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BACKGROUND: Atherosclerosis, the major cause of mortality and invalidity in industrialized countries, is a multifactorial disease associated with high plasma cholesterol levels and inflammation in the vessel wall. Many different genes have previously been demonstrated in atherosclerosis, although limited numbers of genes are dealt with in each study. In general, data on dynamic gene expression dur
The ability to identify craft specialization in the archaeological record has wider ramifications for the study of prehistoric society, since it is apparent that there is a certain relationship between the organization of craft specialization and social complexity. The aim of the project is to determine if craft specialization was present in pre-Iron Age southern Scandinavian society and to descri
Relations between indices of mineral metabolism and blood pressure were examined in 182 subjects, comprising 58 patients with essential hypertension (EHT) and 124 healthy subjects attending a general health survey. Multivariate techniques of statistical analysis were employed to test the hypothesis of different relationships between blood pressure and calcium metabolism within the subpopulations a
There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present study, we show that islets intended for islet transplantation produce tissue factor in both the transmembrane and
The intracellular signal cascade transducing muscarinic-receptor-stimulation to gene expression was investigated in human neuroblastoma SH-SY5Y cells. Naive and ethanol-exposed SH-SU5Y cells were stimulated with carbachol (CCh) and inositol 1,4-5-trisphosphate (IP3), 1,2-diacylglycerol (DAG), and c-fos mRNA levels were analyzed using a radioreceptor assay (IP3) thin-layer chromatography (DAG) and
The adhesion receptor CD-31 is expressed on neutrophils and endothelial cells and participates in transendothelial migration of neutrophils. Although necessary, information on CD-31-induced signaling and its influence on the shape-forming actin network is scarce. Here, we found that antibody engagement of CD-31 on suspended neutrophils triggered a prompt intracellular Ca(2+) signal, providing the
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in
Popular Abstract in Swedish Blekinge tillhörde före freden i Roskilde 1658 Danmark. De östdanska provinserna erövrades av svenskarna och integrerades i det svenska riket. Övergångsproblematiken har i äldre forskning ofta diskuterats och analyserats med begrepp hämtade från en senare tids nationella föreställningar. Men var de motsättningar och konflikter som utvecklades i Blekinge efter övergångenThe object of this thesis is to examine the incorporation of the former Danish province of Blekinge into Sweden after the Treaty of Roskilde in 1658. This question has been analysed before but such studies have usually been coloured by the use of national ideas and notions born of a later age than the period under examination. This thesis analyses the so-called Transition Problem using theoretical
A parallel procedure based on a single-program, multiple-data (SPMD) algorithm is presented for parallel computing of turbulent combustion and flame spread in fires. The computation is based on modeling of radiative turbulent reacting flow and pyrolysis of solid fuel. With angular domain decomposition applied to the parallel computing of radiation and spatial domain decomposition to the computatio
Cellobiose dehydrogenase (CDH) is a monomeric protein consisting of two subdomains: a larger flavin-associated domain (DHcdh) and a smaller heme-binding domain (CYTcdh), connected via a protease cleavable linker region. In this study, the inter-domain electron transfer, using the CDH from the ascomycete fungus Myriococcum thermophilum and thiol (SAM) modified gold electrodes, was investigated with
We find that the nature and origin of the proposed "dialogical cognitive representations" in the target article is not sufficiently clear. Our proposal is that (triadic) bodily mimesis and in particular mimetic schemas-prelinguistic representational, intersubjective structures, emerging through imitation but subsequently interiorized-can provide the necessary link between private sensory-motor exp
Background: Current models of group and team development generally favour a linear progressive developmental pattern (Tuckman-Wheelan), taking for granted that all groups move from relative irrationality and inefficency to rationality and efficiency through learning or maturation in sequential stages. Aims: (i) To question the generality of the linear progressive models of group development, (ii)
The dynamics of the excited states of the carotenoid peridinin in polar solvents were studied using femtosecond transient absorption spectroscopy in the spectral range of 500-1900 nm. A broadening of the absorption spectrum in polar solvents is caused by a distribution of conformers having different ground-state properties. In addition, the dependence of the peridinin lifetime on the excitation wa
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