Tomato thymidine kinase 1 (ToTK1) is a deoxyribonucleoside kinase (dNK) that has been subject to study because of its potential to phosphorylate the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd). The combination of ToTK1 and AZT has been tested in two animal studies for its efficiency and use in suicide gene therapy fo

Background Existing reports on quality-of-life (QoL) after bile duct injury (BDI) are conflicting. Methods Case-control study were QoL assessment was performed using SF-36 (36-item short Form health survey). Patients with BDI were compared to a matched control group (1:2) subject to cholecystectomy. Results In total 168 BDIs (0.3%) were eligible for participation and 64% returned SF-36. Median fol

Background: Randomized trials have shown that neoadjuvant treatment improves survival in the curative treatment of oesophageal and gastro-oesophageal junction cancer. Results from population-based observational studies are, however, sparse and ambiguous. Methods: This prospective population-based cohort study included all patients who had oesophagectomy for cancer in Sweden, excluding clinical T1

Spectroscopic studies of the reaction of [Os-3(CO)(11)MeCN)] with para-thiocresol to form [Os-3(mu-H)(CO)(10)(mu-SC6H4Me-p)] indicate that the reaction proceeds via a two-step consecutive process involving the intermediate [Os-3(CO)(11)-(MeC6H4SH-p)], in which there is an agostic Os-H-S interaction.

Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration. To further outline the involvement of this channel in this process, we here explore modulation of Transient Receptor Potential Vanilloid 4 (TRPV4) activity on neuronal health and glial activation in an in vitro model of retinal degeneration. For this

The Sustainable Development Goals (SDGs) require nations to ensure adequate water supply for all. For Kazakhstan, this means that rural areas will need much stronger attention as they have been rather neglected in efforts to comply with the Millennium Development Goals (MDGs). This study aims to establish a baseline data concerning the current situation in villages that will need interventions acc

Finite element modelling (FEM) is used to show that the addition of Au contacts to a single horizontal InAs/InP heterostructure nanowire substantially alters the nanowire's optical properties in comparison to the uncontacted case. It is found that the addition of contacts can increase absorption efficiency, decrease scattering efficiency and shift the location of absorption within the nanowire. Lo

Surprisingly few studies connect the chemical, mechanical, and hydrological evolution of rock as it weathers to saprolite and soil. We assess this coevolution in granodiorite from Monterey Peninsula, California, by measuring changes in bulk chemistry, mineralogy, volumetric strain, the oxidation state of Fe in biotite crystals, tensile strength, abrasion rate, connected porosity, and hydraulic con

The degradation of natural resources as a result of consumption to support the economic growth of humans society represents one of the greatest sustainability challenges. In order to allow economic growth to continue in a sustainable way, it has to be decoupled from the consumption and destruction of natural resources. This thesis focuses on an innovative manufacturing technology called additive m

This article analyzes producer-consumer relations in social media marketing in the Swedish dairy industry. The article discusses how ideas of interspecies intimacy are publicly performed in an interactive process between the dairy industry producers and social media users. Two examples from the Swedish dairy industry were chosen for analysis: one Instagram account and one Facebook account. The ana

The invention is directed to a method of increasing the chemical and/or thermal stability of PHA in biomass where the biomass is contained within mixed liquor, and wherein the mixed liquor is treated by a combination of removing water from the mixed liquor and pH adjustment of the mixed liquor or maintenance of the pH of the mixed liquor within a selected pH range, and wherein the method includes

Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in nanofluidic channels, which provides detailed information about the plasmids present in a bacterial isolate. In a single experiment, we obtain the number of different plasmids in the sample, the size of each plasmid, an optica

OBJECTIVE: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of horm