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Disability and Care in Late Medieval Lund, Sweden : An Analysis of Trauma and Intersecting Identities, Aided by Photogrammetric Digitization and Visualization

This article is a Bioarchaeology of Care and Disability focused analysis of an individual who suffered a severe fracture of the left knee in Late Medieval Lund, Scania (1300–1536 CE). We question the degree to which written sources from the period represent the reality of the disability experience, and to that end how identities intersect in the Medieval urban landscape. Following an index of care

Investigating SARS-CoV-2 Neutralising Antibody Response in Sheep

SARS-CoV-2 can cause clinical and inapparent disease and mortality in several animals cohabitating with humans, and sheep are susceptible to SARS-CoV-2 due to virus–receptor interactions similar to those in humans. Hence, sheep have the potential to be infected, spread, and develop neutralising antibodies (NAbs) against SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-Co

Islet NO-Synthases, extracellular NO and glucose-stimulated insulin secretion : Possible impact of neuronal NO-Synthase on the pentose phosphate pathway

The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied. Islets incubated at basal glucose showed modes

The CuB site in particulate methane monooxygenase may be used to produce hydrogen peroxide

Particulate methane monooxygenase (pMMO) is the most efficient of the two groups of enzymes that can hydroxylate methane. The enzyme is membrane bound and therefore hard to study experimentally. For that reason, there is still no consensus regarding the location and nature of the active site. We have used combined quantum mechanical and molecular mechanical (QM/MM) methods to study the reactivity

Global ocean surface heat fluxes derived from the maximum entropy production framework accounting for ocean heat storage and Bowen ratio adjustments

Ocean evaporation, represented by latent heat flux (LE), plays a crucial role in global precipitation patterns, water cycle dynamics, and energy exchange processes. However, existing bulk methods for quantifying ocean evaporation are associated with considerable uncertainties. The maximum entropy production (MEP) theory provides a novel framework for estimating surface heat fluxes, but its applica

The effect of soil physical structure in soil carbon and nitrogen distribution under different land use types in typical forest grassland transition zone on Loess Plateau, China

Land use/vegetation cover change, reflecting a range of human land use practices, is the most prevalent and immediate influence on alterations in soil quality. The physical structure of soil is crucial for safeguarding soil carbon (C) and nitrogen (N), as it modulates the physical protection mechanisms and the distribution of these elements within the soil. Nevertheless, the impact of soil physica

Respiratory support and bronchopulmonary dysplasia in infants born at 22–26 weeks gestation in Sweden, 2004–2007 and 2014–2016

Background Our aim was to evaluate if increased survival and new ventilation strategies were accompanied by a changed incidence of bronchopulmonary dysplasia (BPD) in Sweden over a decade. Methods Data from two Swedish population-based studies of live-born infants with gestational age (GA) 22–26 weeks, born during 2004–2007 (n=702) and 2014–2016 (n=885), were compared for survival, any BPD, modera

Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women—a case–control study

ObjectivesTo investigate bone mineral density (BMD), osteoporosis prevalence and SSc-specific associations of BMD in SSc patients compared with background population.MethodsIn total, 211 SSc patients (182 women, 29 men; mean age 61.3 and 62.2 years, respectively) and 505 age- and sex-matched controls from the same geographic area participated. BMD and T-score at total hip and lumbar spine was meas

Updated European Association of Urology Guidelines on the Use of Adjuvant Immune Checkpoint Inhibitors and Subsequent Therapy for Renal Cell Carcinoma

The KEYNOTE-564 trial showed that adjuvant immune checkpoint inhibitor (ICI) therapy with pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) and overall (OS) survival in localised clear-cell renal cell carcinoma (RCC) with a high risk of relapse. The TiNivo and CONTACT-03 trials have reported results for subsequent therapy after progression on ICI therapy in the met

Optimizing the quality of acoustophoretic separation by the in-flow mobility-ratio method

Achieving good acoustic particle or cell separation performance requires skilled operators, who must carefully fine-tune the input parameters (actuation voltages, flow rates, and flow split ratios). Often the fine-tuning is done by time-consuming parameter sweeps, which are tedious and expensive. Here, we present a straightforward model-based approach to determining input parameters that yield opt

Pathogenicity assessment of seven RYR1 variants in patients with confirmed susceptibility to malignant hyperthermia in the Netherlands

Background: Malignant hyperthermia (MH) susceptibility is associated with variants in RYR1, the gene encoding the skeletal muscle ryanodine receptor-1 (RyR1), in 70–75% of patients. Functional characterisation demonstrating an increased sensitivity to RyR1 agonists is necessary among other criteria for inclusion in the European Malignant Hyperthermia Group list of MH susceptibility diagnostic vari