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Concept learning and nonmonotonic reasoning

Humans learn new concepts extremely fast. One or two examples of a new concept are often sufficient for us to grasp its meaning. Traditional theories of concept formation, such as symbolic or connectionist representations, have problems explaining the quick learning exhibited by humans. In contrast to these representations, I advocate a third form of representing categories, which employs geometri

Prolargin and matrix metalloproteinase-2 in heart failure after heart transplantation and their association with haemodynamics

AIMS: Remodelling of the extracellular matrix (ECM) is a key mechanism involved in the development and progression of heart failure (HF) but also functional in associated pulmonary hypertension (PH). Our aim was to identify plasma ECM proteins associated to end-stage HF and secondary PH in relation to haemodynamics, before and after heart transplantation (HT).METHODS AND RESULTS: Twenty ECM plasma

Pervaporation-based hybrid processes for waste water treatment: Does it have a future?

Pervaporation offers solutions for a wide range of applications ranging from the dehydration of organic compounds to the recovery of organic compounds from water and the separation of organic mixtures. While the combination of pervaporation and distillation in a hybrid process to break azeotropes is well established on an industrial scale, successful applications of hydrophobic pervaporation are r

Where is the 'global' in the European Union's Health Research and Innovation Agenda?

Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries (LMICs) in EU health research has declined substantially. The Horizon Europe Research and Innovation Framework adopted by the European Parliament in April 2019 for the period 2021-20

The Tyranny of the Tenths. The Rise and Gradual Fall of Forward Guidance in Sweden 2007-2018

This paper examines the Swedish experience of forward guidance 2007-2018. We focus on three interrelated issues: first, the effects of forward guidance on the discussion within the Board of Directors of the Riksbank, second, on the communication between the Riksbank and the public, and third, on the interest rate expectations held by various groups in Swedish society. We conclude that forward guid

The institutionalisation of commercialism in the audit profession : How auditors constitute the commercial self in a large Chinese audit firm

Purpose: Previous literature on the commercialisation of the audit profession has focused on the coercive force of macro-institutional structures. The purpose of this paper is to focus on the agency of individual auditors and examine their active construction of the commercial self in a Big Four audit firm in China. Design/methodology/approach: This paper applied a qualitative research approach to

Direct Electron-Transfer Anisotropy of a Site-Specifically Immobilized Cellobiose Dehydrogenase

To study the direct electron transfer (DET) of the multicofactor enzyme cellobiose dehydrogenase (CDH) in regard to its orientation on an electrode surface, a recently published, maleimide-based immobilization method was used in combination with site-directed mutagenesis to establish different orientations on an electrode surface. CDH from Myriococcum thermophilum was chosen for this study because

Why Low Levels of Democracy Promote Corruption and High Levels Diminish It

Theory predicts democracy should reduce corruption. Yet, scholars have found that while corruption is low at high levels of democracy, it is high at modest levels, as well as low when democracy is absent. A weakness of studies that aim to explain this inverted curvilinear relationship is that they do not disaggregate the complex concepts of democracy and corruption. By contrast, this paper disaggr

Prevalence and correlates of physical violence and rape among female sex workers in Ethiopia : a cross-sectional study with respondent-driven sampling from 11 major towns

OBJECTIVE: This study examined the prevalence and correlates of physical violence and rape among female sex workers (FSWs) in Ethiopia.DESIGN: A cross-sectional study using respondent-driven sampling technique.SETTING: Eleven major towns in Ethiopia.PARTICIPANTS: 4900 FSWs.MAIN OUTCOME MEASURES: The prevalence of experiences of physical beating and rape.RESULTS: Among FSWs, 17.5% reported physical

Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk

A small number of circulating proteins have been reported to be associated with breast cancer risk, with inconsistent results. Herein, we attempted to identify novel protein biomarkers for breast cancer via the integration of genomics and proteomics data. In the Breast Cancer Association Consortium (BCAC), with 122,977 cases and 105,974 controls of European descendants, we evaluated the associatio

Evolution and future of total quality management : management control and organisational learning

The competitive position achieved by the Japanese and Western industries during the 1970s to mid-1990s, and 1980s to mid-1990s, respectively, derived from understanding, implementing, and developing Total Quality Management (TQM) as a comprehensive management philosophy. Several research and/or company studies provided evidence of this development and its impact on leading companies’ efficiency an

Fabrication of Tunnel FETs demonstrating sub-thermal subthreshold slope

Tunnel Field Effect Transistor (TFET), based on band-to-band tunneling, overcomes the thermal limit (subthreshold slope (S) > 60 mV/decade) of the MOSFETs by filtering the high-energy Fermi tail, thereby allowing a substantial reduction of supply voltage and power consumption. Despite the steep slope behavior, TFETs can suffer from ambipolarity wherein carriers tunnel into the channel at both high

Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator

Because of the limitations and liabilities of current testosterone therapies, non-steroidal tissue-selective androgen receptor modulators may provide a clinically meaningful advance in therapy. Using a functional cell-based assay AC-262536 was identified as a potent and selective AR ligand, with partial agonist activity relative to the natural androgen testosterone. A 2-week chronic study in castr

Distribution of 5‐hydroxytryptamine (serotonin) in the brain of the teleost Gasterosteus aculeatus L.

The distribution of serotoninergic neurons in the brain of the three‐spined stickleback was demonstrated with the indirect peroxidase‐antiperoxidase (PAP) immunohistochemical method with antibodies against serotonin. Serotoninergic perikarya were demonstrated in the brainstem reticular formation (nucleus raphe dorsalis, nucleus raphe medialis, and nucleus tegmenti dorsalis lateralis) and in the pe