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Din sökning på "swedish" gav 94314 sökträffar

Shared space : Motorists’ perspective

Background: Shared spaces are intended to constitute an attractive urban space for everyone by blending protected and unprotected road users. However, our previous study showed that pedestrians prefer the traditional division between protected and unprotected road users, at the same time as elderly pedestrians focused less on traffic when the division was recreated by large flowerpots. Objective:

Frequency and spectrum of mutations in human sperm measured using duplex sequencing correlate with trio-based de novo mutation analyses

De novo mutations (DNMs) are drivers of genetic disorders. However, the study of DNMs is hampered by technological limitations preventing accurate quantification of ultra-rare mutations. Duplex Sequencing (DS) theoretically has < 1 error/billion base-pairs (bp). To determine the DS utility to quantify and characterize DNMs, we analyzed DNA from blood and spermatozoa from six healthy, 18-year-old S

Pandrug-resistant Klebsiella pneumoniae isolated from Ukrainian war victims are hypervirulent

OBJECTIVES: Carbapenem- and colistin-resistant Klebsiella pneumoniae were isolated from war victims treated in hospitals in Ukraine. The question was whether these pandrug-resistant K. pneumoniae are pathogenic and capable of causing disease in a broader context.METHODS: Klebsiella pneumoniae clinical isolates (n = 37) were tested for antibiotic resistance and subjected to whole-genome sequencing

Concentrations of glutamate and N-acetylaspartate detected by magnetic resonance spectroscopy in the rat hippocampus correlate with hippocampal-dependent spatial memory performance

Magnetic resonance spectroscopy (MRS) has been employed to investigate brain metabolite concentrations in vivo, and they vary during neuronal activation, across brain activity states, or upon disease with neurological impact. Whether resting brain metabolites correlate with functioning in behavioral tasks remains to be demonstrated in any of the widely used rodent models. This study tested the hyp

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are

Gluten-free diet for pediatric patients with coeliac disease : A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease

Background and Objective: Coeliac disease is a chronic, immune-mediated disorder for which the only treatment consists of lifelong strict adherence to gluten-free diet (GFD). However, there is a lack of evidence-based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroent

Industry Practices for Challenging Autonomous Driving Systems with Critical Scenarios

Testing autonomous driving systems for safety and reliability is essential, yet complex. A primary challenge is identifying relevant test scenarios, especially the critical ones that may expose hazards or harm to autonomous vehicles and other road users. Although numerous approaches and tools for critical scenario identification are proposed, the industry practices for selection, implementation, a

Dwell-time station-service analysis using a Rasch analysis technique

In order to ensure punctual and robust service, it is vital to have a good understanding of the current performance of a railway network. Several approaches to doing so exist but lack the ability to compare both service and station performance in a single dimension. The study presented here proposes the use of the Rasch analysis technique within an operational context to compare the relative dwell

Associations between food intake and psychosomatic symptoms in 16-year-old adolescents

Aims: An increase in psychosomatic symptoms among adolescents has recently been reported. Few studies have examined the relation between food intake and psychosomatic symptoms. The aim was to study the association between food intake and overall psychosomatic burden and separate psychosomatic symptoms. Methods: In this cross-sectional study, we used data from 6248 girls and 7153 boys in south-east

Prediction of surface water turnover time in coastal waters using digital bathymetric information

This paper presents a new type of geographical information system (GIS) for scientific planning of coastal waters. One hypothesis in the work is that the morphometry of the coast plays a significant role for how the water system functions as a receiving water system, for example, as a receiver of industrial and urban pollution and in response to various forms of aquaculture. A digital technique fo

Public Agencies in International Cooperation under National Legal Frameworks : Legitimacy and Accountability in Internationalised Nordic Public Law

The last few decades have witnessed a fundamental change in the administrative law structures of many states. Through the phenomena labelled globalisation, internationalisation and Europeanisation, the national public bodies have seen partially new legal frameworks for administrative activities, judicial review of decisions and accountability regimes. This is very clear in regard to administrative

A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells

Endocrine disrupting chemicals (EDCs) are man-made compounds that alter functions of the endocrine system. Environmental mixtures of EDCs might have adverse effects on human health, even though their individual concentrations are below regulatory levels of concerns. However, studies identifying and experimentally testing adverse effects of real-life mixtures are scarce. In this study, we aimed at

Temporal Patterns of Glucagon and Its Relationships with Glucose and Insulin following Ingestion of Different Classes of Macronutrients

Background: glucagon secretion and inhibition should be mainly determined by glucose and insulin levels, but the relative relevance of each factor is not clarified, especially following ingestion of different macronutrients. We aimed to investigate the associations between plasma glucagon, glucose, and insulin after ingestion of single macronutrients or mixed-meal. Methods: thirty-six participants

Impact of age at onset on symptom profiles, treatment characteristics and health-related quality of life in Parkinson’s disease

Parkinson’s disease (PD) is typically considered an age-related disease, but the age at disease onset can vary by decades between patients. Aging and aging-associated diseases can affect the movement system independently of PD, and advanced age has previously been proposed to be associated with a more severe PD phenotype with accelerated progression. In this work, we investigated how interactions

Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study

Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization. Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy. Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five Europe

Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells

Purpose: Metformin (MF) intake associates with reduced levels of circulating low-density lipoprotein-cholesterol (LDL-C). This has been attributed to the activation of AMPK, which differentially regulates the expression of multiple genes involved in cholesterol synthesis and trafficking. However, the exact mechanism underlying the LDL-C lowering effect of MF remains ambiguous. Methods: MF-treated