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Fiske i fjärran vatten: En studie om EU:s fiskeriavtal med utvecklingsländer

Fiskeriavtal med Europeiska unionen är en stor inkomstkälla för vissa utvecklingsländer. Intäkterna från att utländska flottor tillåts fiska på ens territorium kan ligga på 30–50 procent av statsbudgeten.I den här rapporten analyserar författarna Johan Blomquist, Cecilia Hammarlund och Staffan Waldo – samtliga verksamma vid AgriFood Economics Centre – effekterna av EU:s fiskeriavtal med länder i V

Design and Implementation of RF Kickers in MAX IV

The MAX IV facility in Lund, Sweden, consists of two storage rings for production of synchrotron radiation, and a full-energy LINAC for top-up injections. The LINAC also delivers short high-intensity electron bunches to a short pulse facility. MAX IV was inaugurated in June 2016, and the larger 3 GeV ring has been delivering light to users since November 2016. In this thesis, the design and implem

Taking gender seriously in climate change adaptation and sustainability science research : views from feminist debates and sub-Saharan small-scale agriculture

People, places, and production contributing the least to climate change will suffer the most. This calls for adaptation as a key climate change response. But adaptation is surrounded by problems. Finance is uncertain and fragmented, mainstreaming into development is complicated, and technical solutions often overshadow existing social relations and institutions. From a gender perspective, and as a

When is your experience valuable? Occupation-industry transitions and self-employment success

The literature on employee spinoffs has, for a long time, stressed the importance of industry-specific skills and experiences in explaining the success of new firms. We argue that employees also develop skills that are associated with their occupation within an industry, and that success as an entrepreneur, therefore, is also contingent on the relation between the entrepreneurs’ previous occupatio

Mitigation of Alien Crosstalk for Downstream DSL Impaired by Multiple Interferers

Alien crosstalk is one of the major impairments for copper-based transmissions. This letter outlines a method for mitigating alien crosstalk for DSL downstream transmissions impaired by multiple interference sources. The method requires a reference channel, and includes a post processing stage in which induced correlation is applied to prepare the interference at the target channel to be reasonabl

A third generation glucose biosensor based on cellobiose dehydrogenase immobilized on a glassy carbon electrode decorated with electrodeposited gold nanoparticles : Characterization and application in human saliva

Efficient direct electron transfer (DET) between a cellobiose dehydrogenase mutant from Corynascus thermophilus (CtCDH C291Y) and a novel glassy carbon (GC)-modified electrode, obtained by direct electrodeposition of gold nanoparticles (AuNPs) was realized. The electrode was further modified with a mixed self-assembled monolayer of 4-aminothiophenol (4-APh) and 4-mercaptobenzoic acid (4-MBA), by u

Time domain analysis of higher order modes induced power dissipation in accelerating cavities

We give a semi-analytical method for the calculation of the transient power and energy dissipated in the cavity walls of an accelerating structure due to the excitation of the higher order modes by a sequence of accelerating bunches. We treat the case where more than one bunch is present in the structure at the same time. The dissipated power is evaluated using the Lagrangian formalism and the dis

Pigs, unlike mice, have two distinct colonic stem cell populations similar to humans that respond to high-calorie diet prior to insulin resistance

Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker for colon cancer. However, it is not clear how HCD drives dysregulation of colon stem cell/colonocyte proliferative kinetics. We used a human-relevant pig model

Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes

Autoantibodies against the smaller isoform of glutamic acid decarboxylase (GAD) are markers for Type 1 diabetes. GAD65 autoantibody (GAD65Ab)-positive individuals in the general population are, however, mostly at low risk of developing Type 1 diabetes, suggesting that GAD65Ab phenotypes may be associated with different underlying pathogenic processes. The aim of this study was to test the hypothes

Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds

Background Differentiation between Type 1 and Type 2 diabetes in adults is difficult at diagnosis. In this study we tested the hypothesis that autoantibodies at diagnosis are predictive for insulin treatment within 3 years in patients initially not classified as Type 1 diabetes. Methods In a nationwide population-based study, blood samples were obtained from 764 patients, all diagnosed with diabet

The World Health Organization international collaborative study for islet cell antibodies

Aims/hypothesis. Islet cell autoantibodies are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. Standardisation of islet cell antibodies and the uniform reporting in International units is critical to research and the development of assays for islet cell autoantibodies as diagnostics. Methods. The suitability of a candidate serum to serve as the international standard for islet

Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies

Autoantibodies to the islet cell 65-kilodalton isoform of glutamic acid decarboxylase (GAD65) are present in most patients with type 1 diabetes mellitus years before the clinical manifestation of the disease. GAD65 autoantibodies are also present in a subset of patients with type 2 diabetes who frequently become insulin dependent. In the present study, we evaluated a new, commercially available ra

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset

Antigen-specific T cells acquire a distinctive phenotype during activation, with characteristic acquisition of surface markers and patterns of gene expression. Early after antigen stimulation, CD4+ T lymphocytes increase their surface density of the CD4 marker, a trait which has been used to identify antigen-activated cells. The recent development of MHC tetramer technologies has greatly improved

Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens

Background: Patients with insulin-dependent diabetes mellitus (IDDM) have elevated risk for periodontitis (PD) relative to subjects without diabetes. Whether refractory PD in IDDM patients is related to autoimmunity as indicated by serum glutamic acid decarboxylase autoantibody GAD Ab levels or to host bacterial immunity as reflected by serum antibody titers to periodontal pathogens is unknown. Ai

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65

The smaller isoform of glutamic acid decarboxylase, GAD65, is an important autoantigen implicated in the pathogenesis of type 1 diabetes whereas the larger isoform, GAD67 appears to play no major role. The primary difference between the two isoforms resides in the N-terminal part of the molecule including the GAD65 membrane-anchoring domain. The aim of this study was to generate mutants of the mem

Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina

The potential for using macaques to create a nonhuman diabetic model was investigated. The significant objectives were to determine a) prognosis of STZ induced permanent beta cell destruction in nonhuman primates, and b) the potential to use STZ treated animals in a model of autoimmune diabetes by following adoptively transferred lymphocytes into MHC identical macaques. Beta cell impairment was ac