The classical goals of haemophilia A treatment are to prevent bleeds, minimise the risk of long-term complications associated with joint damage, and improve quality of life by maintaining appropriate factor VIII [FVIII] levels. The dose and frequency of FVIII replacement therapies required to reduce bleeds is now known to vary amongst individuals, and may change for the same individual over time,

The realization of unique scientific phenomena in two-dimensional nanomaterials (2DNMs) has led to their applications in several electronic fields; making it imperative to understand the conduction mechanism of charge carriers in such systems. Though several studies have been conducted on 2DNMs with pristine crystallinity, the inevitable presence of defects in the crystals requires careful conside

Long-distance migration has evolved repeatedly in animals and covers substantial distances across the globe. The overall speed of migration in birds is determined by fueling rate at stopover, flight speed, power consumption during flight, and wind support. The highest speeds (500 km/day) have been predicted in small birds with a fly-and-forage strategy, such as swallows and swifts. Here, we use GL

Museomics is a valuable approach that utilizes the diverse biobanks that are natural history museums. The ability to sequence genomes from old specimens has expanded not only the variety of interesting taxa available to study but also the scope of questions that can be investigated in order to further knowledge about biodiversity. Here, we present whole genome sequencing results from the enigmatic

Major volcanic eruptions are one of the most devastating and unpredictable events for all societies past and present. Althoughmajor progress has been made by archaeologists in understanding volcanic impacts on past societies, almost all this work hasfocused on urban or settled agricultural societies. In contrast, there is a major gap in knowledge about how forager communitieswere able to respond a

Background: Kangaroo mother care including skin-to-skin care aims to overcome the negative effects of separating parents and infants and to increase the quality of care for infants and parents in need of neonatal care. In most cases where inter-hospital transport is needed, the infant is placed in a transport incubator, which increases the risk of separation due to ambulance service restrictions t

PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti

Endel Tulving's episodic memory framework emphasizes the multifaceted re-experiencing of personal events. Indeed, decades of research focused on the experiential nature of episodic memories, usually treating recent episodic memory as a coherent experiential quality. However, recent insights into the functional architecture of the medial temporal lobe show that different types of mnemonic informati

This study analyses the documentary filmmaking of Ai Xiaoming, filmmaker, literature professor, feminist and rights activist, on the issues of the Jiabiangou Rightist Labour Camp and the 2008 Sichuan earthquake. The analyses deploy Foucault’s framework of truth-telling in the three axes of subjectification, namely, knowledge, power and morality. Ai regards documentary filmmaking as a way to challe

Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytology on patient prognoses under each clinical background. We herein investigated the comprehensive impact of positive ascites cytology on patients with epithelial OvCa and the effectiveness of additiona

Made on International Women's Day 2015 in collaboration with Zeng Jinyan (writer, Hong Kong) and Liao Yiwu (Composer/Performer,Berlin) for Chinese Artist Liu Xia, wife of Liu Xiaobo, under house arrest in Beijing without charge since her husband, poet Liu Xiaobo was awarded the Nobel Peace prize in 2010, This video was made to remind her that her art may be forbidden in China but she is not is not

Climate mitigation scenarios envision considerable growth of wind and solar power, but scholars disagree on how this growth compares with historical trends. Here we fit growth models to wind and solar trajectories to identify countries in which growth has already stabilized after the initial acceleration. National growth has followed S-curves to reach maximum annual rates of 0.8% (interquartile ra

Energy audits help to increase energy efficiency in industry and have proven effective in many studies. Additional implementation support programmes providing financial incentives have been developed to not only support audits but also to overcome financial barriers to energy efficiency investments. Because the different types of programmes coexist, we argue that a precise analysis of their effect