Background: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. Results: Hippocampal slices from 6 days old mice showed

FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational entropy upon ligand binding. Here we report backbone and methyl-axis order parameters of the apo and FK506-bound forms of FKBP12, based on 15N and 2H NMR relaxa

The problem of low-rank approximation with convex constraints, which appears in data analysis, system identification, model order reduction, low-order controller design and low-complexity modelling is considered. Given a matrix, the objective is to find a low-rank approximation that meets rank and convex constraints, while minimizing the distance to the matrix in the squared Frobenius norm. In man

A transmission polarizer for producing elliptically polarized soft X-ray radiation from linearly polarized light is presented. The setup is intended for use at synchrotron and free-electron laser beamlines that do not directly offer circularly polarized light for, e.g., X-ray magnetic circular dichroism (XMCD) measurements or holographic imaging. Here, we investigate the degree of ellipticity upon

There is scientific evidence of accelerated sea level rise and saline intrusion. Some impacts, such as stratification and estuarine circulation, are subtle; others are dramatic including shifts in salt-sensitive habitats and limited water availability of suitable quality for industrial and municipal uses. These results have become a remarkable reality resulting in a set of integrated surface water

A new model; WORLD6 was developed. WORLD6 differs from the earlier system dynamics world models in several aspects. Several modules link the economy, materials, metals, energy, population and politics in a dynamic system. The present version is a result of a dismantling of the World3 model (Meadows et al., 1972, 1992, 2004) with an extension and substitution of its resource module and economy modu

The global supply of cobalt was simulated by combining 3 different system dynamics models; BRONZE, PGM and STEEL. The present use of cobalt shows a low degree of recycling and systemic losses are significant. The reserves of cobalt are not very large (20-25 million ton extractable) as compared to metals like copper, zinc or iron, and after 2170 cobalt will have run out under a business-as-usual sc

The complement system is an ancient part of the innate immune system important for both tissue homeostasis and host defense. However, bacteria like Staphylococcus aureus (SA) possess elaborative mechanisms for evading both the complement system and other parts of the immune system. One of these evasive mechanisms-important in causing chronic and therapy resistant infections-is the intracellular pe

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master- switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical- generating subunit. The ATP-co

Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo

Purpose: The purpose of this paper is to explore how the notion of “relevance” is produced, distributed and consumed in the field of management research by applying a critical discourse analysis (CDA) as a theoretical lens. A CDA perspective offers a way to scrutinize the power relations that emerge with journal rankings and how these influence how the relevance discourse develops. Design/methodol

We investigated the pragmatic effects of gesture-speech lag by asking participants to reconstruct formations of geometric shapes based on instructional films in four conditions: sync, video or audio lag (±1,500 ms), audio only. All three video groups rated the task as less difficult compared to the audio-only group and performed better. The scores were slightly lower when sound preceded gestures (

The Sendai Framework for Disaster Risk Reduction highlights the importance of all-hazard and multi-stakeholder approaches. This requires exchange and integration of risk information across sectorial and administrative borders. This paper focuses on challenges and prerequisites for aggregating risk information from multiple stakeholders in disaster risk management systems. Aggregation is here under

Animal models of neurological deficits are essential to assess new therapeutic options and reduce treatment complications. Over the last decades, several rodent models of Parkinson's disease have been developed, and have now become the first-line experimental tool for therapeutic screening purposes. Which model is the most predictive for identifying the efficacy of symptomatic or disease-modifying

Avhandlingen Naturliga medborgare undersöker hur frilfutsliv och lägerverksamhet använts som metoder för medborgarfostran i scoutrörelsen och Unga Örnar under perioden 1925–1960. Frågorna som undersökts innefattar hur organisationerna artikulerade ideal om medborgarskap, hur barn och ungdomar skulle fostras till goda medborgare samt mer specifikt hur natur och friluftsliv skulle bidra till att förThe aim of this thesis has been to examine outdoor activities and camping, framed within the Scandinavian notion of friluftsliv, as methods for promoting citizenship in two Swedish youth organisations: the Scout movement and Unga Örnar (“Young Eagles”). What knowledge and abilities characterised ideal citizenship; how was instruction in citzenship for children conducted and more specifically, how

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-offlight mass spectrometry (MALDI-TOF-MS) that enables capture and identification of prostate-specific antigen (PSA) in samples. An anti-PSA antibody (H117) was mixed with a sol-gel, and the mixture was spotted onto a porous silicon (pSi) surface without additional surface modifica

In the era of the Internet of Things and social media; communities, governments, and corporations are increasingly eager to exploit new technological innovations in order to track and keep up to date with important new events. Examples of such events include the news, health related incidents, and other major occurrences such as earthquakes and landslides. This area of research commonly referred t