing against Schmitt’s ‘authoritarian liberalism’, Heller
Autoimmune (type 1) diabetes mellitus is a chronic disease without a cure. It affects primarily young people but may be diagnosed at any age. Strong genetic susceptibility characterizes the most common form of autoimmune diabetes in children younger than 18 years of age. Autoimmune diabetes is generally assumed to be hereditary, although the majority of patients do not have a family history of aut
