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Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion.

CD55 is a glycosylphosphatidylinositol-anchored protein, which inhibits complement activation by acting on the complement C3 convertases. CD55 is widely localized in the cholesterol rich regions of the cell plasma membrane termed membrane rafts. CD55 is attached to these specialized regions via a GPI link on the outer leaflet of the plasma membrane. Membrane rafts anchor many important signaling p

Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease.

In Huntington's disease (HD), cognitive symptoms and cellular dysfunction precede the onset of classical motor symptoms and neuronal death in the striatum and cortex by almost a decade. This suggests that the early cognitive deficits may be due to a cellular dysfunction rather than being a consequence of neuronal loss. Abnormalities in dendritic spines are described in HD patients and in HD animal

A lower crustal mafic source for the ca. 2550 Ma Qorqut Granite Complex in southern West Greenland

The late Neoarchaean Qorqut Granite Complex is the youngest large igneous intrusion in the Nuuk region in southern West Greenland, where basement is primarily of Eoarchaean and Mesoarchaean age with a tonalite-trondhjemite-granodiorite (TTG) composition. The Qorqut granite is generally undeformed and it intruded during a prolonged period, starting at ca. 2730 Ma, characterised by crustal reworking

A 2-year follow-up study of people with severe mental illness involved in psychosocial rehabilitation

Backgrounds. A focus on psychiatric rehabilitation in order to support recovery among persons with severe mental illness (SMI) has been given great attention in research and mental health policy, but less impact on clinical practice. Despite the potential impact of psychiatric rehabilitation on health and wellbeing, there is a lack of research regarding the model called the Psychiatric Rehabilitat

Revision of the European Delia pruinosa species group (Diptera: Anthomyiidae) feeding as larvae in seed capsules of Silene L. (Caryophyllaceae)

The European taxon Delia pruinosa (Zetterstedt) currently treated as one species is shown to represent a complex of several closely related species all characterized by the short antennnae, enlarged proboscis with strong, black prestomal teeth and a weak tibial setation. Biologically, all members of this Delia pruinosa species group may share the larval habit of living in seed capsules of various

Aspiration Learning in Coordination Games

We consider the problem of distributed convergence to efficient outcomes in coordination games through dynamics based on aspiration learning. Our first contribution is the characterization of the asymptotic behavior of the induced Markov chain of the iterated process in terms of an equivalent finite-state Markov chain. We then characterize explicitly the behavior of the proposed aspiration learnin

12-month outcome and predictors of recurrence in psychiatric treatment of depression – a retrospective study.

Many individuals treated for depression suffer relapse or recurrence after treatment. Known risk factors include number of previous depressive episodes and residual symptoms after treatment. Both relapse/recurrence rates and predictors of relapse/recurrence, however, may differ between various settings. To perform a naturalistic evaluation of the sustained effectiveness of treatment for adult clin

New insights into the dynamics of vacuum impregnation of plant tissues and its metabolic consequences.

The complex and highly interconnected intercellular air spaces of plant tissues occupied by gas or native liquid has offered the possibility for impregnation with a wide range of compounds. In food processing, the development of vacuum impregnation has allowed a controlled way to introduce these compounds to the tissue structure aiming at modifying structural, nutritional, and/or functional proper

The interactive effect of an AM fungus and an organic amendment with regard to improving inoculum potential and the growth and nutrition of Trifolium repens in Cd-contaminated soils

Aspergillus niger-treated dry olive cake (DryOC) can be used as a soil organic amendment and the aim of this work was to study the effectiveness of this amendment and a Cd-adapted arbuscular mycorrhizal (AM) fungus in improving Trifolium repens growth and nutrition in Cd-contaminated soil. In a compartmentalized growth system, consisting of a root compartment (RC) and two hyphal compartments (HCs)

No longer a waltz between red wine and mint tea : the portrayal of the children of immigrants in French newspapers (2003–2013)

Despite the egalitarianism that informs French civic culture, the socio-economic marginalization of citizens of non-European origin, mostly from North African countries, provide empirical evidence that challenges the French Republican ideal of integration. Such marginalization needs to be reconciled especially within the cultural realm. In this article, we look at French newspapers’ coverage of th

Is the PANSS cognitive scale measuring cognition?

Objective: To investigate the association between the Positive and Negative Syndrome Scale (PANSS) cognitive factors and cognition assessed by neuropsychological tests. Method: Ninety patients with a psychotic illness, the majority having a schizophrenia diagnosis, were assessed with PANSS ratings and tested by a comprehensive computerized neuropsychological test battery, EuCog. Results: Test perf

Monitoring Economic Development from Space: Using Nighttime Light and Land Cover Data to Measure Economic Growth

This study demonstrates estimations of economic activities on global, national, and subnational levels using remote sensing data, with a focus on developing economies. It extends a recent statistical framework which uses nighttime lights to estimate official income growth by accounting for agriculture and forestry which emit less or no additional observable nighttime light. The study argues that n

Visualisation of the rectoanal inhibitory reflex with a modified contrast enema in children with suspected Hirschsprung disease.

BACKGROUND: Patients with Hirschsprung disease lack the normal rectoanal inhibitory reflex, which can be studied with anorectal manometry or US. OBJECTIVE: To see whether the rectoanal inhibitory reflex could be visualised with a modified contrast enema, thereby increasing the diagnostic accuracy of the contrast enema and reducing the number of rectal biopsies. MATERIALS AND METHODS: Fifty-nine bo

Overexpression of Aurora-A promotes laryngeal cancer progression by enhancing invasive ability and chromosomal instability

The purpose of the study was to investigate the expression of Aurora-A in human laryngeal squamous cell carcinoma (LSCC) and to explore the effects of Aurora-A silencing on invasion and chromosomal instability in laryngeal cancer HEp-2 cells. The expression of Aurora-A mRNA and protein were studied using reverse transcription-PCR and Western blot in LSCC tissues and corresponding normal epithelium

A comparative study of nursing staff, care recipients and their relatives’ perceptions of quality of older people care

Background. Comparisons of different stakeholders' ratings of the quality of older people care can help to drive quality improvement. Aim. The aim was to compare staff, older care recipients' and their relatives' quality of care ratings. Design. Cross-sectional questionnaire surveys in 2003 and 2004, using a repeated measures design on an organizational level. Methods. Nursing staff, care recip

Quality of life, physical function and MRI T2*in elderly low-risk MDS patients treated to a haemoglobin level of >= 120 g/L with darbepoetin alfa +/- filgrastim or erythrocyte transfusions

Objective: Anaemia in low-risk MDS is associated with reduced quality of life (QoL). Response to treatment with erythropoietin (EPO) + G-CSF is associated with improved QoL, but whether transfusion therapy with higher haemoglobin (Hb) target levels has similar effects is unknown. The objective for this prospective phase II Nordic multicentre trial was to assess QoL, response rate and physical func

Banning homosexual propaganda. Belonging and visibility in contemporary Russian media

This article investigates Russian mainstream media’s coverage of the 2013 legislation banning “propaganda for non-traditional sexuality”. Inspired by theories on belonging, media and visibility, it reconstructs a dominant narrative representing non-heterosexuals as threatening the future survival of the nation, as imposing the sex-radical norms of a minority onto the majority, or as connected to a