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The brown bear population in Scandinavia has substantially increased the last 30 years, in-creasing the probability of interactions between humans and bears. This environmental change is evident to many who live in brown bear areas and to them it is important to feel safe when engaged in nature based activities. This research project aimed to, further develop and evaluate two specific intervention
Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic
The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. TNF-a is produced from the ear
In view of unsolved issues regarding cellular events underlying the adaptation of insulin secretion to insulin resistance, together with the observation that insulin secretion induced by the gastrointestinal hormone and neuropeptide cholecystokinin (CCK) is not solely explained by phospholipase C-protein kinase C (PLC-PKC) pathway activation, this study aimed at delineate mechanisms responsible fo
In the present thesis, the quantitative role of active transport (transcytosis) in bulk transvascular protein movement in vivo was evaluated. Using chemical transcytosis inhibition (N-ethylmaleimide (NEM) and filipin), we were able to show that NEM actually increases endothelial permeability to macromolecules, probably as a result of unspecific toxic action on endothelial cells. Filipin, on the ot
The procurement process can be defined as all the activities required in getting a product or a service from the supplier to a final destination. It encompasses the purchasing function, storing, transportation and manages the relations between suppliers and internal customers. It is a cyclical process involving the following activities: analysis, planning, implementation, and measurement. The perf
Popular Abstract in English What is common between the science of physics and global politics? They both define power in terms of energy. Indeed, the uneven distribution of petroleum reserves has been one of the main reasons of social, political and economic problems worldwide. Even more worrying is the rapid increase in the levels of greenhouse gases in the atmosphere. This is mainly caused by ouCaldicellulosiruptor saccharolyticus is an extremely thermophilic, strictly anaerobic, Gram-positive and cellulolytic microorganism with a natural ability to produce hydrogen (H2) at nearly theoretical maximum yield, i.e. 4 mol/ mol of glucose. Due to its CO2-free combustion and high energy density, among other desirable properties, H2is touted as a fuel of the future. Biological H2 production b
This report presents the findings from a pre-study concerning the opportunities and challenges of digitalization and automation in bridge design. The project approach is divided into three parts: 1) a short review of the relevant literature, 2) investigations concerning bridge industry perspectives (with focus on bridge consultants), and 3) the identification of future research needs based on part
The background to this thesis is the fact that high temperature during transport and storage, degrade the glucose of peritoneal dialysis fluid (PD-fluid), into a toxic substance. Research at Gambro has shown that exposure to high temperatures can destroy the PD-fluid in just a few hours, requiring months to repair. With this knowledge it became important to monitor the temperature, and evaluate wh
IntroductionConsidering that on average in developed countries we spend about 65% of our time in private homes, understanding the exposures in homes is of outmost importance. Aerosol concentrations indoors come from indoor sources, infiltrate from outdoors and can be formed from precursors both of indoor and outdoor origin. Several characteristics and processes influence the properties of aerosols
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“Pamoja” Solidarity and Human Rights Exhibition Day: 30 October 2023 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Ana
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