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Proton-detected NMR diffusion and P-31 NMR chemical shifts/bandwidths measurements were used to investigate a series of liposomal formulations where size and PEGylation extent need to be controlled for ultrasound mediated drug release. The width of the P-31 line is sensitive to aggregate size and shape and self-diffusion H-1 NMR conveys information about diffusional motion, size, and PEGylation ex
The breakup of 12Be into 6He+6He and 4He+8He has been studied using a 378 MeV 12Be beam inelastically excited by 12C and (CH2)n targets. The measurements indicate that breakup occurs from rotational states in the 10 to 25 MeV excitation energy interval, with spins in the range of 4ħ to 8ħ. The inferred moment of inertia is consistent with the cluster decay of an exotic molecular structure in 12Be,
The mechanical properties of polystyrene/polyamide-6 (50/50 wt/wt) blends were improved by additions of small amounts of poly(styrene-g-ethylene oxide) (SEO) during compounding by extrusion. Tensile testing of injection-molded samples revealed that the blends developed a yield point after addition of 1 wt % SEO. The elongation at break increased by almost a factor of 6, and the impact strength inc
We analysed five data sets of night directions of migrating arctic waders ill relation to,winds, recorded by tracking radar and optical range finder, in order to find out if these birds compensate for wind drift, or allow themselves to be drifted by winds. Our purpose was to investigate whether arctic waders use adaptive wind drift strategies or not. The data sets were collected in Siberia (two se
Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer
Objective. To investigate the prevalence of current and chronic pain and their relationship to pain intensity, sex, age, income, employment status, citizenship, marital status, urban residence, occupational activity, and healthcare-seeking based on a representative sample from a Swedish county. Methods. A cross-sectional survey using a postal questionnaire was sent to a representative sample (n =
Previous studies on patients with breast cancer, who received postsurgical irradiation, displayed a markedly suppressed inflammatory response in the lung of smoking patients compared to nonsmokers. The aim of the present study was to investigate further the effect of exposure to tobacco smoke on the development of irradiation-induced pneumonitis in the rat. Four groups of animals were used: contro
The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe
Web sites are exposed to high rates of incoming requests. Since web sites are sensitive to overload, admission control mechanisms are often implemented. The purpose of such a mechanism is to prevent requests from entering the web server during high loads. This paper presents how admission control mechanisms can be designed and implemented with a combination of queueing theory and control theory. S
Chromosome segment 12q13 -> q15 recombines with many different chromosome bands in lipomas and at least ten recurrent translocations have been identified. The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints. Fusion genes between HMGA2 (12q14 -> q15) and LPP (3q27 -> q28), LHFP (13q12) and CMKOR1 (2q37) have been reported. In the present stu
In neonatal retinal explants cultured long-term green cones are missing. Recently it was reported that thyroid hormone beta2 receptors (TR-beta2) are essential for these green cones to differentiate. Therefore transcript level of these receptors was investigated in our mouse retinal explants. However, thyroid receptors function as heterodimers with retinoid receptors (RR); so the fate of selected
Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni
Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determine PIN1 polarization and how this gives rise to regular patterns of auxin concen
