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Inflammaging and Vascular Function in Metabolic Syndrome : The Role of Hyperuricemia

Background and Objectives: Early vascular aging determines a more rapid course of age-related arterial changes. It may be induced by a proinflammatory state, caused by hyperuricemia and metabolic syndrome and their interrelationship. However, the impact of serum uric acid (SUA) on early arterial stiffening and vascular function remains uncertain. Materials and Methods: A total of 696 participants

The European Court’s Incremental Approach to the Protection of Liberty, Dignity and Autonomy

Mental health law is inextricably connected to key human rights protected under the European Convention on Human Rights (1950, ECHR or the Convention), such as the right to freedom of liberty, to personal autonomy and physical and mental integrity, and to the right to not be discriminated against. This chapter outlines the fundamental procedural and substantive standards developed by the European

Risk of severe COVID-19 from the Delta and Omicron variants in relation to vaccination status, sex, age and comorbidities - surveillance results from southern Sweden, July 2021 to January 2022

We compared the risk of severe COVID-19 during two periods 2021 and 2022 when Delta and Omicron, respectively, were the dominating virus variants in Scania county, Sweden. We adjusted for differences in sex, age, comorbidities, prior infection and vaccination. Risk of severe disease from Omicron was markedly lower among vaccinated cases. It was also lower among the unvaccinated but remained high (

Computer simulations of case difficulty in digital breast tomosynthesis using virtual clinical trials

Purpose: Virtual clinical trials (VCTs) require computer simulations of representative patients and images to evaluate and compare changes in performance of imaging technologies. The simulated images are usually interpreted by model observers whose performance depends upon the selection of imaging cases used in training evaluation models. This work proposes an efficient method to simulate and cali

Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance

Background: Physical activity remains a valuable prevention for metabolic disease. The effects of Nordic walking on cardiovascular risk factors were determined in overweight individuals with normal or disturbed glucose regulation.Methods: We included 213 individuals, aged 60 ± 5.3 years and with body mass index (BMI) of 30.2 ± 3.8 kg/m(2); of these, 128 had normal glucose tolerance (NGT), 35 had i

Misdiagnosed and maltreated scaphoid fractures – costly both for society and patients : A review of filed claims to the Swedish National Patient Insurance Company 2011–2018

• Misdiagnosed and maltreated scaphoid fractures filed to the Swedish National Patient Insurance Company (LÖF) 2011–2018 were analyzed in terms of complications and costs for society. All filed claims are database-registered (altogether 200 000 claims since 2000). This database was assessed in June 2019 through injury ICD10-SWE-diagnoses. Demographics, complications, complaints, corrective surgeri

Keeping Religion in the Closet : How Legible Religion Shapes Multi-Faith Spaces

This dissertation focuses on multi-faith spaces and the tendencies in approaching religion that lie behind them. It argues that an overarching conceptual framework exists that conditions these tendencies, and which is described in the dissertation as “legible religion.” Such a framework results from the broader administrative attempts to make different phenomena “legible,” that is, simplified and

The Effect of Nutritious School Lunches on Education, Health, and Life-Time Income

In this article we present the long-run gains of adopting a nutritious school meal program for Swedish children. During the 1960s, Sweden rolled out a universal program that provided nutritious school lunches free of charge to all children in Swedish primary schools. Our results show that the school lunch program generated substantial long-term benefits, where pupils exposed to the program during

Climate-driven variation in biotic interactions provides a narrow and variable window of opportunity for an insect herbivore at its ecological margin

Climate-driven geographic range shifts have been associated with transitions between dietary specialism and generalism at range margins. The mechanisms underpinning these often transient niche breadth modifications are poorly known, but utilization of novel resources likely depends on phenological synchrony between the consumer and resource. We use a climate-driven range and host shift by the butt

Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer

Advances in curative treatment to remove the primary tumor have increased survival of localized cancers for most solid tumor types, yet cancers that have spread are typically incurable and account for >90% of cancer-related deaths. Metastatic disease remains incurable because, somehow, tumors evolve resistance to all known compounds, including therapies. In all of these incurable patients, de novo

The generative principles of lifestyle enterprising : dialectic entanglements of capital-habitus-field

Purpose: The study seeks to shed light on the generative principles of enterprising by examining the practices of enterprisers in six lifestyle enterprises in Sweden. It presents a fresh approach to the study of lifestyle enterprises, resolving a nuanced treatment of the concepts of capital and habitus as often drawn upon in studies using the social theory of Pierre Bourdieu. Design/methodology/ap

Effect of stimulus height on cockroach optomotor response

Using tethered American cockroaches walking on a trackball in a spherical virtual reality environment, we tested optomotor responses to horizontally moving black-and-white gratings of different vertical extent under six different light intensities. We found that shortening the vertical extent of the wide-field stimulus grating within a light level weakened response strength, reduced average veloci

An Exact Ewald Summation Method in Theory and Practice

We present the widespread Ewald summation method in a new light by utilizing a truncated Gaussian screening charge distribution. This choice entails an exact formalism, also as particle mesh Ewald, which in practice is not always the case when using a Gaussian screening function. The presented approach reduces the number of dependent parameters compared to a Gaussian and, for an infinite reciproca

Nanowire Tunnel FET with Simultaneously Reduced Subthermionic Subthreshold Swing and Off-Current due to Negative Capacitance and Voltage Pinning Effects

Nanowire tunnel field-effect transistors (TFETs) have been proposed as the most advanced one-dimensional (1D) devices that break the thermionic 60 mV/decade of the subthreshold swing (SS) of metal oxide semiconductor field-effect transistors (MOSFETs) by using quantum mechanical band-to-band tunneling and excellent electrostatic control. Meanwhile, negative capacitance (NC) of ferroelectrics has b

Psychometric properties of the Connor-Davidson Resilience Scale (CD-RISC) in a non-clinical population in Sweden

Background: The Connor-Davidson Resilience Scale (CD-RISC) is the most widely used scale which assesses psychological resilience. Although it is recommended to be applied as a unidimensional scale, its factor structure, reliability, as well as discriminant and predictive validity need to be assessed when used in a new context. Moreover, the original five-factor structure has not been replicated in

Androgens in men study (AIMS) : Protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men

Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four Nort

Degrees of integration: how a fragmented entrepreneurial ecosystem promotes different types of entrepreneurs

Entrepreneurial Ecosystems (EEs) are expected to support high growth entrepreneurship. Yet, little is known about how they actually promote entrepreneurial activities. Based on Giddens’ structuration theory, this paper takes the entrepreneurs’ perspective to understand how they actually use the resources provided by an EE. Based on semi-structured interviews with entrepreneurs and other relevant a

Reviewing the material and metal security of low-carbon energy transitions

The global transition to a low-carbon economy will involve changes in material markets and supply chains on a hitherto unknown scale and scope. With these changes come numerous challenges and opportunities related to supply chain security and sustainability. To help support decision-making as well as future research, this study employs a problem-oriented perspective while reviewing academic public

Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services

Background: The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other services, including delivery of surgery. Methods: This was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint