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Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. The gold standard medication is

Women's Human Rights and Islam : a Study of Three Attempts at Accommodation

The dissertation focuses on interpretations of Islam that claim compatibility with international human rights norms in the context of women’s rights. These interpretations are seen as parts of an on-going contemporary international debate on women’s human rights and Islam that engages Muslims as well as non-Muslims. Existing UN-formulated international human rights schemes are a basic starting poi

Bending the Kuznets Curve - Wrenching and Levelling Forces during Agricultural Transformation in Taiwan and Chile

What are the effects of growth on equality in a long-term perspective? What are the effects of different patterns of equality on subsequent growth? And why are these questions relevant for the understanding of economic development? These are the overriding questions posed in the dissertation. They are addressed in the context of long-term change from economic backwardness to modern economic growth

Geometric Models of Similarity

This dissertation examines and discusses some phenomena related to the geometric representation of similarity. It takes its inspiration from the existing body of empirical research within the fields of perceptual and cognitive psychology, but also connects to certain areas of machine learning. The problems discussed concern the modelling of information integration behavior when concepts like asym

On the role of mast cells in chemokine-induced leukocyte recruitment

Leukocyte recruitment is considered to playa key role in numerous inflammatory diseases. Tissue accumulation of Jeukocytes is a multi-steps process comprising rolling, adhesion and transmigration. This process depends on the function of several different cells, including leukocytes, endothelial cells, mast cells and macrophages as well as a wide spectrum of inflammatory mediators, such as TNF-alph

Product-service systems: Panacea or myth?

Life cycle environmental problems have been addressed by a number of strategies. However, the results are mostly lamentable because solutions are searched for within the same paradigms that give rise to the problems. This research questions the vision of linear material growth and searches for ways to sustain economic growth without putting the natural environment under stress. The research explor

Childhood sexual abuse. Women's Mental and Social Health Before and After Group Therapy

The aim of the study was to evaluate changes in psychological and social variables before and after group therapy for adult women who were sexually abused in childhood. Other aims were to describe and evaluate the traumafocused group therapy by consumer satisfaction, to describe the women's health before group therapy start and to evaluate the impact of single childhood sexual abuse variables on m

Extensible Compiler Construction

Processing of programs is a core area in computer science. A compiler that translates source text to machine language is the most well-known kind of tool in this area, but there are numerous other kinds of related applications: source-to-source translators, refactoring tools, reengineering tools, metrics tools, consistency checkers, etc. These tools perform similar analyses and can therefore benef

Different Images of Science - A study of how science is constituted in exhibitions

Within the science and technology centre (STC) movement there exists explicit aims and ambitions to enhance visitors’ interest in and knowledge about science. Meanwhile, several researches question the choice of the scientific content in exhibitions when arguing that a too unproblematic view of science commonly is presented. But what images and aspects of science are visitors actually confronted w

Physical Aspects of Thermotherapy - A study of heat transport with a view to treatment optimisation

Local treatment with the aim to destruct tissue by heating (thermotherapy) may in some cases be an alternative or complement to surgical methods, and has gained increased interest during the last decade. The major advantage of these, often minimally-invasive methods, is that the disease can be controlled with reduced treatment trauma and complications. The extent of thermal damage is a complex fun

Setting the Marketing Scene: Reality Production in Everyday Marketing Work

The aim of this thesis is to offer a contribution to the understanding of marketing work. In orthodox, mainstream marketing management literature, the work of marketing is commonly depicted as a fairly straightforward practice, technical in character, neutral in terms of social values and ideologies, operating within an objective and pre-given world. A counter picture to this idealised view of mar

Mannen i ledet. Takt och otakt i värnpliktens skugga

This dissertation deals with young men who in the mid 1990s made their military service at a cannon company at Wende’s artillery regiment in the scanian town Hässleholm. ”Cannon” refers not only to cannons, but also to haubitses, grenade-throwers and other heavy arms. The focus, however, is on cultural and social aspects of everyday military service. What does actually happen in the encounter betw

Surface Studies of Model Systems relevant for Pd and Ag Catalysts

This PhD thesis reports on investigations of the atomic scale structure of model catalysts relevant for the catalytic oxidation of CO and methane over Pd, and NOx reduction over silver-alumina, important reactions in automotive catalysts. By using complementary experimental techniques such as X-ray Photoelectron Spectroscopy, High Pressure X-ray Photoelectron Spectroscopy, Surface X-ray Diffractio

Bilden, texten och kyrkorummet. En studie av scener kring Jesu födelse och Kristoffermotivet i Sydskandinaviens medeltida kalkmåleri

The subject of the thesis is the narratives in medieval mural paintings in southern Scandinavia c 1100-1530. Its aim is to examine their relationship to texts, to the viewer and to the church space, where the viewer looks at the murals. Two different subjects have been chosen for study: S Christopher and the Nativity of Christ. From the corpus of preserved mural paintings with these subjects in so

BMP treatment for improving tendon repair. Studies on rat and rabbit Achilles tendons

We wanted to improve tendon healing by adding a growth factor. Bone Morphogenetic Proteins (BMPs) are well known to stimulate bone healing and bone formation. The local environment is of major importance for cell differentiation after a BMP has been added. Cartilage Derived Morphogenetic Proteins (CDMPs) -1, -2 and -3 (BMP 14, 13 and 12 or GDF 5, 6 and 7) form a subgroup in the BMP-family and are

John Cowper Powys: Displacements of Voice and Genre

This study is based on dialogic readings of two of John Cowper Powys´s major novels, A Glastonbury Romance and Porius. The aim of this thesis is to demonstrate the interrelationship in the examined texts between the chain of narrative displacements and the frequent changes of voice and genre. Powys´s cornucopian writing with its wide employment of characteristics from various genres makes it parti

Decision Making in Groups : Group membership effects on post-decision processes

The present thesis examines differences in post-decision processes between members of groups and individual decision makers. The empirical studies employed a decision theoretical framework based on Differentiation and Consolidation (Diff Con) Theory. Diff Con theory proposes that decision makers strive to achieve sufficient differentiation in their evaluation of one alternative versus competing al

Net-Charge Fluctuations in Ultra-Relativistic Nucleus-Nucleus Collisions

PHENIX is one of four experiments at the Relativistic Heavy-Ion Collider, RHIC. The high-energy heavy-ion collisions provided by this accelerator offer the possibility to study nuclear matter at high temperature and density. The high multiplicity of particles produced in these collisions puts high demands on detector performance. Providing space points along particle trajectories, the Pad Chamber

T cells, Cytokines, and Genetic Factors in Autoimmunity Studies of experimental models of arthritis and sialadenitis

To understand the pathogenesis of autoimmune diseases we have to consider the problem from different angles. Animal models provide a tool to further understand these complex diseases, as the influence of genetic and environmental factors could be limited. Moreover, modern transgenic techniques have made it possible to study the role of certain genes and gene products in the development of diseases

BIOACTIVE ORGANOMETALLIC COMPOUNDS

Various metal complexes have been used in medicine traditionally, although their use was often connected with mystery and with a lack of empirically (clinically) proven effect. In modern times, the development of biochemistry, bioinorganic and bioorganometallic chemistry allows us more in-depth understanding of biological action of metal containing substances. Among metal-containing drugs used tod