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Serine protease inhibitors in patients with chronic viral hepatitis
BACKGROUND/AIMS: This study aimed to determine whether deficiency of the major serine protease inhibitors (alpha1-antitrypsin (AAT) or alpha1-antichymotrypsin (ACT)) is associated with increased risk for chronic hepatitis B or C virus (HBV or HCV) infection. METHODS: We studied 709 adults with chronic liver disease who had undergone liver biopsy during the 14-year period 1978-92. Anti-HCV testing
Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart.
Evaluation of Unidirectional Lateral Transshipments and Substitutions in Inventory Systems
One interpretation of the model considered in this paper is a single-echelon inventory system consisting of a number of local warehouses, which normally replenish from an outside supplier. In case of a stockout at a warehouse an emergency lateral transshipment from another warehouse may be possible. However, such transshipments are only allowed in one direction, i.e., the flow structure is unidire
Specific language impairment in Swedish: The status of verb morphology and word order
Association between biomarkers of exposure to persistent organochlorine compounds (POCs).
Serum concentrations of CB-153 and pp'-DDE were assessed for 354 men and women from the Swedish Fishermen's Families Cohort, and were found to correlate very well (Pearson's r = 0.72). In this particular cohort the main source of exposure to persistent organochlorine compounds are consumption of contaminated fatty fish. High correlations between total PCB/CB-153 and p,p'-DDE have also been found i
Reference values for the physical work capacity on a bicycle ergometer for men -- a comparison with a previous study on women.
Expression of lactate dehydrogenases A and B during chicken spermatogenesis: characterization of testis specific transcripts.
The substrates required for glycolysis change markedly at successive stages of spermatogenesis suggesting a considerable plasticity in the expression of glycolytic enzymes. Lactate dehydrogenase (LDH) isoenzymes, LDH-A and LDH-B, are expressed in premeiotic, meiotic cells, and early spermatids, both in avian and mammalian spermatogenesis. Highly polyadenylated forms, particularly of LDH-A, were de
Population genetic screening programmes: technical, social, and ethical issues.
The need for prophylaxis in von Willebrand's disease and other coagulation disorders
Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure
Background The methyl ester form of fumaric acid named dimethyl fumarate (DMF) is an effective mould-growth inhibitor. Its irritating and sensitizing properties were demonstrated in animal models. Recently, DMF has been identified as responsible for furniture contact dermatitis in Europe. Objective To describe the clinical manifestations, patch test results, shoe chemical analysis, and source of e
Laminin-1 promotes angiogenesis in synergy with fibroblast growth factor by distinct regulation of the gene and protein expression profile in endothelial cells
Laminins are widely distributed extracellular matrix proteins. Certain laminin isoforms are predominant in vascular basement membranes and may be critical in maintaining the stability of the mature vessel. On the other hand, formation of new vessels during angiogenesis requires degradation of the basement membrane, exposing the endothelial cells to other laminin isoforms in the surrounding extrace
Obtaining informed consent from patients in the early phase of acute myocardial infarction: physicians' experiences and attitudes
Benzenecarboxylate surface complexation at the goethite (alpha-FeOOH)/water interface: II. Linking IR spectroscopic observations to mechanistic surface complexation models for phthalate, trimellitate, and pyromellitate
A study combining information from infrared spectroscopy and adsorption experiments was carried out to investigate phthalate, trimellitate, and pyromellitate complexes at the goethite (alpha-FeOOH)/water interface. Infrared spectra showed evidence for inner-sphere complexes below pH 6 and outer-sphere complexes in the pH range 3 to 9. Normalized infrared peak areas were used as a semi-quantitative
Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin.
The anti-atherosclerosis mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) occur via both cholesterol-dependent and cholesterol-independent mechanisms. The present study used aortic and cerebral vascular smooth muscle cells (SMC) from rat to investigate whether atorvastatin and mevastatin affect basic fibroblast growth factor (bFGF)-induced SMC proliferation and th
Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK-7 and MK-8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age-matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 +/- 302 versus 5
The hazards of kissing when you are food allergic - A survey on the occurrence of kiss-induced allergic reactions among 1139 patients with self-reported food hypersensitivity
Background: According to a few case reports, kissing can induce symptoms due to food allergy. Objective: We wanted to investigate the occurrence of kiss-induced allergic symptoms and other social inconveniences among patients with self-reported food hypersensitivity. Methods: A questionnaire was answered by 1139 patients (1-84 years old, mean age 29 years, 393 males and 746 females) who considered
Structure of native protein C inhibitor provides insight into its multiple functions
Protein C inhibitor (PCI) is a multifunctional serpin with wide ranging protease inhibitory functions, unique cofactor binding activities, and potential non-inhibitory functions akin to the hormone-transporting serpins. To gain insight into the molecular mechanisms utilized by PCI we developed a robust expression system in Escherichia coli and solved the crystal structure of PCI in its native stat
Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.
CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive i
Studying the effects of adsorption, recoalescence and fragmentation in a high pressure homogenizer using a dynamic simulation model
The emulsification in a high pressure homogenizer was studied using a dynamic simulation model based on the population balance equation. The model includes fragmentation, recoalescence and adsorption of macromolecular emulsifier and uses a simple flow model in order to link the hydrodynamics in the homogenizer to the three physical processes mentioned above. A computer model offers an interesting