The biochemical mechanisms underlying glucose-stimulated insulin secretion from pancreatic beta-cells are not completely understood. To identify metabolic disturbances in beta-cells that impair glucose-stimulated insulin secretion, we compared two INS-1-derived clonal beta-cell lines, which are glucose-responsive (832/13) or glucose-unresponsive (832/2). We found that despite a marked impairment o

Cancer patients diagnosed with type 2 diabetes mellitus (T2DM) are at an increased risk of death due to cancer. However, whether T2DM comorbidity increases other causes of death in cancer patients is the novel theme of this study. Patients with T2DM were identified from the nationwide Swedish Hospital Discharge Register and linked with patients with cancer recorded from the Swedish Cancer Registry

BACKGROUND:: Platelets not only control thrombosis and haemostasis but may also regulate inflammatory processes. Acute pancreatitis (AP) is characterized by changes in both coagulation and proinflammatory activities. The role of platelets in AP is not yet known. METHODS:: AP was induced in C57BL/6 mice by repeated caerulein administration (50 µg/kg intraperitoneally). Mice received a platelet-depl

The Lundby Study is a prospective cohort study, which has followed a Swedish unselected community sample between 1 July 1947 and 1 July 1997. The aim was to study the risks of mental morbidity and different DSM-IV disorders in subjects with intellectual disability (ID) in the Lundby cohort between 1 July 1947 to 30 June 1997. The diagnosis of ID was re-evaluated according to DSM-IV in subjects who

Abstract is not available

Artikeln handlar om bokhandelns situation och orsakerna bakom dess svårigheter och den är delvis en kommentar på en artikel av Per Svensson.

Kulturartikel om rysaren och spökfilmens återkomst i skräckgenren efter decennier av bloddrypande och våldsam slasherfilmer.

Kulturartikel om Alfred Histchcocks Psycho och filmens betydelse för att förändra skräckfilmsgenren.

Granulocyte chemotactic protein 2 (GCP-2)/CXCL6 is a CXC chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. Through binding and activation of its receptors (CXCR1 and CXCR2), it exerts neutrophil-activating and angiogenic activities. Here we show that GCP-2/CXCL6 itself is antibacterial. Antibacterial activity against gram-positive and gram-negative pathog

Kraven på mera avancerade verifieringsmetoder har ökat i takt med att det traditionella sättet att projektera en byggnads brandskydd har förändrats, samt att vi idag är mer medvetna om vilka riskerna är, t ex att tillförlitlighet i tekniska skyddssystem måste beaktas. Detta är nödvändigt för att säkerställa att samhällets krav på brandsäkerhet efterlevs och uppfylls.