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Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer (HYPO-RT-PC) : patient-reported quality-of-life outcomes of a randomised, controlled, non-inferiority, phase 3 trial

Background: The HYPO-RT-PC trial compared conventionally fractionated radiotherapy with ultra-hypofractionated radiotherapy in patients with localised prostate cancer. Ultra-hypofractionation was non-inferior to conventional fractionation regarding 5-year failure-free survival and toxicity. We aimed to assess whether patient-reported quality of life (QOL) differs between conventional fractionation

Den praktiska teologin som professionsteori

Artikeln påminner svensk praktisk teologi om dess historiskt givna identitet samt visar att denna identitet härleds ur ett bestämt encyklopediskt sammanhang. Utgångspunkten för den encyklopediska bestämningen är att akademisk teologi är en i Schleiermachers mening positiv vetenskap, vars uppgift är att främja kyrka och kristendom. I denna positiva vetenskap har den praktiska teologin rollen av proThe purpose of this article is to remind Practical Theology in Sweden of its historically given identity and to show that this identity derives from a welldefined encyclopedic context. The point of departure is that theology is a positive science, in the sense used by Friedrich Schleiermacher: a science directed towards a specific goal, which in theology's case is the wellinformed government of th

RIFM fragrance ingredient safety assessment, glyceryl monooleate, CAS Registry Number 111-03-5

The existing information supports the use of this material as described in this safety assessment. Glyceryl monooleate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that glyceryl monooleate is not genotoxic. Data on glyceryl monooleate provide a cal

Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes

Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiogram

Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers

Background & Aims: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations. Methods: We identified 3645 patients with a homozygous p.C282Y (62%) or a compound heterozygous p.C282Y/p.H63D (3

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects

The development of tau-PET allows paired helical filament tau pathology to be visualized in vivo. Increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of Alzheimer's disease. However, the factors modifying the rate of tau accumulation over time in Alzheimer's disease are still largely unknown. Large-scale longi

Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease

Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the Alzheimer's disease continuum. The aim of this study was to investigate how plasma NfL relates to amyloid and tau PET and MRI measures of brain atrophy in participants with and without cog

Progymnasmata : Afthonios' retoriska övningar översatta och kommenterade av Anders Eriksson

Översättning av antik källtext, Afthonios progymnasmata från klassisk grekiska till svenska, 32 sidor. Inledning med historisk kontext, tidigare översättningar på andra språk, översättningsprinciper och forskningsöversikt, 40 sidor. Kommentar av översättningen, förklaring av retorisk teori, grekisk mytologi och historiska bakgrund, 120 sidor. Första upplagan från 2002 slutsåld. Ny andra upplaga i

"What's the problem?"-Toward a framework for collective problem representation in emergency response management

Responding to today's often transboundary emergencies, frequently characterized by unclear root causes and indistinct responsibilities as well as multiple actors, will require that responding actors come together to meet societal needs and solve problems arising in relation to those needs. In collective problem solving, representing the problem is crucial, especially in emergency situations, where

Apocalyptic argumentation : Trump and ISIS

Vi lever i en apokalyptisk tid. Apokalyptisk argumentation till stor del outforskad. Artikeln presenterar en analysmodell i tre steg: upplevd ondska, tidens tecken och tillförlitlig auktoritet, inspirerad av Stephen O'Leary. Artikeln innehåller två analysexempel: USA:s förre president Donald Trump och den Islamiska staten. Båda bygger sin argumentation på en apokalyptisk världsbild.Our time is an apocalyptic time, but the argumentation in this apocalyptic time has hardly been studied by scholars of argumentation. This article shows how both Donald Trump and the jihadist warriors of ISIS appeal to an apocalyptic worldview in their argumentation. The three topos of evil, time and authority from Stephen O’Leary’s Arguing the Apocalypse are used in the analysis. Both Trump suppo

Differential expression of cerebrospinal fluid neuroinflammatory mediators depending on osteoarthritis pain phenotype

ABSTRACT: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplast

A comparative study between the two patch-test systems Finn chambers and Finn chambers AQUA

Background: Finn Chambers AQUA (FCA) is a development of the Finn Chambers (FC) test system in which the test chambers are mounted on a moisture-resistant adhesive patch. FCA has pre-fixed filter papers. Because the use of FCA does not require any extra taping or use of separate filter papers, a change from FC to FCA chambers may be beneficial for both patients and patch-test technicians. Objectiv