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Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence

Science is a risky business, and risk-taking is a critical disposition for scientists. This study uses a combination of survey and bibliometric data to measure the degree of individual scientists' risk-taking and investigate its determinants. In particular, we focus on academic training as a critical arena for the socialization of risk-taking and examine whether and how risk-taking is transmitted

This study assesses the feasibility of extracting high-quality DNA from blood samples stored at – 20 °C for up to 21 years under suboptimal conditions. It addresses sample mishandling in research, where many samples lack proper biobank protocols. Prior studies focused on short-term storage and controlled conditions, highlighting the negative effects of freeze–thaw cycles. This study evaluates whet

In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

Introduction: Fatigue is a troublesome symptom after heart transplantation and is poorly studied in a long-term perspective. One hypothesis is that there is a strong relationship between fatigue, sleep problems, and self-efficacy, and that fatigue decreases self-efficacy. The aim of this study was to explore self-reported fatigue from the time on the waiting list to 5 years after heart transplanta

The major histocompatibility complex (MHC) plays a key role in pathogen recognition as part of the adaptive immune system. MHC I gene copy numbers in birds of the order Passeriformes (songbirds) are substantially larger compared to other birds. MHC I diversity and antigen presentation have been carefully characterised in chicken Gallus gallus of the order Galliformes; chickens express few MHC I ge

Kvantitativa riskanalyser (QRA) används för att bedöma säkerheten kring exempelvis kemiska anläggningar och transporter av farliga ämnen. I praktiken bygger många QRAs fortfarande på att man delar in världen i ett begränsat antal scenarier och gör flera beräkningar manuellt. Det gör metoden relativt grov och innebär att vissa antaganden och förenklingar blir svåra att upptäcka och diskutera. DennQuantitative Risk Analysis (QRA) for hazardous materials facilities remains dominated by event tree partitioning into discrete scenarios, with many calculations performed manually. This study formalizes the classical individual and societal risk metrics within the framework of probability theory. The resulting framework enables deeper theoretical inquiry and makes underlying assumptions explicit.

Climate change (CC) is altering the working conditions for water suppliers. To enhance preparedness, CC has been emphasised in the risk-based approach (RBA) and water safety planning guidelines. We studied how the RBA approach has been applied in small water supplies in the Nordic countries to mitigate CC related risks and impacts. We interviewed small water supply operators and authorities in eac

Vaccine hesitancy and anti-vaccination attitudes are becoming increasingly problematic in several Western countries where diseases that were nearly extinct are coming back. We here explore the role of perceived social support in understanding anti-vaccination attitudes. We argue that perceptions about having social support for one′s position may influence anti-vaccination attitudes among some soci

Background and aims: Problem gambling causes major social and psychiatric consequences, and there is need to develop feasible harm-reducing or therapeutic interventions. It has been suggested that gambling operators with responsible gambling intentions can intervene in order to identify and help reduce the harm in problem gamblers. However, user satisfaction, and the risk of negative reactions and

Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last

BackgroundThere is a need for the development of accurate, accessible and efficient screening instruments, focused on early-stage detection of neurocognitive disorders. The Geras Solutions cognitive test (GSCT) has showed potential as a digital screening tool for cognitive impairment but normative data are needed.ObjectiveThe aim of this study was to obtain normative data for the GSCT in cognitive

BACKGROUND: It is well known that electrical accidents can cause physical injury. Less well known is that long-term consequences may include emotional and cognitive problems. OBJECTIVE: To explore electricians' experiences and perceptions of work-related electrical accidents, with focus on psychological short- and long-term consequences, including how contacts with health care services and the wor

Developmental language disorder (DLD) is a common neurodevelopmental disorder with largely unknown etiology. Rare copy number variants (CNVs) have been implicated in the genetic architecture of other neurodevelopmental disorders (NDDs), which have led to clinical genetic testing recommendations for these disorders; however, the evidence is still lacking for DLD. We analyzed rare and de novo CNVs i

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in clas