Mapping of loci linked to degeneration of dopaminergic neurons in mice heterozygous for engrailed1
Abstract Engrailed1 (En1) is a developmental gene in the homeobox family, and it is well established as a key factor for programming and maintenance of dopaminergic neurons of the mesencephalon. Heterozygousity for the gene causes progressive degeneration of dopaminergic neurons of substantia nigra pars compacta and decreased striatal dopamine levels in most studied mouse strains, including Swiss