Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection

Background and purpose — A tapered, polished and collarless stem is normally equipped with a hollow centralizer to prevent the stem from becoming end-bearing in the cement as the stem subsides. In a randomized clinical trial, we evaluated such a stem (MS-30), which was initially introduced with a solid centralizer but was later recommended to be fitted with a hollow centralizer. We hypothesized th

Background: Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. These cells are also potential target for immunotherapy as well as providing a handle to investigate immune status in the tumour microenvironment. The aim of the present study was to examine their impact on prognosis

BACKGROUND: The risk of spinal haematoma in patients receiving epidural catheters is estimated using routine coagulation tests, but guidelines are inconsistent in their recommendations on what to do when results indicate slight hypocoagulation. Postoperative patients are prone to thrombosis, and thromboelastometry has previously shown hypercoagulation in this setting. We aimed to better understand

Background: The most concerning complication of video capsule endoscopy (VCE) is capsule retention (CR) in the gastrointestinal (GI) tract although clinical outcome and management of patients with CR are still uncertain in a large single center material. Objectives: The aim of this retrospective study was to investigate incidence, causes, risk factors, management and clinical outcomes of CR in a l

The simulation of viscous, compressible flows around complex geometries or similar applications often inherit the task of solving large, stiff systems of ODEs. Domain-based implicit-explicit (IMEX) type schemes offer the possibility to apply two different schemes to different parts of the computational domain. The goal hereby is to decrease the computational cost by increasing the admissible step

An unresolved issue in innovation studies is to what extent and how innovation is affected by changes in the economic environment of firms. This study elaborates on a theoretical framework that unites theories of innovation as creative response and the economics of complexity. In the empirical section, results from a new micro-based database on Swedish product innovations, 1970–2007, are introduce

Background: Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding metformin transporters has not been fully elucidated. We examined the DNA methylation of these genes in the li

Western firms locating in China face a business environment that differs from their home country environment. The differences increase uncertainties and are negative for economic performance. However, firms may differ in their ability to overcome the difficulties, depending on their previous experience. In particular, firms with experience from regions similar to China might exhibit relatively bet

Hailed by economists as an idea whose time has come, the `new economic geography' has not been quite as favourably received by geographers. Frequently seen as a prime case of academic imperialism, few appear willing to concede that economists may have something to contribute to economic geography. Conversely, beyond the token reference to vintage publications, economistsoften dismiss geographers'

Projektets syfte är att generera kunskap om ledande företags konfigurering av värdesystem. Syftet kan delas in i fyra delar: 1 Analysera och utveckla definitioner för begreppen strategisk ekonomistyrning (SMA), interorganisatorisk ekonomistyrning (IOMA) och konfigurering. 2 Beskriva användningen och betydelen av strategisk ekonomistyrning och interorganisatorisk ekonomistyrning under konfigurering

The configuration of value chains and value systems is of vital importance for the long-term competitiveness and survival of companies. The focus of the study is value systems involving a leading Company. Our main question is: How do leading companies configure boundless value systems?

Educating Social Entrepreneurs: From Idea Generation to Business Plan Formulation appears at a time of unprecedented environmental disasters, natural resources depletion, and significant failure of governments and global businesses to attend to worldwide social problems. In this era of downsizing, restructuring, and social changes, notions of traditional venture creation and the ways of creating s

Non-suicidal self-injury (NSSI) is self-inflicted physical harm that is associated with suicidality, although it is not an expression of suicidal intent. NSSI behaviours range from minor skin scratching to injury requiring medical attention, and in extreme cases, death. NSSI is understood as an effort to modulate emotion in times of crisis and distress. Causal models have been developed for self-h

This paper aims at mapping the challenges of the state of the art of conventional and powder metallurgy (PM) gear manufacture in order to provide knowledge on what parameters need to be considered when modelling the cost and benefit analysis relating to sustainability. An exploratory case study was designed where a series of interviews aimed to identify the complete set of operational steps for bo