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Hypoxia induces radioresistance, epithelial?mesenchymal transition, cancer stem cell?like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma

Hypoxia has been linked with increased resistance to treatment in various solid tumors, including head and neck squamous cell carcinoma (HNSCC). The aim of the present study was to identify genes involved in hypoxia?mediated responses to radiotherapy in HNSCC. A total of three HNSCC cell lines with an epithelial phenotype were selected for this study and cultured under normoxic (21% O2) or hypoxic

Children's voices on their participation and best interests during a hospital stay in Australia

Purpose: To explore school-aged children's experiences about their best interests and participation in care during a hospital admission. Design and methods: A descriptive qualitative design involving in-depth, iterative inductive review of child responses to generate key words that led to identification of categories and themes. The study was guided by the United Nations Convention on the Rights o

Natural language analyzed with AI-based transformers predict traditional subjective well-being measures approaching the theoretical upper limits in accuracy

We show that using a recent break-through in artificial intelligence -transformers-, psychological assessments from text-responses can approach theoretical upper limits in accuracy, converging with standard psychological rating scales. Text-responses use people's primary form of communication -natural language- and have been suggested as a more ecologically-valid response format than closed-ended

Super-Size Me: An Unsuccessful Preregistered Replication of the Effect of Product Size on Status Signaling

Dubois, Rucker, and Galinsky (2012, Experiment 1) found that consumers view larger-size options as a signal of higher status. We conducted a close replication of this finding (N = 415), and observed a nonsignificant effect in the opposite direction (small vs. large product size: doriginal = 1.49, 95%CI [1.09, 1.89], dreplication = 0.09 95%CI [-0.15, 0.33]; medium vs. large: doriginal = 0.89 95%CI

Complex expressions of power. Forms of inequality in violent intimate relationships in Sweden

Despite highly rated country-level gender equality, survey-reported experiences of intimate partner violence against women (IPVAW) are common in Sweden, as in neighbouring Nordic countries. This apparently contradictory situation has been referred to as a Nordic Paradox. Among potential partial explanations for this supposed paradox, the complex or multidimensional nature of gender in/equality has

Alternative facts or women’s empowerment? Swedish women’s claims about the health risks of copper IUD use

The internet has radically transformed the way that people seek and share information and, as a consequence, their relationship to established epistemic authorities. It has been stated that ‘the contestation of expertise is perhaps nowhere more pronounced’ than in the field of health (Vuolanto et al., 2020: 508). Health-related information on the internet stems from a variety of actors and sometim

Similarities and differences between China and Sweden regarding the core features of palliative care for people aged 60 or older : a systematic scoping review

BACKGROUND: Despite the increasing longevity of the world's population, with an unprecedented rise in the number of people who need palliative care (PC), there has been sparse research regarding palliative care for older people, especially when it comes to comparison of PC between healthcare systems and cultures. The aim of this systematic scoping review was to identify the characteristics of the

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and in-tegrated into the genome of human cells. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro.

Motherhood: A Resource for Social Resilience and Holistic Wellbeing

Background: The desire to be a mother is much more than a reproductive instinct in pro-baby (pro-natal) society. Motherhood is a complex phenomenon that encompasses psychological, social, and cultural aspects of a woman's holisticwell-being. A woman's socio-cultural visibility is enhanced through motherhood, which also strengthens her psychological status, enriches her spiritual experience, and en

Strategies to increase the rate of vaginal deliveries after cesarean without negative impact on outcomes

Objective: To compare the rate of vaginal birth after cesarean section (VBAC), including the maternal and perinatal outcomes, in two historical cohorts before and after the implementation of specific changes in the clinical practice. Design: A retrospective cohort study. Setting: Skåne University Hospital in Malmö, Sweden. Participants: including all women with one previous cesarean section (CS),

Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells

Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim

Implementation structures at work. Exploring implementation and de-implementation attempts regarding Housing First and Individual Placement and Support

Research shows that resistance to change might occur in organisations that implement new evidence-based practices (EBP). Formal and informal structures may work to retain traditional interventions, potentially counteracting the implementation process. Little is known about the de-implementation of traditional practices to leave room for and enhance the implementation of EBPs. This study uses imple

Navigating conflicting desires: Parenting practices and the meaning of educational labor in urban East Asia

South Korea and Singapore have established a reputation as top performers in international student assessment tests and rankings, which is usually understood to be the result of competitive education systems and a distinct parenting culture. They also share a large private tuition industry, fueled by parents’ anxiety over their children’s academic achievements and future. In an attempt to contest South Korea and Singapore have established a reputation as top performers in international student assessment tests and rankings, which is usually understood to be the result of competitive education systems and a distinct parenting culture. They also share a large private tuition industry, fueled by parents’ anxiety over their children’s academic achievements and future. In an attempt to contest

Doing responsible parenthood: Parental involvement in young children’s education in urban South Korea and Singapore

Questions around parental involvement in education, not only in in East Asia but also in a global context, are significant, given the increased concern in ‘population quality’ and the ever-growing education market. South Korea and Singapore are widely recognized for their competitive education systems and for consistently topping international student assessment tests. They also share a ballooningQuestions around parental involvement in education, not only in in East Asia but also in a global context, are significant, given the increased concern in ‘population quality’ and the ever-growing education market. South Korea and Singapore are widely recognized for their competitive education systems and for consistently topping international student assessment tests. They also share a ballooning

Ambiguous aspirations: Parenting strategies around young children’s education in urban South Korea and Singapore

South Korea and Singapore are widely recognized for their competitive education systems and for consistently topping international student assessment tests. They also share a ballooning private tuition industry, fueled by parents’ anxiety over their children’s academic achievements. This paper is based on a comparative ethnographic study on parenting strategies around young children’s (aged 4-12)

Tiger Mums and Home Schoolers: Trajectories of Parents’ Educational Work in Contemporary Singapore

The size, structure and ‘quality’ of the population are issues of concern in contemporary East Asia, as the region is becoming enmeshed with the global economy, and competitiveness increasingly centers on ‘a fitting’ human capital. While Singapore is located in Southeast Asia geographically speaking, it is culturally linked to East Asia in terms of its heritage of Confucianism and the Chinese lang

How and Why Freight Trains Deviate from the Timetable : Evidence from Sweden

European infrastructure managers (IMs) create annual timetables for trains that will run during a year. Freight trains in Sweden often deviate from this by being added, cancelled, delayed or early, resulting in increased costs for IMs and railway undertakings (RUs). We investigate the frequency of and causes for these deviations, using one year of operational data for 48,000 trains, and 15 stakeho