Objective: To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis was restricted to participants in the age group 50-64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centre

Popular AbstractSveriges relativa välstånd kan vi till stor del tacka skogen för. Skogen har ända sedan industrialiseringen började ta fart i Sverige bidragit med betydande exportinkomster. För att bevara den inkomstkälla skogen utgör måste vi se till att det skogsbruk som bedrivs är uthålligt och tar hänsyn till såväl ekonomiska som biologiska och sociala aspekter. Skogsproduktionen ska med andraIt took 70-80 years to realize the width of the impact of industrialization on the forest ecosystems since a forest ecosystem is a "slow system" as seen from a human perspective. An anticipated future climate change and increasing carbon dioxide and ozone levels will change the conditions even more with time and the widely used statistical forest growth models will not be applicable anymore. Compu

Endogenous and exogenous sex hormones are of pivotal importance for women’s health. Hormone therapy has been widely studied but there is limited data about androgen and androgen replacement therapy. The aim of this study was to delineate the possible interrelations between endogenous androgens and women’s particularly pertaining to cardiovascular disease (CVD) and risk markers for CVD in perimeno

Allt sedan 1989 har vi i den södra sjukvårdsregionen gett en 20-poängskurs i grundläggande forskningsmetodik. Vår målsättning har varit att ge många läkare en basal vetenskaplig skolning till glädje för den vardagsnära kvalitetsutvecklingen och verksamhetsuppföljningen, men också att stimulera enstaka läkare till att påbörja en regelrätt forskarutbildning. Vi har genom åren presenterat utvecklingeAt the Department of Community Medicine at Lund University we have given courses in basic research methodology since 1989. The course has yielded 20 points of university credit, the equivalent of one full-time semester of studies, and it has been run part-time, covering one and a half years. Our aim has been to provide a large number of physicians with basic training in research methods, and to st

Control beliefs, i.e. a person's perceived control over his or her own behaviour, are important predictors of psychological functioning in old age. The aim of this study is to examine the mediating effect of housing-related control beliefs on the relationship between housing accessibility and independence in activities of daily living (ADL). Moreover, cross-national differences in five European co

Wind speed and direction have a significant effect on a flying bird's ground speed. Migrants are therefore expected to be sensitive to wind conditions and this should have consequences for optimal strategies of stopover and refuelling. Based on an earlier model of time-minimizing migration which includes wind condition, we investigate the consequences of the temporal correlation of wind conditions

Aim: Carbon monoxide (CO) in blood as assessed by the COHb% is a marker of the cardiovascular ( CV) risk in smokers. Non-smokers exposed to tobacco smoke similarly inhale and absorb CO. The objective in this population-based cohort study has been to describe inter-individual differences in COHb% in never smokers and to estimate the associated cardiovascular risk. Methods: Of the 8,333 men, aged 34

BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI). AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality. MATERIALS AND METHODS:

The European Pre-Standard for protective clothing against cold ENV 342:1998 suggests that the testing of thermal insulation should be made on a moving thermal manikin. In this way the value can be used to match requirements specified by the IREQ-method or as realistic input for prediction of thermal stress in other standards. It is known from prior work that insulation values measured with human s

A common methodology for analyzing metalworking fluid (MWF) aerosols in workplace air is based on gravimetry before and after organic solvent extraction of the MWFs from a suitable collection filter: Because MWFs have different chemical and physical properties, various mixtures of organic solvents have been used to extract the MWFs from their collection device. An alternative to organic solvents,

Background/Aims: Cocaine-and amphetamine-regulated transcript (CART) is an anorexigenic regulatory peptide highly expressed in the brain's appetite control centers, but also in peripheral neurons and in endocrine cells in the adrenal medulla, thyroid, pancreatic islets, and in the gastrointestinal tract. Plasma levels of CART were recently shown to be elevated in patients with neuroendocrine tumor

BACKGROUND AND AIMS: A pre-treatment determination of the thiopurine S-methyltransferase (TPMT) genotype or phenotype can identify patients at risk of developing severe adverse reactions from thiopurine treatment. The risk of misclassifying a patient might be dependent on the method used. The aim of this study was to investigate the concordance between TPMT genotyping and phenotyping. METHODS: T

The signaling mechanisms regulating neutrophil recruitment, systemic inflammation and T-cell dysfunction in polymicrobial sepsis are not clear. This study explored the potential involvement of the calcium/calcineurin-dependent transcription factor, nuclear factor of activated T-cells (NFAT) in abdominal sepsis. Cecal ligation and puncture (CLP) triggered NFAT-dependent transcriptional activity in

AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance t