Impaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a transgenic mouse model of Parkinson's disease expressing human wild-type α-synuclein under the control of the

En krönika över flera generationer av missionärer från samma släkt och från Svenska kyrkan, som från missionsfältet i Indien skriver till sina barn, som togs om hand av släktingar i Sverige. Tidsperioden sträcker sig från mitten av 1800-talet till mitten av 1900-talet.

Ectoedemia argyropeza (Zeller, 1839) possesses a compound eye that exhibits features of both apposition and superposition type eyes. Like apposition eyes, the eye of E. argyropeza lacks a clear-zone, which in superposition eyes separates the distal dioptric from the proximal light-perceiving structures. On the other hand, a tracheal layer around the proximal ends of the rhabdom as well as a well-d

The concept of a digital cavity is presented. The functionality of a tunable radio-frequency/microwave cavity with unrestricted Q-factor is implemented. The theoretical aspects of the cavity and its potential applications in high resolution spectroscopy and synchronization of clocks together with examples in signal processing and data acquisition are discussed.

A central tenet of signal transduction in eukaryotic cells is that extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream responses. This ''protein-centric" view is increasingly challenged by evidence for the involvement of specialized membrane domains in signal transduction. Here, we propose that membrane perturbation may serve as an alternative mechanism to

To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).

The PHENIX experiment at RHIC has measured and ω meson production in p+p, d+Au and Au+Au collisions for GeV at mid-rapidity. Systematic measurements of light vector mesons for several decay channels provide information about properties of the strongly interacting matter produced in relativistic heavy-ion collisions. We present transverse momentum spectra and nuclear modification factors for and ω

Clays are of paramount importance for soil stability, but also in applications ranging from oil recovery to composites and hydrogels. Generically, clays are divided into two subclasses: macroscopically swelling, ‘active’ clays that have the capacity for taking up large amounts of water to form stable gels, and ‘passive’ or non-swelling clays; the former stabilize soils whereas the latter are known

Popular Abstract in Swedish Mesenkymala stamceller (MSC) kan isoleras från en rad olika vävnader i kroppen, bland annat från benmärg. De kan differentiera till ben, brosk, fett- och bindvävnad men deras exakt roll i kroppen är inte väl känd. Den senaste forskningen tyder dock på att en av deras huvuduppgifter är att stödja blodbildningen som sker av blod- eller hematopoetiska stamceller. Man Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. MSC cultures however, are heterogeneous and, while critical for clinical applications, their exact composition is not known. W

This paper analyzes the role of initialization when testing for a unit root in panel data, an issue that has received surprisingly little attention in the literature. In fact, most studies assume that the initial value is either zero or bounded. As a response to this, the current paper considers a model in which the initialization is in the past, which is shown to have several distinctive features

We demonstrate high-resolution tunable diode laser absorption spectroscopy (TDLAS) of water vapor confined in nanoporous alumina. Strong multiple light scattering results in long photon pathlengths (1 m through a 6 mm sample). We report on strong line broadening due to frequent wall collisions (gas-surface interactions). For the water vapor line at 935.685 nm, the HWHM of confined molecules are ab

Background 3-Hydroxypropionic acid (3HP) and acrylic acid (AA) are industrially important platform- and secondary chemical, respectively. Their production from renewable resources by environment-friendly processes is desirable. In the present study, both chemicals were almost quantitatively produced from biodiesel-derived glycerol by an integrated process involving microbial and chemical catalysis

A new genus, Catenarina (Teloschistaceae, Ascomycota), with three species is described from the Southern Hemisphere, supported by molecular data. All species contain the secondary metabolite 7-chlorocatenarin, previously unknown in lichens. Catenarinadesolata is a non-littoral, lichenicolous species found on volcanic and soft sedimentary rock at 190-300 m in and near steppes in southernmost Chile

Windows in a package is a common way to promote the product. The possibility to predict the collapse load for these types of cartonboard packages is considered. It is shown that reliable estimates of the collapse loads can be obtained by a very simple approach. This approach is a straightforward generalization of the proposal by Ristinmaa et al. (2012): for a side that contains a window, one simpl

Critical evaluation of the World Missionary Conference, Edinburgh 1910, from the perspective of later 20th century developments in Christian mission and ecumenism, with special attention to the global South and postcolonial analysis.